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  • 原藜芦碱

    Protoveratrine A

    原藜芦碱
    产品编号 CFN98521
    CAS编号 143-57-7
    分子式 = 分子量 C41H63NO14 = 793.94
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Veratrum nigrum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    原藜芦碱 CFN98521 143-57-7 1mg QQ客服:215959384
    原藜芦碱 CFN98521 143-57-7 5mg QQ客服:215959384
    原藜芦碱 CFN98521 143-57-7 10mg QQ客服:215959384
    原藜芦碱 CFN98521 143-57-7 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • Food Sci Nutr.2023, 00:1-10.
  • J Chromatogr Sci.2020, 58(6):485-493.
  • Biorxiv.2020, doi: 10.1101.
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  • Evid Based Complement Alternat Med.2018, 2018:1073509
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  • Research on Crops.2017, 18(2)
  • Nutrients.2020, 12(3):595.
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  • ...
  • 生物活性
    Description: Protoveratrine A has anti-hypertensive action, it has some effects on cardiovascular and respiratory systems in rats in reducing the blood pressure and heart rate,prolonging the QTc interval,decreasing the respiratory rate and increasing the respiratory width. Protoveratrine A can increase K + uptake from frog skeletal muscle and cause this tissue to release more calcium (Ca ++ ). Protoveratrine A seems to involve at least in part an inhibition of dopaminergic neuron activity, it enhances the release of acetylcholine from the nerve terminals during the resting period and at low frequency of stimulation.
    Targets: Calcium Channel | Potassium Channel
    In vitro:
    J. Pharm. Pharmacol. 1959, 11(S1):176-84.
    THE EFFECT OF PROTOVERATRINE A ON POTASSIUM AND CALCIUM ION MOVEMENTS IN MUSCLE AND NERVE.[Reference: WebLink]
    The effects of Protoveratrine A on the efflux of potassium ions (K+) from frog and rat skeletal muscle and the isolated electrically driven rat heart have been studied.
    METHODS AND RESULTS:
    No effect was seen upon the rate of efflux from skeletal muscle but that from the heart was increased. Protoveratrine A increases K+ uptake from frog skeletal muscle and causes this tissue to release more calcium (Ca++). There was no increase in Ca++ release from lobster nerve treated with Protoveratrine A. The theoretical implications of these findings are discussed.
    In vivo:
    Toxicon. 1983;21(4):503-14.
    Potentiation by crotamine of the depolarizing effects of batrachotoxin, protoveratrine A and grayanotoxin I on the rat diaphragm.[Pubmed: 6312634]
    The interactions between crotamine and tetrodotoxin and group II sodium channel toxins, including batrachotoxin, protoveratrine A and grayanotoxin I, were studied on the rat diaphragm muscle.
    METHODS AND RESULTS:
    When the diaphragm was pretreated with 0.1 micrograms crotamine/ml for 45 min (a condition known to depolarize the muscle by less than 3 mV, which is only 20% of the maximal depolarization induced by a saturating concentration of crotamine), the rate of depolarization by group II toxins was markedly enhanced and the time to reach the steady state depolarization was greatly shortened. The maximal depolarizations induced by each of the group II toxins, however, were not increased. Pretreatment with saturating concentrations of crotamine also caused no change of the steady state depolarization induced by batrachotoxin or grayanotoxin I. Moreover, pretreatment of the diaphragm with a high concentration of grayanotoxin I, whose effect is reversible, did not impede the depolarizing effect of crotamine. Tetrodotoxin restored the membrane potential, depolarized by crotamine, with 50% restoration at a concentration of 16 ng/ml, no matter whether a high (20 micrograms/ml) or a low (2 micrograms/ml) concentration of crotamine were used.
    CONCLUSIONS:
    The above results indicate that there is no competition between crotamine and group II toxins or between crotamine and tetrodotoxin. However, crotamine may affect the binding of group II toxins allosterically, increasing their affinity although the intrinsic activity may not be changed.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2595 mL 6.2977 mL 12.5954 mL 25.1908 mL 31.4885 mL
    5 mM 0.2519 mL 1.2595 mL 2.5191 mL 5.0382 mL 6.2977 mL
    10 mM 0.126 mL 0.6298 mL 1.2595 mL 2.5191 mL 3.1489 mL
    50 mM 0.0252 mL 0.126 mL 0.2519 mL 0.5038 mL 0.6298 mL
    100 mM 0.0126 mL 0.063 mL 0.126 mL 0.2519 mL 0.3149 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    梭砂贝母碱; Hupehenine CFN90475 98243-57-3 C27H45NO2 = 415.65 20mg QQ客服:3257982914
    西贝碱; Sipeimine CFN99711 61825-98-7 C27H43NO3 = 429.64 20mg QQ客服:2159513211
    西贝母碱苷; Edpetiline CFN90883 32685-93-1 C33H53NO8 = 591.8 20mg QQ客服:2056216494
    贝母素甲; Peimine CFN99996 23496-41-5 C27H45NO3 = 431.66 20mg QQ客服:2159513211
    贝母素乙; Peiminine CFN99997 18059-10-4 C27H43NO3 = 429.64 20mg QQ客服:3257982914
    原藜芦碱; Protoveratrine A CFN98521 143-57-7 C41H63NO14 = 793.94 5mg QQ客服:215959384
    乙酸阿比特龙酯; Abiraterone Acetate CFN90022 154229-18-2 C26H33NO2 = 391.55 5mg QQ客服:2056216494

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