Info: Read More
  • 中药标准品生产商,产品定制服务
  • Neoorthosiphol A

    Neoorthosiphol A

    Neoorthosiphol A
    产品编号 CFN95447
    CAS编号 243448-72-8
    分子式 = 分子量 C38H44O12 = 692.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The branches of Platycladus orientalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Neoorthosiphol A CFN95447 243448-72-8 1mg QQ客服:3257982914
    Neoorthosiphol A CFN95447 243448-72-8 5mg QQ客服:3257982914
    Neoorthosiphol A CFN95447 243448-72-8 10mg QQ客服:3257982914
    Neoorthosiphol A CFN95447 243448-72-8 20mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Pennsylvania State University (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Toulouse (France)
  • Washington State University (USA)
  • Texas A&M University (USA)
  • Hamdard University (India)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Korea Food Research Institute(KFRI) (Korea)
  • FORTH-IMBB (Greece)
  • Griffith University (Australia)
  • Universidad Industrial de Santander (Colombia)
  • University of Bordeaux (France)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University of Maryland (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cell Prolif.2021, 54(8):e13083.
  • Mol Pharm.2018, 15(8):3285-3296
  • Metabolites.2020, 10(12):497.
  • Plants (Basel).2020, 9(11):1555.
  • J of Apicultural Research2020, 10.1080
  • Appl. Sci. 2021, 11(8),3437.
  • J Pharmacol Sci.2021, 147(2):184-191.
  • J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
  • Antioxidants (Basel).2020, 9(11):1121.
  • Acta Physiologiae Plantarum2015, 37:1736
  • Enzyme and Microbial Technology2022, 110002.
  • Life Sci.2019, 216:259-270
  • Int J Mol Sci.2022, 23(21):12816.
  • LWT-Food Sci Technol2020, 109163
  • J Health Sci Med Res.2023, 31584.
  • J Nat Med.2022, 76(1):59-67.
  • Phytomedicine.2019, 61:152813
  • Biosci. Rep.2020, 10.1024
  • J.Food Processing & Preservation2022, jfpp.16666
  • Phytomedicine.2018, 41:62-66
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Food Control2022, 132:108434.
  • Int J Mol Med.2016, 37(2):501-8
  • ...
  • 生物活性
    Description: Neoorthosiphol A inhibits rat thoracic aortic systolic response. Neoorthosiphol A shows antiprolifer-ative activity against highly hepatic metastatic colon 26-L5 carcinoma and the human HT-1080 fibrosarcoma cell line.
    In vitro:
    Chem Pharm Bull (Tokyo) . 2003 Mar;51(3):268-275.
    Highly-oxygenated isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia and their nitric oxide inhibitory activity[Pubmed: 12612410]
    From the methanolic extract of Indonesian Orthosiphon stamineus, nine new highly-oxygenated isopimarane-type diterpenes [7-O-deacetylorthosiphol B (1), 6-hydroxyorthosiphol B (2), 3-O-deacetylorthosiphol I (3), 2-O-deacetylorthosiphol J (4), siphonols A-E (5-9)] have been isolated together with nine known diterpenes [orthosiphols H (10), K (11), M (12) and N (13); staminols A (14) and B (15); neoorthosiphols A (16) and B (17); norstaminol A (18)]. Their structures were determined based on the spectroscopic data. The isolated diterpenes inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 4-7, 9, 10, 14, and 17 showed inhibitory activities more potent (IC(50), 10.8-25.5 microM) than a positive control N(G)-monomethyl-L-arginine (L-NMMA; IC(50), 26.0 microM).
    J Nat Prod . 2001 May;64(5):592-596.
    Five novel highly oxygenated diterpenes of Orthosiphon stamineus from Myanmar[Pubmed: 11374950]
    Five novel highly oxygenated diterpenes, orthosiphols K (1), L (2), M (3), and N (4) and norstaminone A (5), were isolated from the aerial part of Orthosiphon stamineus, together with three known diterpenes, orthosiphols A (6) and B (7) and neoorthosiphol A (8). Orthosiphol L (2) is an isopimarane-type diterpene with a hydroxyl group at C-12, which supports the biogenesis of staminane-type diterpenes, i.e., migration of a vinylic group from C-13 of isopimarane to C-12. Norstaminone A (5) has a staminane carbon framework and supports the biosynthetic pathway from staminols to norstaminols via staminolactones. All the isolated compounds showed mild to weak antiproliferative activities toward highly liver metastatic colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cell lines.
    In vivo:
    Chem Pharm Bull (Tokyo). 2000 Mar;48(3):433-435.
    Indonesian medicinal plants. XXIII. Chemical structures of two new migrated pimarane-type diterpenes, neoorthosiphols A and B, and suppressive effects on rat thoracic aorta of chemical constituents isolated from the leaves of Orthosiphon aristatus (Lamiaceae)[Pubmed: 10726872]
    Two novel migrated pimarane-type diterpenes named neoorthosiphols A (1) and B (2) were isolated from the water decoction of the leaves of Orthosiphon aristatus (Lamiaceae), which has been prescribed in Javanese traditional medicine (jamu) for the treatment of hypertension, etc. The absolute chemical structures have been elucidated on the basis of physicochemical properties. It has been found that two migrated pimarane-type diterpenes (1, 2), four isopimarane-type diterpenes (3, 4, 5, 6), three benzochromenes (7, 8, 9) and two flavones (12, 13) exhibit a suppressive effect on contractile responses in rat thoracic aorta, among thirteen chemical constituents (1-13) isolated from the leaves.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4434 mL 7.2171 mL 14.4342 mL 28.8684 mL 36.0855 mL
    5 mM 0.2887 mL 1.4434 mL 2.8868 mL 5.7737 mL 7.2171 mL
    10 mM 0.1443 mL 0.7217 mL 1.4434 mL 2.8868 mL 3.6085 mL
    50 mM 0.0289 mL 0.1443 mL 0.2887 mL 0.5774 mL 0.7217 mL
    100 mM 0.0144 mL 0.0722 mL 0.1443 mL 0.2887 mL 0.3609 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Neoorthosiphol A; Neoorthosiphol A CFN95447 243448-72-8 C38H44O12 = 692.8 10mg QQ客服:3257982914
    15-异海松烯-8,18-二醇; 15-Isopimarene-8,18-diol CFN97214 73002-86-5 C20H34O2 = 306.5 5mg QQ客服:2056216494
    Toonaciliatin M; Toonaciliatin M CFN92899 93930-04-2 C20H32O3 = 320.47 5mg QQ客服:2056216494
    8(14),15-异海松二烯-3,18-二醇; 8(14),15-Isopimaradiene-3,18-diol CFN97003 59219-64-6 C20H32O2 = 304.5 5mg QQ客服:3257982914
    Hugorosenone; Hugorosenone CFN92876 217096-49-6 C20H30O2 = 302.4 5mg QQ客服:215959384
    Yucalexin P-17; Yucalexin P-17 CFN96300 119642-82-9 C20H30O3 = 318.5 5mg QQ客服:2056216494
    长白楤木酸; Continentalic acid CFN90861 19889-23-7 C20H30O2 = 302.5 20mg QQ客服:1457312923
    海松酸; Pimaric acid CFN99382 127-27-5 C20H30O2 = 302.5 5mg QQ客服:2056216494
    异海松酸; Isopimaric acid CFN97723 5835-26-7 C20H30O2 = 302.46 5mg QQ客服:2056216494
    玫瑰菌素; Rosenonolactone CFN98805 508-71-4 C20H28O3 = 316.4 5mg QQ客服:3257982914

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产