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  • 灵芝酸K

    Ganoderic acid K

    灵芝酸K
    产品编号 CFN92057
    CAS编号 104700-95-0
    分子式 = 分子量 C32H46O9 = 574.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸K CFN92057 104700-95-0 1mg QQ客服:2159513211
    灵芝酸K CFN92057 104700-95-0 5mg QQ客服:2159513211
    灵芝酸K CFN92057 104700-95-0 10mg QQ客服:2159513211
    灵芝酸K CFN92057 104700-95-0 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Mahatma Gandhi University (India)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • The Institute of Cancer Research (United Kingdom)
  • Medical University of South Carolina (USA)
  • Uniwersytet Gdański (Poland)
  • National Research Council of Canada (Canada)
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  • John Innes Centre (United Kingdom)
  • University of Perugia (Italy)
  • Chang Gung University (Taiwan)
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  • University of Dicle (Turkey)
  • Center for protein Engineering (CIP) (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • Journal of Ginseng Research2022, j.jgr.2022.09.005.
  • J Sep Sci.2021, 44(22):4064-4081.
  • Ind Crops Prod.2014, 62:173-178
  • Appl. Sci.2020, 10(8),2804
  • Nat Commun.2021, 12(1):681.
  • Biol Pharm Bull.2017, 40(6):797-806
  • Separations2021, 8(7),90.
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • J Bone Miner Res.2017, 32(12):2415-2430
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • Planta Med.2019, 85(9-10):766-773
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • Pharmaceuticals.2022, 15(4), 402.
  • Applied Biological Chemistry2023, 66:42.
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Phytochem Anal.2016, 27(5):296-303
  • Appl. Sci. 2021, 11(1),14.
  • Int J Mol Sci.2022, 23(1):538.
  • Molecules.2023, 28(7):3039.
  • Sci Rep.2023, 13(1):7475.
  • ...
  • 生物活性
    Description: Ganoderic acid K is an angiotensin-converting enzyme inhibitor. It has anti-tumor, and anti-inflammatory activities.
    Targets: Immunology & Inflammation related
    In vitro:
    Phytomedicine. 2010 Jul;17(8-9):606-13.
    Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells.[Pubmed: 20092987]

    METHODS AND RESULTS:
    To elucidate the cytotoxicity mechanism of Ganoderma triterpenes, a chemoproteomic study using five purified ganoderic acids, ganoderic acid F (GAF), Ganoderic acid K (GAK), ganoderic B (GAB), ganoderic acid D (GAD) and ganoderic acid AM1 (GAAM1) was conducted. GAF, GAK, GAB, GAD and GAAM1 treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with IC(50) values of 19.5+/-0.6 microM, 15.1+/-0.5 microM, 20.3+/-0.4 microM, 17.3+/-0.3 microM, 19.8+/-0.7 microM, respectively. The protein expression profiles of HeLa cells treated with each ganoderic acid at dose of 15 microM for 48 h were checked using two-dimensional electrophoresis (2-DE). The possible target-related proteins of ganoderic acids, i.e. proteins with same change tendency in all five ganoderic acids-treated groups compared with control, were identified using MALDI-TOF MS/MS. Twelve proteins including human interleukin-17E, eukaryotic translation initiation factor 5A (eIF5A), peroxiredoxin 2, ubiquilin 2, Cu/Zn-superoxide dismutase, 14-3-3 beta/alpha, TPM4-ALK fusion oncoprotein type 2, PP2A subunit A PR65-alpha isoform, nucleobindin-1, heterogeneous nuclear ribonucleoprotein K, reticulocalbin 1 and chain A of DJ-1 protein were identified.
    CONCLUSIONS:
    Ganoderic acids might exert their cytotoxicity by altering proteins involved in cell proliferation and/or cell death, carcinogenosis, oxidative stress, calcium signaling and ER stress.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.74 mL 8.7002 mL 17.4004 mL 34.8008 mL 43.501 mL
    5 mM 0.348 mL 1.74 mL 3.4801 mL 6.9602 mL 8.7002 mL
    10 mM 0.174 mL 0.87 mL 1.74 mL 3.4801 mL 4.3501 mL
    50 mM 0.0348 mL 0.174 mL 0.348 mL 0.696 mL 0.87 mL
    100 mM 0.0174 mL 0.087 mL 0.174 mL 0.348 mL 0.435 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Ganoweberianic acid E; Ganoweberianic acid E CFN95504 1309931-90-5 C32H44O9 = 572.7 5mg QQ客服:1413575084
    12beta-Acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20-diene-26-oic acid; 12beta-Acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20-diene-26-oic acid CFN95468 1085338-75-5 C32H42O9 = 570.7 5mg QQ客服:2056216494
    12beta-Acetoxy-3,7,11,15,23-pentaoxo-lanost-8,20-dien-26-oic acid; 12beta-Acetoxy-3,7,11,15,23-pentaoxo-lanost-8,20-dien-26-oic acid CFN95505 1309931-91-6 C32H40O9 = 568.7 5mg QQ客服:215959384
    去乙酰基灵芝酸F; Deacetyl ganoderic acid F CFN90746 100665-44-9 C30H40O8 = 528.6 5mg QQ客服:2056216494
    灵芝酸F; Ganoderic acid F CFN92055 98665-15-7 C32H42O9 = 570.7 20mg QQ客服:215959384
    灵芝酸F甲酯; Methyl ganoderate F CFN95584 98665-08-8 C33H44O9 = 584.7 5mg QQ客服:3257982914
    12beta-Acetoxy-7beta-hydroxy-3,11,15,23-tetraoxo-5alpha-lanosta-8,20-dien-26-oic acid; 12beta-Acetoxy-7beta-hydroxy-3,11,15,23-tetraoxo-5alpha-lanosta-8,20-dien-26-oic acid CFN95515 N/A C32H42O9 = 570.7 5mg QQ客服:1457312923
    灵芝烯酸K; Ganoderenic acid K CFN95469 942950-94-9 C32H44O9 = 572.7 10mg QQ客服:1413575084
    灵芝酸C6; Ganoderic acid C6 CFN92290 105742-76-5 C30H42O8 = 530.7 20mg QQ客服:2159513211
    灵芝酸C6甲酯; Methyl ganoderate C6 CFN92292 105742-81-2 C31H44O8 = 544.7 5mg QQ客服:1413575084

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