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  • 氧化芍药苷

    • 氧化芍药苷

    Oxypaeoniflorin

    氧化芍药苷
    		产品编号 CFN99589
    CAS编号 39011-91-1
    分子式 = 分子量 C23H28O12 = 496.46
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Monoterpenoids
    植物来源 The roots of Paeonia lactiflora Pall.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    氧化芍药苷 CFN99589 39011-91-1 10mg QQ客服：3257982914
    氧化芍药苷 CFN99589 39011-91-1 20mg QQ客服：3257982914
    氧化芍药苷 CFN99589 39011-91-1 50mg QQ客服：3257982914
    氧化芍药苷 CFN99589 39011-91-1 100mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2023, 24(18):14077.
  • Int J Mol Sci.2015, 16(8):18396-411
  • J Adv Res.2019, 17:85-94
  • Sci Rep.2018, 8(1):12970
  • Front Immunol.2017, 8:1542
  • Preprints2024, 2085.v1
  • Food Funct.2022, D1FO03838A.
  • FEBS J.2022, 10.1111:febs.16676.
  • Int J Mol Sci.2024, 25(22):12152.
  • UDC.2020, 19(4).
  • Oncotarget.2016, 8(51):88386-88400
  • Tea Res. Ins. Of China2017, 1-12
  • Advances in Traditional Medicine2020, 10.1007
  • ACS Chem Biol.2019, 14(5):873-881
  • Eur J Pharmacol.2024, 978:176800.
  • Molecules.2019, 24(2):329
  • J Hematol Oncol.2018, 11(1):112
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Int Immunopharmacol.2023, 123:110572.
  • J Ethnopharmacol.2020, 269:113752.
  • Phytomedicine.2019, 65:153089
  • Elife.2021, 10:e68058.
  • Crystals2020, 10(3), 206.
  • ...
    • 生物活性
    Description: Oxypaeoniflorin in rat plasma and was successfully applied to pharmacokinetic study.
    In vitro:
    Acta Biochim Pol . 2020 Jun 18;67(2):239-245.
    Oxypaeoniflorin improves myocardial ischemia/reperfusion injury by activating the Sirt1/Foxo1 signaling pathway[Pubmed: 32550708]
    Abstract Myocardial ischemia/reperfusion (MI/R) injury is a leading cause of damage to cardiac tissues and is associated with high mortality and disability rates worldwide. Oxypaeoniflorin (OPA) has been found to be the main constituent of Paeonia veitchii Lynch. This study was conducted to explore the effect of OPA on MI/R injury and its potential mechanism. An in vivo MI/R injury model was established by transient coronary ligation in BALB/c mice, and an in vitro hypoxia/reoxygenation (H/R) injury model was established with rat cardiomyocyte H9c2 cells. Echocardiographic assessments demonstrated that OPA significantly reduced disruption of cardiac function and improved the indicators of ejection fraction (EF) and fractional shortening (FS). The enzyme-linked immunosorbent assay (ELISA) results suggested that OPA significantly reduced the release of myocardial infarction-related factors, such as the creatine kinase (CK-MB), cardiac troponin I (cTnI) and cardiac troponin T (cTnT). Additionally, hematoxylin-eosin (HandE) staining demonstrated that OPA markedly inhibited the myocardial apoptosis and necrosis caused by MI/R. Consistently, the results obtained from the cell counting kit-8 (CCK-8) and flow cytometry assays revealed that OPA obviously reversed the H/R-induced decrease in cell activity and increase in apoptosis of H9c2 cells. Furthermore, western blot assays indicated that OPA inhibited apoptosis by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling pathway in myocardial tissues and H9c2 cells. Collectively, these novel findings are the first to provide strong evidence that OPA attenuates MI/R injury by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling-mediated anti-apoptotic pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0143 mL 10.0713 mL 20.1426 mL 40.2852 mL 50.3565 mL
    5 mM 0.4029 mL 2.0143 mL 4.0285 mL 8.057 mL 10.0713 mL
    10 mM 0.2014 mL 1.0071 mL 2.0143 mL 4.0285 mL 5.0357 mL
    50 mM 0.0403 mL 0.2014 mL 0.4029 mL 0.8057 mL 1.0071 mL
    100 mM 0.0201 mL 0.1007 mL 0.2014 mL 0.4029 mL 0.5036 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    苯甲酰氧化芍药苷; Benzoyloxypeoniflorin CFN90662 72896-40-3 C30H32O13 = 600.57 20mg QQ客服：3257982914
    牡丹皮苷C; Mudanpioside C CFN90661 172760-03-1 C30H32O13 = 600.57 20mg QQ客服：2056216494
    没食子酰芍药苷; Galloylpaeoniflorin CFN90831 122965-41-7 C30H32O15 = 632.6 10mg QQ客服：1457312923
    芍药苷元酮; Paeoniflorigenone CFN96022 80454-42-8 C17H18O6 = 318.3 5mg QQ客服：3257982914
    芍药内苷B; Paeonilactone B CFN96055 98751-78-1 C10H12O4 = 196.2 5mg QQ客服：3257982914
    芍药内苷C; Paeonilactone C CFN96056 98751-77-0 C17H18O6 = 318.3 5mg QQ客服：1413575084
    芍药内苷A; Paeonilactone A CFN96059 98751-79-2 C10H14O4 = 198.2 5mg QQ客服：3257982914
    苯甲酰芍药内酯苷; Benzoylalbiflorin CFN91579 184103-78-4 C30H32O12 = 584.6 10mg QQ客服：2056216494
    芍药苷; Paeoniflorin CFN99544 23180-57-6 C23H28O11 = 480.45 20mg QQ客服：1457312923
    氧化芍药苷; Oxypaeoniflorin CFN99589 39011-91-1 C23H28O12 = 496.46 20mg QQ客服：1457312923

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