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  • 断氧化马钱子苷

    Secoxyloganin

    断氧化马钱子苷
    产品编号 CFN98996
    CAS编号 58822-47-2
    分子式 = 分子量 C17H24O11 = 404.4
    产品纯度 >=98%
    物理属性 Solid
    化合物类型 Iridoids
    植物来源 The vines of Lonicera japonica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    断氧化马钱子苷 CFN98996 58822-47-2 10mg QQ客服:3257982914
    断氧化马钱子苷 CFN98996 58822-47-2 20mg QQ客服:3257982914
    断氧化马钱子苷 CFN98996 58822-47-2 50mg QQ客服:3257982914
    断氧化马钱子苷 CFN98996 58822-47-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Washington State University (USA)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Istanbul University (Turkey)
  • University Medical Center Mainz (Germany)
  • University of Parma (Italy)
  • University of Eastern Finland (Finland)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • University of Dicle (Turkey)
  • St. Jude Children Research Hospital (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Cincinnati (USA)
  • Periyar University (India)
  • Texas A&M University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharm Biol.2017, 55(1):360-366
  • J Drug Delivery Science and Tech.2022, 67:102957.
  • Int J Mol Sci.2020, 21(6):2190.
  • Tissue Cell.2022, 75:101728.
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • Int J Mol Sci.2019, 20(23):E6071
  • Molecules.2021, 26(4):816.
  • Food Chem.2018, 252:207-214
  • Nutr Res Pract.2023, 17(4):670-681.
  • J Cell Mol Med.2021, 25(5):2645-2654.
  • Heliyon.2023, 9:e21652.
  • J Appl Biol Chem2021, 64(3):245-251.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • J Med Food.2021, 24(2):151-160.
  • Environ Toxicol.2021, doi: 10.1002
  • Journal of Third Military Medical University2019, 41(2):110-115
  • TCI CO.2019, US20190151281A1
  • Biochemical Systematics and Ecology2018, 81
  • Biomimetics (Basel).2022, 7(4):154.
  • Nutrients.2019, 12(1)
  • J Pharmaceut Biomed2020, 182:113110
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • Antioxidants (Basel).2022, 11(10):1929.
  • ...
  • 生物活性
    Description: Secoxyloganin possesses hepato- protective, cytotoxic, and antibacterial activities, it has the perfect protective effect on PRRSV infected cell and with the minimum protection concentration of 6. 25 Âμg/mL.
    Targets: Antifection
    In vitro:
    Nat Prod Res. 2013;27(18):1677-81.
    Cytotoxic activity of Guettarda pohliana Müll. Arg. (Rubiaceae).[Pubmed: 23387288]

    METHODS AND RESULTS:
    The cytotoxic activity of crude extracts and their fractions from leaves and roots of G. pohliana was assessed against nine human cancer cell lines: melanoma (UACC-62), breast (MCF-7), breast expressing the multidrug resistance phenotype (NCI-ADR), lung (NCI-460), prostate (PCO-3), kidney (786-0), ovarian (OVCAR), colon (HT-29) and leukaemia (K-562). The hexane fraction from leaves (HL) and ethyl acetate (EAR), chloroform (CR) and hydromethanolic (HMR) fractions from roots were the most active fractions against K-562 with GI₅₀ values being lower than 1 μg mL⁻1. Also, CR and HMR fractions were active against UACC-62 cell line in the same order of magnitude.
    CONCLUSIONS:
    The phytochemical study of the CR fraction allowed identifying the known iridoids secoxyloganin, sweroside and loganin.
    Food Chem. 2013 May 1;138(1):327-33.
    Screening and identification of the antibacterial bioactive compounds from Lonicera japonica Thunb. leaves.[Pubmed: 23265495]
    Our aim was to screen for antibacterial bioactive compounds from Lonicera japonica leaves. Staphylococcus aureus and Escherichia coli were used as the indicator bacteria. Bacteriostatic assay-guided extraction and stepwise partitioning of the samples yielded five compounds of interest.
    METHODS AND RESULTS:
    Antimicrobial activities of the compounds were determined using a disk diffusion assay. Extracts, fractions, and compounds from L. japonica leaves possessed considerable antibacterial activities against the tested bacterial strains and the most active fraction was attributed to J3B2, which primarily contained 3,5-di-O-caffeoylquinic acid and 4,5-di-O-caffeoylquinic acid. Meanwhile, five bacteriostatic constituents were isolated (3-O-caffeoylquinic acid, secoxyloganin, luteoloside, 3,5-di-O-caffeoylquinic acid and 4,5-di-O-caffeoylquinic acid), among which, secoxyloganin was isolated for the first time from leaves. The antibacterial activity of the compounds was in the order of 3,5-bis-O-caffeoyl quinic acid, 4,5-bis-O-caffeoylquinic acid, luteoloside>3-O-caffeoylquinic acid>secoxyloganin.
    CONCLUSIONS:
    Our results suggested that the phenolic compounds might significantly contribute to antibacterial activity and were the most responsible for the bacteriostatic activity of L. japonica leaves.
    Chemistry & Industry of Forest Products, 2005, 25(3):29-32.
    CHEMICAL CONSTITUENTS IN FLOWER BUDS OF LONICERA JAPONICA THUNB.[Reference: WebLink]
    Active constituents were isolated from the flower buds of Lonicera japonica Thunb. They were extracted with 70 % alcohol, then fractioned successively with petroleum ether, ethyl acetate and n-butanol.
    METHODS AND RESULTS:
    The ethyl acetate part was repeatedly chromatographed on silica gel column and purified with ODS column. Nine compounds, namely loganin(1),sweroside(2),7-epi-vogeloside(3),7-epi-loganin(4),secoxyloganin(5),caffeic acid(6),p-hydroxybenzoic acid(7), β-sitosterol(8) and daucosterol (9) were obtained and their structures were deduced by comparison of their physico-chemical properties and spectral data with those of reference data.
    CONCLUSIONS:
    Compounds 4,5,6,7 were found for the first time in the flower buds of L. japonica Thunb., and compounds 1,4,5 were found to possess hepato- protective effect.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4728 mL 12.364 mL 24.728 mL 49.456 mL 61.82 mL
    5 mM 0.4946 mL 2.4728 mL 4.9456 mL 9.8912 mL 12.364 mL
    10 mM 0.2473 mL 1.2364 mL 2.4728 mL 4.9456 mL 6.182 mL
    50 mM 0.0495 mL 0.2473 mL 0.4946 mL 0.9891 mL 1.2364 mL
    100 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.4946 mL 0.6182 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Periclymenosidic acid; Periclymenosidic acid CFN95686 96681-56-0 C32H42O18 = 714.7 5mg QQ客服:2159513211
    女贞甙; Ligustroside CFN98484 35897-92-8 C25H32O12 = 524.5 5mg QQ客服:215959384
    橄榄苦苷元; Oleuropein aglycone CFN91625 31773-95-2 C19H22O8 = 378.4 5mg QQ客服:1457312923
    橄榄苦苷; Oleuropein CFN98416 32619-42-4 C25H32O13 = 540.5 20mg QQ客服:2056216494
    Oleuroside; Oleuroside CFN95099 116383-31-4 C25H32O13 = 540.5 20mg QQ客服:2159513211
    Fraxamoside; Fraxamoside CFN98417 326594-34-7 C25H30O13 = 538.5 5mg QQ客服:215959384
    女贞苷G13; GL3 CFN80115 60037-39-0 C48H64O27 = 1073.02 20mg QQ客服:1413575084
    特女贞苷; Nuezhenide CFN98623 39011-92-2 C31H42O17 = 686.7 20mg QQ客服:2056216494
    新女贞苷; Neonuezhenide CFN89171 96382-91-1 C31H42O18 = 702.65 5mg QQ客服:1457312923
    Oleonuezhenide; Oleonuezhenide CFN99228 112693-21-7 C48H64O27 = 1073.0 10mg QQ客服:1457312923

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