苦玄参苷IA
Picfeltarraenin IA
|
|
产品编号 |
CFN99942 |
| CAS编号 |
97230-47-2 |
| 分子式 = 分子量 |
C41H62O13 = 762.92 |
| 产品纯度 |
>=98% |
| 物理属性 |
White powder |
| 化合物类型 |
Triterpenoids |
| 植物来源 |
The herbs of Picria felterrae Lour. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 苦玄参苷IA |
CFN99942 |
97230-47-2 |
10mg |
QQ客服：215959384 |
| 苦玄参苷IA |
CFN99942 |
97230-47-2 |
20mg |
QQ客服：215959384 |
| 苦玄参苷IA |
CFN99942 |
97230-47-2 |
50mg |
QQ客服：215959384 |
| 苦玄参苷IA |
CFN99942 |
97230-47-2 |
100mg |
QQ客服：215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
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Centralised Purchases Unit (CPU), B.I.T.S (India)
University of Otago (New Zealand)
Universidade Federal de Pernambuco (UFPE) (Brazil)
Pennsylvania State University (USA)
University of Pretoria (South Africa)
VIT University (India)
Georgia Institute of Technology (USA)
Mendel University in Brno (Czech Republic)
Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
University of Oslo (Norway)
University of Wuerzburg (Germany)
Sapienza University of Rome (Italy)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Picfeltarraenin IA has anti-inflammatory activity, it is a strong AChE inhibitior, and an potential PI3K and epidermal growth factor receptor (EGFR ) inhibitor. It acts as an inhibitor on both the classical and alternative pathways of the complement system. |
| Targets: |
IL Receptor | PGE | NF-kB | COX | p65 | EGFR | PI3K | Akt |
| In vitro: |
| Oncol Lett. 2016 Feb;11(2):1195-1200. | | Picfeltarraenin IA inhibits lipopolysaccharide-induced inflammatory cytokine production by the nuclear factor-κB pathway in human pulmonary epithelial A549 cells.[Pubmed: 26893718 ] | The present study aimed to investigate the effect of Picfeltarraenin IA (IA) on respiratory inflammation by analyzing its effect on interleukin (IL)-8 and prostaglandin E2 (PGE2) production. The expression of cyclooxygenase 2 (COX2) in human pulmonary adenocarcinoma epithelial A549 cells in culture was also examined.
METHODS AND RESULTS:
Human pulmonary epithelial A549 cells and the human monocytic leukemia THP-1 cell line were used in the current study. Cell viability was measured using a methylthiazol tetrazolium assay. The production of IL-8 and PGE2 was investigated using an enzyme-linked immunosorbent assay. The expression of COX2 and nuclear factor-κB (NF-κB)-p65 was examined using western blot analysis. Treatment with lipopolysaccharide (LPS; 10 μg/ml) resulted in the increased production of IL-8 and PGE2, and the increased expression of COX2 in the A549 cells. Furthermore, IA (0.1-10 μmol/l) significantly inhibited PGE2 production and COX2 expression in cells with LPS-induced IL-8, in a concentration-dependent manner. The results suggested that IA downregulates LPS-induced COX2 expression, and inhibits IL-8 and PGE2 production in pulmonary epithelial cells. Additionally, IA was observed to suppress the expression of COX2 in THP-1 cells, and also to regulate the expression of COX2 via the NF-κB pathway in the A549 cells, but not in the THP-1 cells.
CONCLUSIONS:
These results indicate that IA regulates LPS-induced cytokine release in A549 cells via the NF-κB pathway. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.3108 mL |
6.5538 mL |
13.1075 mL |
26.2151 mL |
32.7688 mL |
| 5 mM |
0.2622 mL |
1.3108 mL |
2.6215 mL |
5.243 mL |
6.5538 mL |
| 10 mM |
0.1311 mL |
0.6554 mL |
1.3108 mL |
2.6215 mL |
3.2769 mL |
| 50 mM |
0.0262 mL |
0.1311 mL |
0.2622 mL |
0.5243 mL |
0.6554 mL |
| 100 mM |
0.0131 mL |
0.0655 mL |
0.1311 mL |
0.2622 mL |
0.3277 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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