石吊兰甲素

Lysionotin

	产品编号	CFN99787
	CAS编号	152743-19-6
	分子式 = 分子量	C₁₈H₁₆O₇ = 344.32
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The herbs of Lysionotus pauciflorus Maxim.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
石吊兰甲素	CFN99787	152743-19-6	10mg	QQ客服：2056216494
石吊兰甲素	CFN99787	152743-19-6	20mg	QQ客服：2056216494
石吊兰甲素	CFN99787	152743-19-6	50mg	QQ客服：2056216494
石吊兰甲素	CFN99787	152743-19-6	100mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Nanjing University of Chinese Medicine (China)

Universita' Degli Studi Di Cagliari (Italy)

Sanford Burnham Medical Research Institute (USA)

Sapienza University of Rome (Italy)

Ateneo de Manila University (Philippines)

National Research Council of Canada (Canada)

Universidad de Ciencias y Artes de Chiapas (Mexico)

Agricultural Research Organization (ARO) (Israel)

Universidade Católica Portuguesa (Portugal)

Washington State University (USA)

Universidad Miguel Hernández (Spain)

University of Canterbury (New Zealand)

Mahatma Gandhi University (India)

Rio de Janeiro State University (Brazil)

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Description:

Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities. It is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo.

In vitro:

Appl Microbiol Biotechnol. 2017 Sep;101(17):6697-6703.

Lysionotin attenuates Staphylococcus aureus pathogenicity by inhibiting α-toxin expression.[Pubmed: 28710557 ]

α-Toxin, one of the best known pore-forming proteins produced by Staphylococcus aureus (S. aureus), is a critical virulence factor in multiple infections. The necessity of α-toxin for S. aureus pathogenicity suggests that this toxin is an important target for the development of a potential treatment strategy.
METHODS AND RESULTS:
In this study, we showed that lysionotin, a natural compound, can inhibit the hemolytic activity of culture supernatants by S. aureus by reducing α-toxin expression. Using real-time PCR analysis, we showed that transcription of hla (the gene encoding α-toxin) and agr (the locus regulating hla) was significantly inhibited by lysionotin. Lactate dehydrogenase and live/dead assays indicated that lysionotin effectively protected human alveolar epithelial cells against S. aureus, and in vivo studies also demonstrated that lysionotin can protect mice from pneumonia caused by S. aureus. These findings suggest that lysionotin is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo.
CONCLUSIONS:
This study supports a potential strategy for the treatment of S. aureus infection by inhibiting the expression of virulence factors and indicates that lysionotin may be a potential treatment for S. aureus pneumonia.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin	CFN98843	520-36-5	C₁₅H₁₀O₅ = 270.2	20mg	QQ客服：1457312923
芫花素; Genkwanin	CFN98670	437-64-9	C₁₆H₁₂O₅ = 284.3	20mg	QQ客服：1457312923
黄花夹竹桃黄酮; Thevetiaflavone	CFN96124	29376-68-9	C₁₆H₁₂O₅ = 284.3	5mg	QQ客服：3257982914
野黄芩素; Scutellarein	CFN98557	529-53-3	C₁₅H₁₀O₆ = 286.24	20mg	QQ客服：3257982914
高车前素; Hispidulin	CFN99491	1447-88-7	C₁₆H₁₂O₆ = 300.3	20mg	QQ客服：1413575084
蓟黄素; Cirsimaritin	CFN97126	6601-62-3	C₁₇H₁₄O₆ = 314.3	10mg	QQ客服：1457312923
8-羟基芹菜素; Isoscutellarein	CFN91491	41440-05-5	C₁₅H₁₀O₆ = 286.2	5mg	QQ客服：2056216494
4'-羟基汉黄芩素; 4'-Hydroxywogonin	CFN98960	57096-02-3	C₁₆H₁₂O₆ = 300.3	10mg	QQ客服：3257982914
5,8-二羟基-2-(4-羟基苯基)-6,7-二甲氧基-4H- 1-苯并吡喃-4-酮; Isothymusin	CFN97562	98755-25-0	C₁₇H₁₄O₇ = 330.3	5mg	QQ客服：1457312923
金合欢素；刺槐素; Acacetin	CFN98744	480-44-4	C₁₆H₁₂O₅ = 284.3	20mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9043 mL	14.5214 mL	29.0428 mL	58.0855 mL	72.6069 mL
5 mM	0.5809 mL	2.9043 mL	5.8086 mL	11.6171 mL	14.5214 mL
10 mM	0.2904 mL	1.4521 mL	2.9043 mL	5.8086 mL	7.2607 mL
50 mM	0.0581 mL	0.2904 mL	0.5809 mL	1.1617 mL	1.4521 mL
100 mM	0.029 mL	0.1452 mL	0.2904 mL	0.5809 mL	0.7261 mL