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  • 甲基赤芝萜酮

    Methyllucidone

    甲基赤芝萜酮
    产品编号 CFN98012
    CAS编号 19956-54-8
    分子式 = 分子量 C16H14O4 = 270.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The roots of Lindera pipericarpa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甲基赤芝萜酮 CFN98012 19956-54-8 1mg QQ客服:2159513211
    甲基赤芝萜酮 CFN98012 19956-54-8 5mg QQ客服:2159513211
    甲基赤芝萜酮 CFN98012 19956-54-8 10mg QQ客服:2159513211
    甲基赤芝萜酮 CFN98012 19956-54-8 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Leipzig (Germany)
  • Celltrion Chemical Research Institute (Korea)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Chiang Mai University (Thailand)
  • University of Wisconsin-Madison (USA)
  • Universidad Industrial de Santander (Colombia)
  • Indian Institute of Science (India)
  • University of Zurich (Switzerland)
  • Stanford University (USA)
  • University of Toulouse (France)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Shanghai Institute of Organic Chemistry (China)
  • University of Ioannina (Greece)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11:S585-91
  • Int J Mol Sci.2021, 22(21):11836.
  • Sci Rep.2016, 6:25094
  • Drug Test Anal.2018, 10(10):1579-1589
  • The Korea Journal of Herbology2020, 35(3):33-45.
  • Industrial Crops and Products2022, 186:115298
  • Int J Mol Sci.2022, 23(20):12516.
  • Food Funct.2022, 13(23):12105-12120.
  • J Inflamm Res.2022, 15:5347-5359.
  • LWT2021, 147:111620.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Biomedicines.2020, 8(11):486.
  • Food Research International2023, 113792.
  • Sci Rep.2019, 9:12132
  • Antioxidants (Basel).2019, 8(8):E307
  • Plant Physiol Biochem.2023, 202:107913.
  • Nutrients.2019, 11(4):E936
  • Antiviral Res.2013, 98(3):386-93
  • Sci Rep.2019, 9(1):6429
  • Eur J Pharmacol.2018, 832:96-103
  • Journal of Plant Growth Regulation2022, 10705-2.
  • Appl. Sci.2022, 12(4), 2032.
  • J. Traditional Thai Medical Res. 2022,8(1):1-14.
  • ...
  • 生物活性
    Description: Methyllucidone may have a neuroprotective potential via inhibition of neurotoxic microglial activation implicated in neurodegeneration.It can strongly inhibit the growth of human cancer cells and colon tumor xenografted in nude mice, the anti-tumor effects are further confirmed with caspase-3 activation and degradation of PARP. Methyllucidone shows 85% antifungal activity at 50 against the disease wheat leaf rust.
    Targets: NO | IL Receptor | TNF-α | NF-kB | Akt | p38MAPK | ERK | Caspase | PARP | Antifection
    In vitro:
    Eur J Pharmacol. 2012 Sep 5;690(1-3):4-12.
    Neuroprotective effect of methyl lucidone against microglia-mediated neurotoxicity.[Pubmed: 22683871]
    The microglial regulatory mechanism of Methyllucidone, a cyclopentenedione isolated from the stem bark of Lindera erythrocarpa Makino, was investigated in the present study.
    METHODS AND RESULTS:
    Methyllucidone treatment (0.1-10 μM) significantly inhibited lipopolysaccharide (LPS, 100 ng/ml, 24 h)-stimulated nitric oxide (NO) production in a dose-dependent manner in both primary cortical microglia and BV-2 cell line. Moreover, it strongly inhibited LPS-stimulated secretion of pro-inflammatory cytokines, such as interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α). Methyllucidone treatment markedly induced down-regulation of LPS-induced nuclear translocation of nuclear factor κB (NF-κB) through preventing the degradation of the inhibitory protein IκBα. In addition, phosphorylation of Akt and mitogen-activated protein kinases (MAPKs) such as extracellular signal-regulated kinase (ERK) and p38 kinases were also suppressed by Methyllucidone. The cell viabilities of HT-22 neurons were significantly attenuated by treatment of the conditioned media containing neurotoxic secretary molecules from LPS-stimulated microglia. However, Methyllucidone significantly blocked neuronal cell death induced by microglial conditioned media. These neuroprotective effects of Methyllucidone were also confirmed in a neuron-microglia co-culture system using EGFP-transfected B35 neuroblastoma cell line.
    CONCLUSIONS:
    Taken together, these results suggest that Methyllucidone may have a neuroprotective potential via inhibition of neurotoxic microglial activation implicated in neurodegeneration.
    Bioorg Med Chem. 2005 Nov 15;13(22):6182-7.
    Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino.[Pubmed: 16055336]
    The microglial regulatory mechanism of Methyllucidone, a cyclopentenedione isolated from the stem bark of Lindera erythrocarpa Makino, was investigated in the present study.
    METHODS AND RESULTS:
    Methyllucidone treatment (0.1-10 μM) significantly inhibited lipopolysaccharide (LPS, 100 ng/ml, 24 h)-stimulated nitric oxide (NO) production in a dose-dependent manner in both primary cortical microglia and BV-2 cell line. Moreover, it strongly inhibited LPS-stimulated secretion of pro-inflammatory cytokines, such as interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α). Methyllucidone treatment markedly induced down-regulation of LPS-induced nuclear translocation of nuclear factor κB (NF-κB) through preventing the degradation of the inhibitory protein IκBα. In addition, phosphorylation of Akt and mitogen-activated protein kinases (MAPKs) such as extracellular signal-regulated kinase (ERK) and p38 kinases were also suppressed by Methyllucidone. The cell viabilities of HT-22 neurons were significantly attenuated by treatment of the conditioned media containing neurotoxic secretary molecules from LPS-stimulated microglia. However, Methyllucidone significantly blocked neuronal cell death induced by microglial conditioned media. These neuroprotective effects of Methyllucidone were also confirmed in a neuron-microglia co-culture system using EGFP-transfected B35 neuroblastoma cell line.
    CONCLUSIONS:
    Taken together, these results suggest that Methyllucidone may have a neuroprotective potential via inhibition of neurotoxic microglial activation implicated in neurodegeneration.
    J.Korean Soc. Agr. Biotechnol., 2003,46(2):150-3.
    Isolation of Antifungal Active Compounds from the Leaves of Lindera erythrocarpa.[Reference: WebLink]

    METHODS AND RESULTS:
    Methanol extract obtained from Lindera erythocarpa leaves was successively fractionated with n-hexane, ethylacetate, n-butanol, and . From ethylacetate fraction, an active fraction was isolated through repeated silica gel column chromatography and recrystallization, and was identified as a stereoisomer complex of Methyllucidone by MS and MMR analyses.
    CONCLUSIONS:
    The complex showed 85% antifungal activity at 50 against the disease wheat leaf rust.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6996 mL 18.498 mL 36.9959 mL 73.9919 mL 92.4898 mL
    5 mM 0.7399 mL 3.6996 mL 7.3992 mL 14.7984 mL 18.498 mL
    10 mM 0.37 mL 1.8498 mL 3.6996 mL 7.3992 mL 9.249 mL
    50 mM 0.074 mL 0.37 mL 0.7399 mL 1.4798 mL 1.8498 mL
    100 mM 0.037 mL 0.185 mL 0.37 mL 0.7399 mL 0.9249 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    赤芝酮; Lucidone CFN98011 19956-53-7 C15H12O4 = 256.3 5mg QQ客服:3257982914
    甲基赤芝萜酮; Methyllucidone CFN98012 19956-54-8 C16H14O4 = 270.3 5mg QQ客服:3257982914
    乙基赤芝酮; Ethyllucidone CFN99308 1195233-59-0 C17H16O4 = 284.3 5mg QQ客服:1413575084
    乌药环戊烯二酮; Linderone CFN99837 1782-79-2 C16H14O5 = 286.3 5mg QQ客服:2056216494
    乌药环戊烯二酮甲醚; Methyllinderone CFN98631 3984-73-4 C17H16O5 = 300.3 5mg QQ客服:2056216494

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