Info: Read More
  • 中药标准品生产商,产品定制服务
  • 橄榄苦苷

    Oleuropein

    橄榄苦苷
    产品编号 CFN98416
    CAS编号 32619-42-4
    分子式 = 分子量 C25H32O13 = 540.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The herbs of Olea europaea L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    橄榄苦苷 CFN98416 32619-42-4 10mg QQ客服:215959384
    橄榄苦苷 CFN98416 32619-42-4 20mg QQ客服:215959384
    橄榄苦苷 CFN98416 32619-42-4 50mg QQ客服:215959384
    橄榄苦苷 CFN98416 32619-42-4 100mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Indonesia (Indonesia)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Sanford Burnham Medical Research Institute (USA)
  • University of Bordeaux (France)
  • Univerzita Karlova v Praze (Czech Republic)
  • Sri Ramachandra University (India)
  • Nanjing University of Chinese Medicine (China)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Lund University (Sweden)
  • Lodz University of Technology (Poland)
  • Subang Jaya Medical Centre (Malaysia)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Beira Interior (Portugal)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Life (Basel).2022, 12(10):1630.
  • Sci Rep.2018, 8(1)
  • Appl. Sci. 2021, 11(22), 10552
  • J Ethnopharmacol.2017, 198:91-97
  • Sci Rep.2019, 9:19059
  • Scientific World Journal.2014, 2014:654193
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • J Ethnopharmacol.2017, 206:73-77
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • J Appl Biol Chem2022, 65:343−348.
  • Molecules.2017, 22(11)
  • Pharmacognosy Magazine2018, 14(56):418-424
  • BMB Rep.2018, 51(5):249-254
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Eur Endod J.2020, 5(1):23-27.
  • J Biol Chem.2014, 289(3):1723-31
  • Wageningen University & Research2018, January 2018
  • Appl. Sci.2020, 10(23), 8729
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Biorxiv2019, 10.1101
  • Phytochemistry2018, 15:83-92
  • ...
  • 生物活性
    Description: Oleuropein exhibits anti-ischemic, antioxidative, hypolipidemic, in vitro antimycoplasmal , anti-inflammatory, and anti-cancer effects., it also may be helpful in the prevention of diabetic complications associated with oxidative stress. Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion, and reduces viremia in duck hepatitis B virus (DHBV)-infected ducks. Oleuropein reduces TLR and MAPK signaling.
    Targets: ROS | DNA/RNA Synthesis | HBV | TLR | MAPK | Bcl-2/Bax | PI3K | Akt | COX | NOS | NO | IL Receptor | p65 | AP-1 | ERK | JNK
    In vitro:
    Mol Med Rep. 2015 Jun;11(6):4617-24.
    Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line.[Pubmed: 25634350]
    Oleuropein is a polyphenol, that is found in extra‑virgin olive oil. Previous studies have shown that oleuropein inhibits cell proliferation and induces apoptosis in breast cancer, colorectal cancer and thyroid cancer. The aim of the present study was to investigate the effects of oleuropein in hepatocellular carcinoma (HCC) cells.
    METHODS AND RESULTS:
    The results of Cell Counting Kit 8 and flow cytometric analysis indicated that oleuropein effectively inhibited cell viability and induced apoptosis in HepG2 human hepatoma cells in a dose‑dependent manner, through activation of the caspase pathway. Proapoptotic Bcl‑2 family members, BAX and Bcl‑2, were involved in oleuropein‑induced apoptosis. The phosphatidylinositol 3‑kinase/protein kinase B (PI3K/AKT) signaling pathway was also shown to be involved in this process. Oleuropein was demonstrated to suppress the expression of activated AKT. In addition, AKT overexpression promoted cell survival following treatment with oleuropein, while inhibition of AKT promoted cell death. Furthermore, the data demonstrated that oleuropein induces the production of reactive oxygen species (ROS) and that the function of oleuropein is, at least partially, ROS‑dependent.
    CONCLUSIONS:
    These results suggest that oleuropein may be a promising novel chemotherapeutic agent in hepatocellular carcinoma.
    Int J Antimicrob Agents. 2002 Oct;20(4):293-6.
    In vitro antimycoplasmal activity of oleuropein.[Pubmed: 12385687]

    METHODS AND RESULTS:
    The activity of oleuropein, a phenolic glycoside contained in olive oil, was investigated in vitro against Mycoplasma hominis, Mycoplasma fermentans, Mycoplasma pneumoniae and Mycoplasma pirum. Oleuropein inhibited mycoplasmas at concentrations from 20 to 320 mg/l.
    CONCLUSIONS:
    The MICs of oleuropein to M. pneumoniae, M. pirum, M. hominis and M. fermentans were 160, 320, 20 and 20 mg/l, respectively.
    Int J Mol Sci . 2018 Feb 28;19(3):686.
    Potential Health Benefits of Olive Oil and Plant Polyphenols[Pubmed: 29495598]
    Abstract Beneficial effects of natural plant polyphenols on the human body have been evaluated in a number of scientific research projects. Bioactive polyphenols are natural compounds of various chemical structures. Their sources are mostly fruits, vegetables, nuts and seeds, roots, bark, leaves of different plants, herbs, whole grain products, processed foods (dark chocolate), as well as tea, coffee, and red wine. Polyphenols are believed to reduce morbidity and/or slow down the development of cardiovascular and neurodegenerative diseases as well as cancer. Biological activity of polyphenols is strongly related to their antioxidant properties. They tend to reduce the pool of reactive oxygen species as well as to neutralize potentially carcinogenic metabolites. A broad spectrum of health-promoting properties of plant polyphenols comprises antioxidant, anti-inflammatory, anti-allergic, anti-atherogenic, anti-thrombotic, and anti-mutagenic effects. Scientific studies present the ability of polyphenols to modulate the human immune system by affecting the proliferation of white blood cells, and also the production of cytokines or other factors that participate in the immunological defense. The aim of the review is to focus on polyphenols of olive oil in context of their biological activities. Keywords: Olea europea; anticancer therapy; hydroxytyrosol; oleuropein; olive oil; polyphenols.
    In vivo:
    J Nutr Biochem. 2004 Aug;15(8):461-6.
    Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion.[Pubmed: 15302080 ]
    The potential protective effects of oleuropein, a dietary antioxidant of olive oil, has been investigated in the isolated rat heart.
    METHODS AND RESULTS:
    The organs were subjected to 30 minutes of no-flow global ischemia and then reperfused. At different time intervals, the coronary effluent was collected and assayed for creatine kinase activity as well as for reduced and oxidized glutathione. In addition, the extent of lipid peroxidation was evaluated by measuring thiobarbituric acid reactive substance concentration in cardiac muscle. Pretreatment with 20 microg/g oleuropein before ischemia resulted in a significant decrease in creatine kinase and reduced glutathione release in the perfusate. The protective effect of oleuropein against the post-ischemic oxidative burst was investigated by measuring the release, in the coronary effluent, of oxidized glutathione, a sensitive marker of heart's exposure to oxidative stress. Reflow in ischemic hearts was accompanied by a prompt release of oxidized glutathione; in ischemic hearts pretreated with oleuropein, this release was significantly reduced. Membrane lipid peroxidation was also prevented by oleuropein. The reported data provide the first experimental evidence of a direct cardioprotective effect of oleuropein in the acute events that follow coronary occlusion, likely because of its antioxidant properties.
    CONCLUSIONS:
    This finding strengthens the hypothesis that the nutritional benefit of olive oil in the prevention of coronary heart disease can be also related to the high content of oleuropein and its derivatives. Moreover, our data, together with the well documented antithrombotic and antiatherogenic activity of olive oil polyphenols, indicate these antioxidants as possible therapeutic tools for the pharmacological treatment of coronary heart disease as well as in the case of cardiac surgery, including transplantation.
    J Ethnopharmacol. 2009 Sep 7;125(2):265-8.
    Antiviral efficacy against hepatitis B virus replication of oleuropein isolated from Jasminum officinale L. var. grandiflorum.[Pubmed: 19580857 ]
    Jasminum officinale L. var. grandiflorum (JOG) is a folk medicine used for the treatment of hepatitis in south of China. Phytochemical studies showed that secoiridoid glycosides are the typical constituents of this plant. The present study was undertaken to evaluate the effect of oleuropein (Ole) derived from the flowers of JOG on hepatitis B virus (HBV) replication in HepG2 2.2.15 cell line in vitro and duck hepatitis B virus (DHBV) replication in ducklings in vivo.
    METHODS AND RESULTS:
    The extracellular hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) concentrations in cell culture medium were determined by ELISA. DHBV in duck serum was analyzed by dot blot. Ole blocks effectively HBsAg secretion in HepG2 2.2.15 cells in a dose-dependent manner (IC(50)=23.2 microg/ml). Ole (80 mg/kg, intraperitoneally, twice daily) also reduced viremia in DHBV-infected ducks.
    CONCLUSIONS:
    Ole therefore warrants further investigation as a potential therapeutic agent for HBV infection.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8501 mL 9.2507 mL 18.5014 mL 37.0028 mL 46.2535 mL
    5 mM 0.37 mL 1.8501 mL 3.7003 mL 7.4006 mL 9.2507 mL
    10 mM 0.185 mL 0.9251 mL 1.8501 mL 3.7003 mL 4.6253 mL
    50 mM 0.037 mL 0.185 mL 0.37 mL 0.7401 mL 0.9251 mL
    100 mM 0.0185 mL 0.0925 mL 0.185 mL 0.37 mL 0.4625 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Nudifloside B ; Nudifloside B CFN89186 297740-98-8 C43H60O22 = 928.92 5mg QQ客服:215959384
    Jasminin; Jasminin CFN89180 30164-93-3 C26H38O12 = 542.57 5mg QQ客服:1413575084
    迎春花甙; Jasmoside CFN89269 97763-17-2 C43H60O22 = 928.92 5mg QQ客服:215959384
    Isojasminin; Isojasminin CFN89205 135378-08-4 C26H38O12 = 542.57 5mg QQ客服:3257982914
    4''-Hydroxyisojasminin; 4''-Hydroxyisojasminin CFN89089 135378-09-5 C26H38O13 = 558.57 5mg QQ客服:3257982914
    Nudifloside C ; Nudifloside C CFN89204 297740-99-9 C26H38O12 = 542.57 5mg QQ客服:1413575084
    Nudifloside D ; Nudifloside D CFN96699 454212-54-5 C27H42O13 = 574.62 5mg QQ客服:3257982914
    莫诺苷; Morroniside CFN98161 25406-64-8 C17H26O11 = 406.38 20mg QQ客服:3257982914
    7-O-甲基莫诺苷; 7-O-Methyl morroniside CFN93651 41679-97-4 C18H28O11 = 420.4 5mg QQ客服:1413575084
    7-乙氧基莫诺苷; 7-O-ethyl-morroniside CFN93652 945721-10-8 C19H30O11 = 434.4 5mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产