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  • 达玛-20(22),24-二烯-3β,6α,12β-三醇

    Quasipanaxatriol

    达玛-20(22),24-二烯-3β,6α,12β-三醇
    产品编号 CFN95248
    CAS编号 171903-78-9
    分子式 = 分子量 C30H50O3 = 458.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    达玛-20(22),24-二烯-3β,6α,12β-三醇 CFN95248 171903-78-9 1mg QQ客服:2159513211
    达玛-20(22),24-二烯-3β,6α,12β-三醇 CFN95248 171903-78-9 5mg QQ客服:2159513211
    达玛-20(22),24-二烯-3β,6α,12β-三醇 CFN95248 171903-78-9 10mg QQ客服:2159513211
    达玛-20(22),24-二烯-3β,6α,12β-三醇 CFN95248 171903-78-9 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Biotech R&D Institute (USA)
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  • Universidad Veracuzana (Mexico)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tropical Journal of Pharmaceutical Research 2021, 20(6):1165-1170.
  • Mediators Inflamm. 2016, 2016:6189590
  • Mol Cells.2018, 41(8):771-780
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • Journal of Molecular Liquids2021, 334:116014.
  • Food Chem.2021, 377:131976.
  • The Catharanthus Genome2022,35-83.
  • Current Pharmaceutical Analysis2017, 13(5)
  • Int J Mol Sci.2021, 22(16):8604.
  • International J of Green Pharmacy2019, 13(3)
  • Srinagarind Medical Journal2019, 34(1)
  • Biomolecules.2020, 10(2):E184
  • Molecules.2021, 26(4):817.
  • Institut Pasteur Korea2020, doi: 10.21203.
  • Aquaculture2017, 481:94-102
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Curr Issues Mol Biol.2023, ;45(2):1601-1612.
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • Biomolecules.2020, 10(6):925.
  • LWT2020, 110397
  • Int J Mol Sci.2021, 22(14):7324.
  • ...
  • 生物活性
    Description: Quasipanaxatriol can greatly enhance the cytotoxicity of the anti-cancer drugs in P388/ADM cells.
    In vitro:
    Planta Med 1995; 61(5): 409-413.
    Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistant P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids.[Reference: WebLink]

    METHODS AND RESULTS:
    Examined in vitro were the effects of some triterpenoids from Panax (Araliaceae) and Glycyrrhiza (Leguminosae) spp. on the sensitivity to daunomycin (DAU) and vinblastine (VBL) of adriamycin (ADM)-resistant P388 leukemia cells (P388/ADM), which were resistant to multiple anticancer drugs. Quasipanaxatriol, 20(S)-protopanaxatriol, ginsenoside Rh2, and compound K greatly enhanced the cytotoxicity of the anti-cancer drugs in P388/ADM cells. The extent of enhancement was different among the triterpene compounds; the 4- to 46-fold increase in DAU cytotoxicity was observed in P388/ADM cells in the presence of non-toxic or marginally toxic concentrations of individual compounds, while those for VBL were in the ratios of 2- to 37-fold. The maximum increase in cytotoxicity was observed with 50 µM quasipanaxatriol; the resistance indices defined to be the ratios of the IC50 values for P388/ADM and P388 parental cells decreased from 79 to 1.7 and from 180 to 4.9 in the cases of DAU and VBL, respectively.
    CONCLUSIONS:
    The reversal of DAU resistance in P388/ADM by quasipanaxatriol could be explained by the effective accumulation of the drugs mediated by the DAU-efflux blockage.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1801 mL 10.9004 mL 21.8007 mL 43.6015 mL 54.5019 mL
    5 mM 0.436 mL 2.1801 mL 4.3601 mL 8.7203 mL 10.9004 mL
    10 mM 0.218 mL 1.09 mL 2.1801 mL 4.3601 mL 5.4502 mL
    50 mM 0.0436 mL 0.218 mL 0.436 mL 0.872 mL 1.09 mL
    100 mM 0.0218 mL 0.109 mL 0.218 mL 0.436 mL 0.545 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参皂苷Rb2; Ginsenoside Rb2 CFN99965 11021-13-9 C53H90O22 = 1079.27 20mg QQ客服:1457312923
    人参皂苷Rb3; Ginsenoside Rb3 CFN99966 68406-26-8 C53H90O22 = 1079.27 20mg QQ客服:1457312923
    三七皂苷Fc; Notoginsenoside Fc CFN93283 88122-52-5 C58H98O26 = 1211.4 20mg QQ客服:2159513211
    人参皂苷Rb1; Ginsenoside Rb1 CFN99964 41753-43-9 C54H92O23 = 1109.29 20mg QQ客服:2159513211
    三七皂苷Fa; Notoginsenoside Fa CFN93284 88100-04-3 C59H100O27 = 1241.4 20mg QQ客服:1413575084
    三七皂苷R4; Notoginsenoside R4 CFN91142 87741-77-3 C59H100O27 = 1241.4 5mg QQ客服:1413575084
    人参皂苷Ra2; Ginsenoside Ra2 CFN93293 83459-42-1 C58H98O26 = 1211.39 5mg QQ客服:1457312923
    三七皂苷Fe; Notoginsenoside Fe CFN93282 88105-29-7 C47H80O17 = 917.12 20mg QQ客服:215959384
    人参皂苷Rc; Ginsenoside Rc CFN99973 11021-14-0 C53H90O22 = 1079.27 20mg QQ客服:2159513211
    人参皂苷F1; Ginsenoside F1 CFN99754 53963-43-2 C36H62O9 = 638.88 20mg QQ客服:2159513211

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