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  • 茯苓新酸A

    Poricoic acid A(F)

    茯苓新酸A
    产品编号 CFN92838
    CAS编号 137551-38-3
    分子式 = 分子量 C31H46O5 = 498.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Wolfiporia cocos (Schw.) Ryv.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    茯苓新酸A CFN92838 137551-38-3 10mg QQ客服:215959384
    茯苓新酸A CFN92838 137551-38-3 20mg QQ客服:215959384
    茯苓新酸A CFN92838 137551-38-3 50mg QQ客服:215959384
    茯苓新酸A CFN92838 137551-38-3 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Helmholtz Zentrum München (Germany)
  • University of Padjajaran (Indonesia)
  • University of Vienna (Austria)
  • MTT Agrifood Research Finland (Finland)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Monash University Malaysia (Malaysia)
  • Kyushu University (Japan)
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  • Lodz University of Technology (Poland)
  • Georgia Institute of Technology (USA)
  • Medical University of South Carolina (USA)
  • Tohoku University (Japan)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Res Int.2021, 148:110607.
  • Int J Mol Sci.2017, 18(12)
  • Molecules.2021, 26(2):313.
  • Phytomedicine2022, 104:154318
  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • BMB Rep.2018, 51(5):249-254
  • Food Research International2020, 108987
  • Biomolecules.2021, 11(10):1537.
  • Integr Cancer Ther.2018, 17(3):832-843
  • ACS Chem Biol.2019, 14(5):873-881
  • Int. J. Mol. Sci.2022, 23(14),7699;
  • Mol Cells.2015, 38(9):765-72
  • Molecules.2019, 24(10):E1926
  • J.of Traditional&Complementary Med.2022, 10.1016:j.jtcme.
  • Biomedicines.2021, 9(8):996.
  • Antioxidants (Basel).2021, 10(10):1620.
  • Phytomedicine.2021, 93:153796.
  • Pharmaceutics.2021, 13(2):187.
  • Food Chem.2019, 276:768-775
  • Pak J Pharm Sci.2019, 32(6)
  • Asian J Beauty Cosmetol2022, 20(2):183-191
  • Metabolites.2023, 13(5):625.
  • J Appl Toxicol.2020, 40(7):965-978.
  • ...
  • 生物活性
    Description: Poricoic acid A(F) shows anti-inflammatory activity. It is a potential whitening active ingredient, it exhibits good inhibitory effects on the activities of monophenolase and diphenolase in mushroom tyrosinase, as well as a certain inhibitory effect on tyrosinase in B16 cells.
    Targets: Immunology & Inflammation related | Tyrosinase
    In vitro:
    Zhongcaoyao, 2017(9):328.
    Tyrosinase Inhibitory Activity of Total Triterpenes and Poricoic Acid A Isolated from Poria cocos.[Reference: WebLink]
    With the improvement of people's living standards, people's requests for beauty are increasing. Skin whitening and lightening have become the pursuit of many women, and whitening and removing freckles have become the focus of scientific research. At present, widely used whitening agents, such as kojic acid, vitamin C, and its derivatives, have shortcomings such as poor stability and retarded effect. Therefore, safer and more effective whitening products from herbs are urgently needed. To explore the possibility of triterpenes as whitening active substance, the effects of total triterpenes of Poria (TTP) and poricoic acid A(F) (PAA) on mushroom tyrosinase activities and B16 cells were investigated, and their mechanisms on mushroom tyrosinase were also studied.
    METHODS AND RESULTS:
    Using arbutin and nicotinamide as reference substances, we determinated the inhibitory effects of TTP and PAA on mushroom tyrosinase and tyrosinase in B16 cells and then studied the inhibitory mechanism on mushroom tyrosinase. TTP and PAA exhibited good inhibitory effects on the activities of monophenolase and diphenolase in mushroom tyrosinase, as well as a certain inhibitory effect on tyrosinase in B16 cells.
    CONCLUSIONS:
    TTP and PAA are potential whitening active ingredients.
    Journal of Natural Products, 2011, 74(2):137-144.
    Cytotoxic and Apoptosis-Inducing Activities of Triterpene Acids from Poria cocos.[Reference: WebLink]

    METHODS AND RESULTS:
    Six lanostane-type triterpene acids (1a-6a), isolated from Poria cocos , and their methyl ester (1b-6b) and hydroxy derivatives (1c-6c) were prepared. Upon evaluation of the cytotoxic activity of these compounds against leukemia (HL60), lung (A549), melanoma (CRL1579), ovary (NIH:OVCAR-3), breast (SK-BR-3), prostate (DU145), stomach (AZ521), and pancreas (PANC-1) cancer cell lines, 11 compounds (5a, 6a, 2b-5b, 1c, and 3c-6c) exhibited activity with single-digit micromolar IC(50) values against one or more cell lines. Poricotriol A (1c), a hydroxy derivative of poricoic acid A(F) (1a), exhibited potent cytotoxicities against six cell lines with IC(50) values of 1.2-5.5 μM. poricotriol Ainduced typical apoptotic cell death in HL60 and A549 cells on evaluation of the apoptosis-inducing activity by flow cytometric analysis. Western blot analysis in HL60 cells showed that poricotriol A activated caspases-3, -8, and -9, while increasing the ratio of Bax/Bcl-2.
    CONCLUSIONS:
    This suggested that poricotriol A induced apoptosis via both mitochondrial and death receptor pathways in HL60. On the other hand, poricotriol A did not activate caspases-3, -8, and -9, but induced translocation of apoptosis-inducing factor (AIF) from mitochondria and increased the ratio of Bax/Bcl-2 in A549. This suggested that poricotriol A induced apoptosis via the mitochondrial pathway mostly by translocation of AIF, independent from the caspase pathway in A549. Furthermore, poricotriol A was shown to possess high selective toxicity in lung cancer cells since it exhibited only weak cytotoxicity against a normal lung cell line (WI-38).
    In vivo:
    Free Radic Biol Med . 2019 Apr;134:484-497.
    Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis[Pubmed: 30716432]
    Abstract Renal ischemia-reperfusion injury (IRI) is a complex syndrome, which causes chronic kidney disease (CKD) after recovery from IRI-mediated acute kidney injury (AKI). There is no single therapy that could effectively prevent the renal injury after ischemia. In this study, the effects of melatonin or poricoic acid A (PAA) and their combination were investigated in protecting against AKI-to-CKD transition in rats and hypoxia/reoxygenation (H/R)-induced injury in cultured renal NRK-52E cells. Melatonin and PAA significantly reduced the magnitude of rise in serum creatinine and urea levels in IRI rats at days 3 and 14. Our results further showed that treatment with melatonin and PAA ameliorated renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation via regulation of nuclear factor-kappa B (NF-κB) and nuclear factor-erythroid-2-related factor 2 (Nrf2) pathways in IRI rats. Melatonin and PAA protected against AKI-to-CKD transition by regulating growth arrest-specific 6 (Gas6)/AxlNFκB/Nrf2 signaling cascade. Melatonin and PAA initiallyupregulated Gas6/Axl signaling to reduce oxidative stress and inflammation in AKI and subsequently downregulated Gas6/Axl signaling to attenuate renal fibrosis and progression to CKD. Melatonin and PAA inhibited expression of extracellular matrix proteins. Poricoic acid A enhances melatonin-mediated inhibition of AKI-to-CKD transition by the regulating Gas6/AxlNFκB/Nrf2 signaling cascade. Notably, our study first identified Axl as a promising therapeutic target for prevention of AKI-to-CKD transition. Keywords: Acute kidney injury; Chronic kidney disease; Gas6/Axl; Inflammation and oxidative stress; Melatonin; Poria cocos; Poricoic acid A.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0052 mL 10.0261 mL 20.0521 mL 40.1043 mL 50.1303 mL
    5 mM 0.401 mL 2.0052 mL 4.0104 mL 8.0209 mL 10.0261 mL
    10 mM 0.2005 mL 1.0026 mL 2.0052 mL 4.0104 mL 5.013 mL
    50 mM 0.0401 mL 0.2005 mL 0.401 mL 0.8021 mL 1.0026 mL
    100 mM 0.0201 mL 0.1003 mL 0.2005 mL 0.401 mL 0.5013 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    茯苓酸; 茯灵酸; Pachymic acid CFN99590 29070-92-6 C33H52O5 = 528.76 20mg QQ客服:2159513211
    二氢齿孔酸; Dehydroeburicoic acid CFN92740 6879-05-6 C31H48O3 = 468.7 5mg QQ客服:3257982914
    去氢土莫酸; Dehydrotumulosic acid CFN92837 6754-16-1 C31H48O4 = 484.7 10mg QQ客服:2056216494
    去氢茯苓酸; Dehydropachymic acid CFN92742 77012-31-8 C33H50O5 = 526.8 10mg QQ客服:2056216494
    3-表去氢土莫酸; 3-Epidehydrotumulosic acid CFN92743 167775-54-4 C31H48O4 = 484.7 5mg QQ客服:215959384
    3-表去氢茯苓酸; 3-Epidehydropachymic acid CFN92738 168293-15-0 C33H50O5 = 526.8 5mg QQ客服:215959384
    6alpha-羟基去氢茯苓酸; 6alpha-Hydroxydehydropachymic acid CFN95412 176390-67-3 C33H50O6 = 542.8 5mg QQ客服:1413575084
    过氧去氢土莫酸; Peroxydehydrotumulosic acid CFN92836 943225-53-4 C31H46O6 = 514.7 5mg QQ客服:2159513211
    多孔菌酸C; Polyporenic acid C CFN92739 465-18-9 C31H46O4 = 482.7 10mg QQ客服:215959384
    16-O-Acetylpolyporenic acid C; 16-O-Acetylpolyporenic acid C CFN96159 2535-06-0 C33H48O5 = 524.7 5mg QQ客服:1413575084

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