苦玄参苷IA

Picfeltarraenin IA

	产品编号	CFN99942
	CAS编号	97230-47-2
	分子式 = 分子量	C₄₁H₆₂O₁₃ = 762.92
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Picria felterrae Lour.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
苦玄参苷IA	CFN99942	97230-47-2	10mg	QQ客服：215959384
苦玄参苷IA	CFN99942	97230-47-2	20mg	QQ客服：215959384
苦玄参苷IA	CFN99942	97230-47-2	50mg	QQ客服：215959384
苦玄参苷IA	CFN99942	97230-47-2	100mg	QQ客服：215959384

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Melbourne University (Australia)

Uniwersytet Gdański (Poland)

Universiti Sains Malaysia (Malaysia)

National Hellenic Research Foundation (Greece)

National Cancer Institute (USA)

University of Wollongong (Australia)

Seoul National University of Science and Technology (Korea)

Universidade Federal de Pernambuco (UFPE) (Brazil)

Harvard University (USA)

Universidad de Ciencias y Artes de Chiapas (Mexico)

Leibniz Institute of Plant Biochemistry (Germany)

Siksha O Anusandhan University (India)

Utah State University (USA)

University of Maryland School of Medicine (USA)

More...

Description:

Picfeltarraenin IA has anti-inflammatory activity, it is a strong AChE inhibitior, and an potential PI3K and epidermal growth factor receptor (EGFR ) inhibitor. It acts as an inhibitor on both the classical and alternative pathways of the complement system.

Targets:

IL Receptor | PGE | NF-kB | COX | p65 | EGFR | PI3K | Akt

In vitro:

Oncol Lett. 2016 Feb;11(2):1195-1200.

Picfeltarraenin IA inhibits lipopolysaccharide-induced inflammatory cytokine production by the nuclear factor-κB pathway in human pulmonary epithelial A549 cells.[Pubmed: 26893718 ]

The present study aimed to investigate the effect of Picfeltarraenin IA (IA) on respiratory inflammation by analyzing its effect on interleukin (IL)-8 and prostaglandin E2 (PGE2) production. The expression of cyclooxygenase 2 (COX2) in human pulmonary adenocarcinoma epithelial A549 cells in culture was also examined.
METHODS AND RESULTS:
Human pulmonary epithelial A549 cells and the human monocytic leukemia THP-1 cell line were used in the current study. Cell viability was measured using a methylthiazol tetrazolium assay. The production of IL-8 and PGE2 was investigated using an enzyme-linked immunosorbent assay. The expression of COX2 and nuclear factor-κB (NF-κB)-p65 was examined using western blot analysis. Treatment with lipopolysaccharide (LPS; 10 μg/ml) resulted in the increased production of IL-8 and PGE2, and the increased expression of COX2 in the A549 cells. Furthermore, IA (0.1-10 μmol/l) significantly inhibited PGE2 production and COX2 expression in cells with LPS-induced IL-8, in a concentration-dependent manner. The results suggested that IA downregulates LPS-induced COX2 expression, and inhibits IL-8 and PGE2 production in pulmonary epithelial cells. Additionally, IA was observed to suppress the expression of COX2 in THP-1 cells, and also to regulate the expression of COX2 via the NF-κB pathway in the A549 cells, but not in the THP-1 cells.
CONCLUSIONS:
These results indicate that IA regulates LPS-induced cytokine release in A549 cells via the NF-κB pathway.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
泽泻醇O; Alisol O	CFN92404	928148-51-0	C₃₂H₄₈O₅ = 512.7	5mg	QQ客服：1457312923
16-氧代泽泻醇A; 16-Oxoalisol A	CFN92547	124515-98-6	C₃₀H₄₈O₆ = 504.7	5mg	QQ客服：2159513211
泽泻醇C; Alisol C	CFN92545	30489-27-1	C₃₀H₄₆O₅ = 486.7	5mg	QQ客服：2159513211
泽泻醇 C-23-醋酸酯; Alisol C monoacetate	CFN90199	26575-93-9	C₃₂H₄₈O₆ = 528.73	20mg	QQ客服：1413575084
泽泻醇 K 23-醋酸酯; Alisol K 23-acetate	CFN92405	228095-18-9	C₃₂H₄₆O₆ = 526.7	5mg	QQ客服：3257982914
新化合物48; New compound 48	CFN95943	N/A	C₄₁H₆₄O₁₃ = 765.0	5mg	QQ客服：1457312923
苦玄参苷IA; Picfeltarraenin IA	CFN99942	97230-47-2	C₄₁H₆₂O₁₃ = 762.92	20mg	QQ客服：1413575084
新化合物49; New compound 49	CFN95944	N/A	C₄₂H₆₆O₁₄ = 795.0	5mg	QQ客服：215959384
苦玄参苷IB; Picfeltarraenin IB	CFN90712	97230-46-1	C₄₂H₆₄O₁₄ = 792.95	20mg	QQ客服：2159513211
苦玄参苷IV; Picfeltarraenin IV	CFN90719	184288-35-5	C₄₇H₇₂O₁₈ = 925.06	5mg	QQ客服：2159513211

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3108 mL	6.5538 mL	13.1075 mL	26.2151 mL	32.7688 mL
5 mM	0.2622 mL	1.3108 mL	2.6215 mL	5.243 mL	6.5538 mL
10 mM	0.1311 mL	0.6554 mL	1.3108 mL	2.6215 mL	3.2769 mL
50 mM	0.0262 mL	0.1311 mL	0.2622 mL	0.5243 mL	0.6554 mL
100 mM	0.0131 mL	0.0655 mL	0.1311 mL	0.2622 mL	0.3277 mL