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  • 马枯星碱B

    Macusine B

    马枯星碱B
    产品编号 CFN96211
    CAS编号 6792-07-0
    分子式 = 分子量 C20H25N2O = 309.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Rauvolfia verticillata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    马枯星碱B CFN96211 6792-07-0 1mg QQ客服:3257982914
    马枯星碱B CFN96211 6792-07-0 5mg QQ客服:3257982914
    马枯星碱B CFN96211 6792-07-0 10mg QQ客服:3257982914
    马枯星碱B CFN96211 6792-07-0 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Lodz University of Technology (Poland)
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  • Universidad Industrial de Santander (Colombia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Pharm.2017, 14(9):3164-3177
  • Journal of Functional Foods2022, 99: 105331.
  • Phytomedicine.2019, 65:153089
  • Res Rep Urol.2022, 14:313-326.
  • Pharmaceuticals (Basel).2021, 14(8):742.
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • ACS Omega2020, 5,33,20825-20830
  • Evid Based Complement Alternat Med.2021, 2021:8707280.
  • Korean J of Crop Science2019, 452-458
  • Processes2021, 9(5),831.
  • Int Immunopharmacol.2019, 71:22-31
  • BMC Complement Med Ther. 2020, 20(1):94.
  • J Nat Med.2020, 74(1):65-75
  • Biomedicine & Pharmacotherapy2022, 153:113404.
  • Pharmacogn Mag.2015, 11:S585-91
  • Journal of Third Military Medical University2019, 41(2):110-115
  • Metabolites.2020, 10(12):497.
  • International Food Research Journal2018, 25(6):2560-2571
  • Molecules.2018, 23(2)
  • Front Microbiol.2022, 13:835463.
  • Cell Chem Biol.2019, 26(1):27-34
  • Food Science and Biotechnology2023, 2023:1007
  • iScience.2020, 23(2):100849.
  • ...
  • 生物活性
    Description: Macusine B is a dual inhibitor, has almost equal inhibitory activity on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
    Targets: AChR | BChE
    In vitro:
    Cell Physiol Biochem. 2015;37(5):1997-2011.
    New Indole Alkaloids from the Bark of Rauvolfia Reflexa and their Cholinesterase Inhibitory Activity.[Pubmed: 26584298 ]
    Rauvolfia reflexa is a member of the Apocynaceae family. Plants from the Apocynaceae family have been traditionally used in the treatment of age-related brain disorders。
    METHODS AND RESULTS:
    Two new indole alkaloids, rauvolfine C (1) and 3-methyl-10,11-dimethoxy-6-methoxycarbonyl-β-carboline (2), along with five known, macusine B (3), vinorine (4), undulifoline (5), isoresrpiline (6) and rescinnamine (7) were isolated from the bark of Rauvolfia reflexa. Cholinesterase inhibitory assay and molecular docking were performed to get insight of the inhibitory activity and molecular interactions of the compounds. The compounds showed good to moderate cholinesterase inhibitory activity with IC50 values in the range of 8.06 to 73.23 µM. Compound 7 was found to be the most potent inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Compounds 1, 2, 5 and 6 were found to be selective towards BChE, while compounds 3, 4 and 7 were dual inhibitors, having almost equal inhibitory activity on both AChE and BChE.
    CONCLUSIONS:
    Molecular docking revealed that compounds 6 and 7 interacted differently on AChE and BChE, by means of hydrophobic interactions and hydrogen bonding. In AChE, the indole moiety of both compounds interacted with the residues lining the peripheral anionic site, whereas in BChE, their methoxy groups are primarily responsible for the strong inhibitory activity via interactions with residues at the active site of the enzyme.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2321 mL 16.1603 mL 32.3206 mL 64.6412 mL 80.8016 mL
    5 mM 0.6464 mL 3.2321 mL 6.4641 mL 12.9282 mL 16.1603 mL
    10 mM 0.3232 mL 1.616 mL 3.2321 mL 6.4641 mL 8.0802 mL
    50 mM 0.0646 mL 0.3232 mL 0.6464 mL 1.2928 mL 1.616 mL
    100 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.6464 mL 0.808 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (+)-Affinisine; (+)-Affinisine CFN92612 2912-11-0 C20H24N2O = 308.4 5mg QQ客服:215959384
    马枯星碱B; Macusine B CFN96211 6792-07-0 C20H25N2O = 309.4 5mg QQ客服:215959384
    斯佩加春; Spegatrine CFN96170 47326-53-4 C20H25N2O2 = 325.4 10mg QQ客服:1413575084
    10-Hydroxy-16-epiaffinine; 10-Hydroxy-16-epiaffinine CFN96097 82513-70-0 C20H24N2O3 = 340.4 5mg QQ客服:2056216494
    佩立任碱; Pelirine CFN96181 30435-26-8 C21H26N2O3 = 354.5 5mg QQ客服:3257982914
    Taberpsychine; Taberpsychine CFN96148 19452-84-7 C20H24N2O = 308.4 5mg QQ客服:2056216494
    N-Methoxyanhydrovobasinediol; N-Methoxyanhydrovobasinediol CFN97989 125180-42-9 C21H26N2O2 = 338.5 5mg QQ客服:2159513211
    16-表伏康树卡平碱; 16-Epivoacarpine CFN96030 114027-38-2 C21H24N2O4 = 368.4 5mg QQ客服:215959384
    16-表-NB-甲基伏康树卡平碱; Gelsempervine A CFN96018 865187-17-3 C22H26N2O4 = 382.5 5mg QQ客服:3257982914
    16-表降马枯星碱B; 16-Epinormacusine B CFN96130 126640-98-0 C19H22N2O = 294.4 5mg QQ客服:2159513211

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