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  • 麦冬皂苷D'

    Ophiopogonin D'

    麦冬皂苷D'
    产品编号 CFN90503
    CAS编号 65604-80-0
    分子式 = 分子量 C44H70O16 = 855.02
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Ophiopogon japonicus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    麦冬皂苷D' CFN90503 65604-80-0 1mg QQ客服:3257982914
    麦冬皂苷D' CFN90503 65604-80-0 5mg QQ客服:3257982914
    麦冬皂苷D' CFN90503 65604-80-0 10mg QQ客服:3257982914
    麦冬皂苷D' CFN90503 65604-80-0 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Johannes Gutenberg University Mainz (JGU) (Germany)
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  • University of Parma (Italy)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Pharmaceutics.2021, 13(7):1028.
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Appl. Sci. 2021, 11(22),10569
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  • Forensic Sci Int.2022, 341:111475.
  • Semyung University2017, 149407
  • BMC Plant Biol.2018, 18(1):122
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Int J Mol Sci.2019, 20(8):E1855
  • J of Apicultural Research2020, 10.1080
  • Plos One.2020, 10.1371
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Molecules.2019, 24(22):E4022
  • Lab Chip.2018, 18(6):971-978
  • Molecules. 2013, 18(11):14105-21
  • Molecules.2021, 26(13):4081.
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • Korean Journal of Pharmacognosy2014, 113-120
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Cells.2022, 11(6):931.
  • Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.
  • ...
  • 生物活性
    Description: Ophiopogonin D' can activate SIRT1, it also noncompetitively inhibits UGT1A6 and UGT1A10.
    Targets: SIRT1 | UGT1A6 | UGT1A10
    In vitro:
    Evid Based Complement Alternat Med. 2014;2014:594354.
    The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase.[Pubmed: 25530784]
    The mechanism of shengmai injection- (SMI-) related drug-drug interaction remains unclear. Evaluation of the inhibition potential of SMI's ingredients towards UDP-glucuronosyltransferases (UGTs) activity will provide a new insight to understand SMI-related drug-drug interaction.
    METHODS AND RESULTS:
    In vitro incubation system to model UGT reaction was used. Recombinant UGT isoforms-catalyzed 4-methylumbelliferone (4-MU) glucuronidation and UGT1A4-catalyzed trifluoperazine (TFP) glucuronidation reactions were employed to phenotype the inhibition profile of maidong's components towards the activity of UGT isoforms. Different inhibition potential of maidong's components towards various UGT isoforms was observed. Based on the inhibition kinetic investigation results, ophiopogonin D (OD) noncompetitively inhibited UGT1A6 and competitively inhibited UGT1A8, ophiopogonin D' (OD') noncompetitively inhibited UGT1A6 and UGT1A10, and ruscorectal (RU) exhibited competitive inhibition towards UGT1A4. The inhibition kinetic parameters were calculated to be 20.6, 40.1, 5.3, 9.0, and 0.02 μM, respectively.
    CONCLUSIONS:
    In combination with our previous results obtained for the inhibition of UGT isoforms by ginsenosides and wuweizi components, the important SMI ingredients exhibiting strong inhibition towards UGT isoforms were highlighted. All the results obtained in the present study provide a new insight to understand SMI-related drug-drug interaction.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1696 mL 5.8478 mL 11.6956 mL 23.3913 mL 29.2391 mL
    5 mM 0.2339 mL 1.1696 mL 2.3391 mL 4.6783 mL 5.8478 mL
    10 mM 0.117 mL 0.5848 mL 1.1696 mL 2.3391 mL 2.9239 mL
    50 mM 0.0234 mL 0.117 mL 0.2339 mL 0.4678 mL 0.5848 mL
    100 mM 0.0117 mL 0.0585 mL 0.117 mL 0.2339 mL 0.2924 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    短葶山麦冬皂苷C; Liriope muscari baily saponins C CFN90194 87480-46-4 C44H70O14 = 855.02 20mg QQ客服:2159513211
    麦冬皂苷D'; Ophiopogonin D' CFN90503 65604-80-0 C44H70O16 = 855.02 10mg QQ客服:2056216494
    纤细薯蓣皂苷; Gracillin CFN98537 19083-00-2 C45H72O17 = 885.04 20mg QQ客服:215959384
    重楼皂苷D; Polyphyllin D CFN90255 50773-41-6 C44H70O16 = 855.02 20mg QQ客服:2159513211
    薯蓣皂甙;薯蓣皂苷; Dioscin CFN99516 19057-60-4 C45H72O16 = 869.05 20mg QQ客服:2159513211
    重楼皂苷II; Polyphyllin II CFN99953 76296-72-5 C44H70O16 = 855.02 5mg QQ客服:3257982914
    重楼皂苷E; Polyphyllin E CFN90446 76296-73-6 C51H82O20 = 1015.18 5mg QQ客服:2056216494
    重楼皂苷F; Polyphyllin F CFN90447 76296-74-7 C51H82O20 = 1015.18 5mg QQ客服:3257982914

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