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  • 千层纸素A-7-0-β-D-葡萄糖醛酸苷

    Oroxylin A 7-O-beta-D-glucuronide

    千层纸素A-7-0-β-D-葡萄糖醛酸苷
    产品编号 CFN90191
    CAS编号 36948-76-2
    分子式 = 分子量 C22H20O11 = 460.39
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria regeliana Nakai
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    千层纸素A-7-0-β-D-葡萄糖醛酸苷 CFN90191 36948-76-2 10mg QQ客服:1457312923
    千层纸素A-7-0-β-D-葡萄糖醛酸苷 CFN90191 36948-76-2 20mg QQ客服:1457312923
    千层纸素A-7-0-β-D-葡萄糖醛酸苷 CFN90191 36948-76-2 50mg QQ客服:1457312923
    千层纸素A-7-0-β-D-葡萄糖醛酸苷 CFN90191 36948-76-2 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Sanford Burnham Medical Research Institute (USA)
  • Lodz University of Technology (Poland)
  • Sri Ramachandra University (India)
  • Utrecht University (Netherlands)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biomedicines.2022, 10(2):463.
  • Anal Chim Acta.2018, 1039:162-171
  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • Nutrients.2019, 11(6):E1380
  • Korean J. Food Preserv. 2021, 28(6):846-856.
  • Indian J Pharm Sci.2022, 84(3):144-151
  • Chemistry of Plant Materials.2016, 33-46
  • Cell Signal.2022, 99:110433.
  • PLoS One.2018, 13(11):e0208055
  • Clin Transl Oncol.2019, 10.1007
  • Molecules.2023, 28(8):3414.
  • Bio-protocol2018, 9(14):e3301
  • Cell Rep.2022, 39(1):110643.
  • Key Engineering Materials2022, 931(47-53).
  • Int J Mol Sci.2022, 23(20):12516.
  • Chem Biol Interact.2019, 298:1-7
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • BMC Complement Med Ther. 2020, 20(1):91.
  • Front Pharmacol.2019, 10:1025
  • J Agric Food Chem.2017, 65(13):2670-2676
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
  • Food Chem.2020, 327:126992.
  • Int J Oncol.2016, 49(4):1497-504
  • ...
  • 生物活性
    Description: Oroxylin A-7-O-glucuronide and wogonoside should also be served as the chemical markers together with baicalin for the quality control of herbs and proprietary traditional Chinese medicine (PTCM) products of radix Scutellariae.. Oroxylin A 7-O-glucuronide can inhibit total prolyl oligopeptidase (POP) activity.
    Targets: IL Receptor | Prolyl oligopeptidase
    In vitro:
    Beijing Da Xue Xue Bao. 2009 Oct 18;41(5):578-84.
    Flavonoids from Scutellaria baicalensis and their bioactivities.[Pubmed: 19829679]
    To study the flavonoids of Scutellaria baicalensis and their bioactivities.
    METHODS AND RESULTS:
    Chromatographic methods were used to separate compounds, spectral methods were used to determine the structures and bioactivities of the flavonoids were screened in several models in vitro. Nine compounds were isolated and identified as baicalein (1), wogonin (2), oroxylin A (3), 5, 7, 2', 6'-tetrahydroxyflavone (4), viscidulin III (5), baicalin (6), wogonoside (7), Oroxylin A 7-O-beta-D-glucuronide (8) and chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside (9).
    CONCLUSIONS:
    Baicalein had good anti-bacteria activity, and some compounds showed inhibiting activity against IL-1beta converting enzyme. The 13C NMR data of compounds 9 were assigned correctly by 2D nuclear magnetic resonance (NMR).
    Fitoterapia. 2010 Sep;81(6):552-6.
    Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers.[Pubmed: 20117183 ]
    Prolyl oligopeptidase (POP) is a serine protease highly expressed in the brain that hydrolyses peptide bonds at the carboxyl terminal of prolyl residues. There is evidence that this enzyme participates in several functions of the central nervous system. Scutellaria racemosa Pers demonstrated significant and selective POP inhibition.
    METHODS AND RESULTS:
    Fractionation of the hydroalcoholic extract resulted in the isolation of four main constituents identified for the first time from S. racemosa Pers, the triterpenoid lupeol (1) and the flavonoids oroxylin A (5,7-dihydroxy-6-methoxyflavone, 2), hispidulin (4',5,7-trihydroxy-6-methoxyflavone, 3), and oroxyloside (Oroxylin A 7-O-beta-D-glucuronide, 4). Inhibitory assays indicated that 3 and 4 at a concentration of 100 microM inhibit 43 and 34% of total POP activity, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1721 mL 10.8604 mL 21.7207 mL 43.4414 mL 54.3018 mL
    5 mM 0.4344 mL 2.1721 mL 4.3441 mL 8.6883 mL 10.8604 mL
    10 mM 0.2172 mL 1.086 mL 2.1721 mL 4.3441 mL 5.4302 mL
    50 mM 0.0434 mL 0.2172 mL 0.4344 mL 0.8688 mL 1.086 mL
    100 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.4344 mL 0.543 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    汉黄芩苷; Wogonoside CFN99710 51059-44-0 C22H20O11 = 460.39 20mg QQ客服:3257982914
    穿心莲黄酮苷C; Andrographidine C CFN97852 113963-39-6 C23H24O10 = 460.44 5mg QQ客服:2056216494
    5-Hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside; 5-Hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside CFN95209 942626-74-6 C23H26O10 = 462.5 10mg QQ客服:1457312923
    穿心莲黄酮苷A; Andrographidine A CFN95210 113963-37-4 C23H26O10 = 462.5 10mg QQ客服:215959384
    白杨素-7-O-龙胆二糖苷; Chrysin 7-O-beta-gentiobioside CFN90833 88640-89-5 C27H30O14 = 578.5 5mg QQ客服:2056216494
    木蝴蝶苷A; Oroxin A CFN99712 57396-78-8 C21H20O10 = 432.38 20mg QQ客服:1457312923
    黄芩苷; Baicalin CFN99111 21967-41-9 C21H18O11 = 446.37 20mg QQ客服:1413575084
    黄芩苷甲酯; Baicalin methyl ester CFN92283 82475-03-4 C22H20O11 = 460.4 20mg QQ客服:1413575084
    黄芩素 7-O-beta-D-葡萄糖醛酸乙酯; Baicalein 7-O-beta-D-ethylglucuronide CFN91993 675624-38-1 C23H22O11 = 474.41 5mg QQ客服:2056216494
    黄芩素 6-O-葡萄糖苷; Baicalein 6-O-glucoside CFN92361 28279-72-3 C21H20O10 = 432.4 5mg QQ客服:2056216494

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