欧当归内酯A
Levistilide A
|
|
产品编号 |
CFN99707 |
| CAS编号 |
88182-33-6 |
| 分子式 = 分子量 |
C24H28O4 = 380.48 |
| 产品纯度 |
>=98% |
| 物理属性 |
Solid |
| 化合物类型 |
Miscellaneous |
| 植物来源 |
The roots of Angelica sinensis |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 欧当归内酯A |
CFN99707 |
88182-33-6 |
10mg |
QQ客服：3257982914 |
| 欧当归内酯A |
CFN99707 |
88182-33-6 |
20mg |
QQ客服：3257982914 |
| 欧当归内酯A |
CFN99707 |
88182-33-6 |
50mg |
QQ客服：3257982914 |
| 欧当归内酯A |
CFN99707 |
88182-33-6 |
100mg |
QQ客服：3257982914 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
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Korea Institute of Oriental Medicine (Korea)
Universidade Federal de Goias (UFG) (Brazil)
Seoul National University (Korea)
Institute of Pathophysiology Medical University of Vienna (Austria)
Research Unit Molecular Epigenetics (MEG) (Germany)
Sanford Burnham Prebys Medical Discovery Institute (USA)
University of Sao Paulo (Brazil)
Mahidol University (Thailand)
Almansora University (Egypt)
University of British Columbia (Canada)
National Research Council of Canada (Canada)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Periyar University (India)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Traditional formula compatibility of Danggui-Shaoyao-San could significantly enhance levistilide A bioavailability compared with levistilide A alone and Rhizoma Chuanxiong. |
| In vitro: |
| Cell Physiol Biochem . 2017;42(3):929-938. | | Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells[Pubmed: 28662507] | | Abstract
Background/aims: Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. In this study, we investigated the anticancer effect of LA in HCT116 and its isogenic p53-/- colon cancer cells, as well as the underlying mechanisms.
Methods: MTT assay was used to evaluate the effect of LA on the viability of cancer cells. Apoptosis and reactive oxygen species (ROS) production by the cells were determined by flow cytometry. Protein expression was detected by western blotting.
Results: The results showed that LA inhibited viability and caused apoptosis of both wild-type and p53-/- HCT116 cells. LA was able to trigger production of ROS and endoplasmic reticulum (ER) stress. Inhibition of ROS using N-acetylcysteine abrogated LA-induced ER stress and apoptosis, as well as the reduction in cancer cell viability.
Conclusion: Our results indicate that LA causes apoptosis of colon cancer cells via ROS-mediated ER stress pathway. It will be interesting to develop the natural compound for chemotherapy of cancers such as CRC.
Keywords: Apoptosis; ER stress; Levistolide A; ROS. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.6283 mL |
13.1413 mL |
26.2826 mL |
52.5652 mL |
65.7065 mL |
| 5 mM |
0.5257 mL |
2.6283 mL |
5.2565 mL |
10.513 mL |
13.1413 mL |
| 10 mM |
0.2628 mL |
1.3141 mL |
2.6283 mL |
5.2565 mL |
6.5706 mL |
| 50 mM |
0.0526 mL |
0.2628 mL |
0.5257 mL |
1.0513 mL |
1.3141 mL |
| 100 mM |
0.0263 mL |
0.1314 mL |
0.2628 mL |
0.5257 mL |
0.6571 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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