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  • Microgrewiapine A

    Microgrewiapine A

    Microgrewiapine A
    产品编号 CFN95125
    CAS编号 1420777-30-5
    分子式 = 分子量 C17H29NO = 263.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The leaves of Microcos paniculata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Microgrewiapine A CFN95125 1420777-30-5 1mg QQ客服:215959384
    Microgrewiapine A CFN95125 1420777-30-5 5mg QQ客服:215959384
    Microgrewiapine A CFN95125 1420777-30-5 10mg QQ客服:215959384
    Microgrewiapine A CFN95125 1420777-30-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Bordeaux (France)
  • University of Maryland (USA)
  • Yale University (USA)
  • Chulalongkorn University (Thailand)
  • VIT University (India)
  • Istanbul University (Turkey)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Universidad de Buenos Aires (Argentina)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • The University of Newcastle (Australia)
  • Universidade da Beira Interior (Germany)
  • University of Toulouse (France)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Universite de Lille1 (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Natural Product Communications2020, doi: 10.1177.
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Molecules.2020, 25(23):5609.
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Eur J Pharmacol.2021, 906:174220.
  • Sci Rep.2019, 9(1):4342
  • Int Immunopharmacol. 2020, 83:106403.
  • GENENCELL2023, 25:4356740
  • Kor. J. Herbol.2019, 34(2):59-66
  • Foods.2020, 9(10):1348.
  • Phytother Res.2019, 33(3):676-689
  • Separations2023, 10(11), 567;
  • J Ethnopharmacol.2017, 198:87-90
  • J Food Sci Technol.2022, 59(1):212-219.
  • Exp Parasitol.2018, 194:67-78
  • Rev. Chim.2020, 71(3),558-564
  • Molecules 2021, 26(4),1092.
  • Sci Rep.2023, 13(1):14594.
  • Nutrients.2021, 13(1):254.
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • BMC Plant Biol.2018, 18(1):122
  • Srinagarind Medical Journal2019, 34(1)
  • Phytomedicine.2022, 100:154085.
  • ...
  • 生物活性
    Description: Microgrewiapine A is a selective cytotoxic agent for colon cancer cells over normal colon cells and to exhibit nicotinic receptor antagonistic activity for both the hα3β4 and hα4β2 receptor subtypes.
    Targets: hα3β4 receptor | hα4β2 receptor
    In vitro:
    J Nat Prod. 2013 Feb 22;76(2):243-9.
    Alkaloids from Microcos paniculata with cytotoxic and nicotinic receptor antagonistic activities.[Pubmed: 23327794]
    Microcos paniculata is a large shrub or small tree that grows in several countries in South and Southeast Asia.
    METHODS AND RESULTS:
    In the present study, three new piperidine alkaloids, microgrewiapines A, microgrewiapine B, microgrewiapine C (1-3), as well as three known compounds, inclusive of microcosamine A (4), 7'-(3',4'-dihydroxyphenyl)-N-[4-methoxyphenyl)ethyl]propenamide (5), and liriodenine (6), were isolated from cytotoxic fractions of the separate chloroform-soluble extracts of the stem bark, branches, and leaves of M. paniculata. Compounds 1-6 and 1a (microgrewiapine A 3-acetate) showed a range of cytotoxicity values against the HT-29 human colon cancer cell line. When evaluated for their effects on human α3β4 or α4β2 nicotinic acetylcholine receptors (nAChRs), several of these compounds were shown to be active as nAChR antagonists.
    CONCLUSIONS:
    As a result of this study, microgrewiapine A (1) was found to be a selective cytotoxic agent for colon cancer cells over normal colon cells and to exhibit nicotinic receptor antagonistic activity for both the hα3β4 and hα4β2 receptor subtypes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7965 mL 18.9825 mL 37.9651 mL 75.9301 mL 94.9127 mL
    5 mM 0.7593 mL 3.7965 mL 7.593 mL 15.186 mL 18.9825 mL
    10 mM 0.3797 mL 1.8983 mL 3.7965 mL 7.593 mL 9.4913 mL
    50 mM 0.0759 mL 0.3797 mL 0.7593 mL 1.5186 mL 1.8983 mL
    100 mM 0.038 mL 0.1898 mL 0.3797 mL 0.7593 mL 0.9491 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-Epiturraeanthin; 3-Epiturraeanthin CFN98218 22415-24-3 C32H50O5 = 514.8 5mg QQ客服:2159513211
    莴苣苦素; Lactupicrin CFN70433 65725-11-3 C23H22O7 = 410.4 5mg QQ客服:2159513211
    Merucathine; Merucathine CFN00056 107673-74-5 C11H15NO = 177.25 5mg QQ客服:215959384
    硫酸胆碱; Choline sulphate CFN00067 4858-96-2 C5H13NO4S = 183.23 5mg QQ客服:1457312923

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