蜂蜜曲菌素

Mellein

	产品编号	CFN97913
	CAS编号	480-33-1
	分子式 = 分子量	C₁₀H₁₀O₃ = 178.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The herbs of Goniothalamus griffithii
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
蜂蜜曲菌素	CFN97913	480-33-1	1mg	QQ客服：3257982914
蜂蜜曲菌素	CFN97913	480-33-1	5mg	QQ客服：3257982914
蜂蜜曲菌素	CFN97913	480-33-1	10mg	QQ客服：3257982914
蜂蜜曲菌素	CFN97913	480-33-1	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Northeast Normal University Changchun (China)

Utrecht University (Netherlands)

S.N.D.T. Women's University (India)

University of Fribourg (Switzerland)

University of Canterbury (New Zealand)

Copenhagen University (Denmark)

Uniwersytet Medyczny w ?odzi (Poland)

Sanford Burnham Prebys Medical Discovery Institute (USA)

Universidad Miguel Hernández (Spain)

National Research Council of Canada (Canada)

University of Wisconsin-Madison (USA)

Almansora University (Egypt)

Center for protein Engineering (CIP) (Belgium)

University of Illinois (USA)

More...

Description:

Standard reference

In vitro:

Appl Environ Microbiol. 2015 Jan;81(1):177-86.

An in planta-expressed polyketide synthase produces (R)-mellein in the wheat pathogen Parastagonospora nodorum.[Pubmed: 25326302 ]

Parastagonospora nodorum is a pathogen of wheat that affects yields globally.
METHODS AND RESULTS:
Previous transcriptional analysis identified a partially reducing polyketide synthase (PR-PKS) gene, SNOG_00477 (SN477), in P. nodorum that is highly upregulated during infection of wheat leaves. Disruption of the corresponding SN477 gene resulted in the loss of production of two compounds, which we identified as (R)-mellein and (R)-O-methylmellein. Using a Saccharomyces cerevisiae yeast heterologous expression system, we successfully demonstrated that SN477 is the only enzyme required for the production of (R)-mellein. This is the first identification of a fungal PKS that is responsible for the synthesis of (R)-mellein. The P. nodorum ΔSN477 mutant did not show any significant difference from the wild-type strain in its virulence against wheat. However, (R)-mellein at 200 μg/ml inhibited the germination of wheat (Triticum aestivum) and barrel medic (Medicago truncatula) seeds. Comparative sequence analysis identified the presence of mellein synthase (MLNS) homologues in several Dothideomycetes and two sodariomycete genera.
CONCLUSIONS:
Phylogenetic analysis suggests that the MLNSs in fungi and bacteria evolved convergently from fungal and bacterial 6-methylsalicylic acid synthases.

J Am Chem Soc. 2012 Jul 25;134(29):11924-7.

Synthesis of (R)-mellein by a partially reducing iterative polyketide synthase.[Pubmed: 22793256]

Disruption of the corresponding SN477 gene resulted in the loss of production of two compounds, which we identified as (R)-Mellein and (R)-O-methylMellein.
METHODS AND RESULTS:
Using a Saccharomyces cerevisiae yeast heterologous expression system, we successfully demonstrated that SN477 is the only enzyme required for the production of (R)-Mellein. This is the first identification of a fungal PKS that is responsible for the synthesis of (R)-Mellein. The P. nodorum ΔSN477 mutant did not show any significant difference from the wild-type strain in its virulence against wheat. However, (R)-Mellein at 200 μg/ml inhibited the germination of wheat (Triticum aestivum) and barrel medic (Medicago truncatula) seeds. Comparative sequence analysis identified the presence of Mellein synthase (MLNS) homologues in several Dothideomycetes and two sodariomycete genera.
CONCLUSIONS:
Phylogenetic analysis suggests that the MLNSs in fungi and bacteria evolved convergently from fungal and bacterial 6-methylsalicylic acid synthases.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
7-甲氧基-4-甲基香豆素; 7-Methoxy-4-methylcoumarin	CFN94405	2555-28-4	C₁₁H₁₀O₃ = 190.20	20mg	QQ客服：1457312923
6-甲氧基-4-甲基香豆素; 6-Methoxy-4-methylcoumarin	CFN94425	6295-35-8	C₁₁H₁₀O₃ = 190.20	20mg	QQ客服：1413575084
4,6-二甲氧基-2H-1-苯并吡喃-2-酮; 4,6-Dimethoxy-2H-1-benzopyran-2-one	CFN92538	53666-78-7	C₁₁H₁₀O₄ = 206.2	5mg	QQ客服：3257982914
4,6,7-三甲氧基-5-甲基香豆素; 4,6,7-Trimethoxy-5-methylcoumarin	CFN97084	62615-63-8	C₁₃H₁₄O₅ = 250.3	5mg	QQ客服：2159513211
结香素; Edgeworin	CFN96263	120028-43-5	C₁₈H₁₀O₆ = 322.3	5mg	QQ客服：2056216494
西瑞香素; Daphnoretin	CFN90329	2034-69-7	C₁₉H₁₂O₇ = 352.3	20mg	QQ客服：2159513211
异西瑞香素 B; Isodaphnoretin B	CFN96604	944824-29-7	C₂₀H₁₄O₈ = 382.32	5mg	QQ客服：2159513211
异双七叶内酯;异千金子素; Isoeuphorbetin	CFN95207	50677-55-9	C₁₈H₁₀O₈ = 354.3	5mg	QQ客服：215959384
Triumbelletin; Triumbelletin	CFN96473	131559-54-1	C₂₇H₁₄O₉ = 482.39	5mg	QQ客服：1457312923
蜂蜜曲菌素; Mellein	CFN97913	480-33-1	C₁₀H₁₀O₃ = 178.2	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.6117 mL	28.0584 mL	56.1167 mL	112.2334 mL	140.2918 mL
5 mM	1.1223 mL	5.6117 mL	11.2233 mL	22.4467 mL	28.0584 mL
10 mM	0.5612 mL	2.8058 mL	5.6117 mL	11.2233 mL	14.0292 mL
50 mM	0.1122 mL	0.5612 mL	1.1223 mL	2.2447 mL	2.8058 mL
100 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.1223 mL	1.4029 mL

蜂蜜曲菌素

Mellein

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