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  • 米林酸甲酯

    Methyl nomilinate

    产品编号 CFN95576
    CAS编号 77887-51-5
    分子式 = 分子量 C29H38O10 = 546.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruits of Citrus reticulata Blanco.
    产品名称 产品编号 CAS编号 包装 QQ客服
    米林酸甲酯 CFN95576 77887-51-5 1mg QQ客服:2056216494
    米林酸甲酯 CFN95576 77887-51-5 5mg QQ客服:2056216494
    米林酸甲酯 CFN95576 77887-51-5 10mg QQ客服:2056216494
    米林酸甲酯 CFN95576 77887-51-5 20mg QQ客服:2056216494
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    PMID: 30417089
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  • 生物活性
    Description: Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
    In vitro:
    Toxicol In Vitro . 2012 Oct;26(7):1216-1223.
    Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro[Pubmed: 22728232]
    Limonoids are triterpenoids found in citrus and possess cancer preventive properties in in vitro and in vivo assays. Although several mechanisms for the chemopreventive properties of limonoids have been postulated, the specific mechanisms involved in the anti-cancer effects have not been explored. In the present study, limonoids, including methyl nomilinate, isoobacunoic acid, isolimonexic acid (ILNA), and limonexic acid (LNA), were purified, identified by LC-MS and NMR spectral data and evaluated for their biological effects on SW480 human colon adenocarcinoma cells. Methyl nomilinate was the most potent inhibitor of cell metabolic activity in MTT and EdU incorporation assays. These limonoids did not affect apoptotic markers such as caspase-3 and PARP, but methyl nomilinate treatment resulted in significant induction of G0/G1 cell cycle arrest. Furthermore, methyl nomilinate suppressed CDK4/6 and cyclin D3 and the expression of CDK inhibitors. Taken together, the results suggest inhibition of cell proliferation by methyl nomilinate occurs due to G1 cell cycle arrest, indicating that methyl nomilinate has potential as a chemopreventive agent.
    Eur J Pharmacol . 2011 Nov 16;670(1):44-49.
    Structure-function relationships of citrus limonoids on p38 MAP kinase activity in human aortic smooth muscle cells[Pubmed: 21924259]
    Limonoids, abundantly present in citrus fruits, have potential role in reducing risk of different type of cancer. In the present study, we hypothesized that seven structurally different limonoids would involve in inflammatory pathway via modulating p38 MAP kinase activity at various extent in vascular smooth muscle cells. Results demonstrated that the different functional groups containing limonoids had differential effects on the p38 MAP kinase activity in human aortic smooth muscle cells. Among seven limonoids, nomilin exhibited the highest (38%) inhibition of p38 MAP kinase activity, followed by limonin (19%), deacetyl nomilin (19%), and defuran nomilin (17%). While defuran limonin and methyl nomilinate showed no significant decrease in p38 MAP kinase activity, obacunone significantly increased the p38 MAP kinase activity by 38%. Furthermore, TNF-α induced p38 MAP kinase activity in the smooth muscle cells was completely inhibited by nomilin. Thus our data provide the first evidence that nomilin is the potent natural inhibitor for p38 MAP kinase activity in human aortic smooth muscle cells. These data also suggest that a seven-membered A ring with acetoxy group, present in nomilin, seems to be essential for its inhibitory activity on p38 MAP kinase.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8295 mL 9.1475 mL 18.2949 mL 36.5898 mL 45.7373 mL
    5 mM 0.3659 mL 1.8295 mL 3.659 mL 7.318 mL 9.1475 mL
    10 mM 0.1829 mL 0.9147 mL 1.8295 mL 3.659 mL 4.5737 mL
    50 mM 0.0366 mL 0.1829 mL 0.3659 mL 0.7318 mL 0.9147 mL
    100 mM 0.0183 mL 0.0915 mL 0.1829 mL 0.3659 mL 0.4574 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Kihadanin A; Kihadanin A CFN92526 125276-62-2 C26H30O9 = 486.5 5mg QQ客服:215959384
    Kihadanin B; Kihadanin B CFN92527 73793-68-7 C26H30O9 = 486.5 5mg QQ客服:3257982914
    21,23-Dihydro-23-hydroxy-21-oxozapoterin ; 21,23-Dihydro-23-hydroxy-21-oxozapoterin CFN96926 426266-88-8 C26H30O10 = 502.51 5mg QQ客服:2056216494
    Kihadanin D; Kihadanin D CFN95482 2770024-83-2 C27H32O9 = 500.6 5mg QQ客服:2159513211
    黄柏酮; Obacunone CFN97233 751-03-1 C26H30O7 = 454.5 20mg QQ客服:3257982914
    Zapoterin; Zapoterin CFN98477 35796-71-5 C26H30O8 = 470.5 5mg QQ客服:2056216494
    诺米林; Nomilin CFN99935 1063-77-0 C28H34O9 = 514.56 20mg QQ客服:1457312923
    米林酸; Nomilinic acid CFN95559 35930-20-2 C28H36O10 = 532.6 5mg QQ客服:2159513211
    米林酸甲酯; Methyl nomilinate CFN95576 77887-51-5 C29H38O10 = 546.6 5mg QQ客服:1413575084
    罗旦梅交酯; Jangomolide CFN97510 93767-25-0 C26H28O8 = 468.5 5mg QQ客服:2159513211





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