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  • Latifolin

    Latifolin

    Latifolin
    产品编号 CFN89503
    CAS编号 10154-42-4
    分子式 = 分子量 C17H18O4 = 286.32
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The heartwood of Dalbergia odorifera T. Chen.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Latifolin CFN89503 10154-42-4 1mg QQ客服:2056216494
    Latifolin CFN89503 10154-42-4 5mg QQ客服:2056216494
    Latifolin CFN89503 10154-42-4 10mg QQ客服:2056216494
    Latifolin CFN89503 10154-42-4 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Osmania University (India)
  • Universitas Airlangga (Indonesia)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Charles University in Prague (Czech Republic)
  • Istanbul University (Turkey)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Instituto Politécnico de Bragan?a (Portugal)
  • National Cancer Center Research Institute (Japan)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Universite Libre de Bruxelles (Belgium)
  • University of Fribourg (Switzerland)
  • Calcutta University (India)
  • Sant Gadge Baba Amravati University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Forensic Sci Int.2022, 341:111475.
  • Phytother Res.2022, 10.1002:ptr.7592.
  • ACS Chem Biol.2019, 14(5):873-881
  • Front Immunol.2018, 9:2091
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • World J Mens Health.2019, 10.5534
  • Arch Pharm Res.2015, 38(6):1080-9
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Int J Anal Chem.2017, 2017:1254721
  • Toxicol In Vitro.2023, 86:105521.
  • Industrial Crops and Products2019, 140:111612
  • J Chromatogr A.2017, 1518:46-58
  • Phytomedicine.2019, 61:152813
  • Metabolites.2020, 11(1):E11.
  • Molecules.2022, 27(7):2093.
  • Genes (Basel).2021, 12(7):1024.
  • Korean J Acupunct2020, 37:104-121
  • Journal of Chromatography A2020, 460942
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • J Ethnopharmacol.2019, 241:112025
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Integr Cancer Ther.2018, 17(3):832-843
  • J Biomol Struct Dyn.2022, 5;1-17.
  • ...
  • 生物活性
    Description: Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays potent anticarcinogenic phase II marker enzyme, quinone reductase (QR) inducing activity and high chemopreventive indices. Latifolin also shows antifungal activity against white- and brown-rot fungi.
    Targets: HO-1 | NF-kB | COX | NO | PGE | TNF-α | IL Receptor | Nrf2 | IkB | NOS | Antifection | IKK
    In vitro:
    J Agric Food Chem. 2009 Jul 8;57(13):5707-12.
    Bioactivity of latifolin and its derivatives against termites and fungi.[Pubmed: 19499920]

    METHODS AND RESULTS:
    Latifolin (1) and its derivatives were investigated with the aim of confirming the correlation between bioactivity (antitermite and antifungal activity) and chemical structure. Termite mortality in response to the derivatives 2'-O-methylLatifolin (2), Latifolin dimethyl ether (4), and Latifolin diacetate (5) increased 2-fold compared to compound 1. The mortality rate from 5-O-methylLatifolin (3) was not different from 1. The mass loss (feed consumption by termite) in response to compounds 3-5 was 3 times greater than compound 1, and the mass loss from compound 2 was twice as great as compound 1. The mortality rate from compounds 4 and 5 increased sharply 7 days after initial exposure. In assessing the antifungal activity of these compounds, it was found that the inhibition rates of white- and brown-rot fungi in response to all derivatives were less than that for compound 1.
    CONCLUSIONS:
    Our findings indicate that the phenolic hydroxyl group at C-5 of the A ring provides antitermite activities (mortality and mass loss). In addition, both C-5 and C-2' phenolic hydroxyl groups in the A and B rings have antifungal activity against white- and brown-rot fungi. In conclusion, the bioactivity of compound 1 depends upon the position of phenolic hydroxyl groups.
    Arch Pharm Res. 2004 Sep;27(9):919-22.
    Induction of the anticarcinogenic marker enzyme, quinone reductase, by Dalbergiae Lignum.[Pubmed: 15473661]

    METHODS AND RESULTS:
    The effect of an extract of Dalbergiae Lignum and four components that were isolated from the extract on the anticarcinogenic phase II marker enzyme, quinone reductase (QR), was investigated. Of the solvent extracts of Dalbergiae Lignum, the CH2Cl2 fraction was the most potent in inducing QR activity, with a CD value (the concentration required to double the QR activity) of 29.5 microg/mL. The CH2Cl2 extract was further separated into six compounds, four of which were identified as 4-methoxydalbergione, latifolin, 4',6-dihydroxy-7-methoxyflavanone, and obtusafuran. Obtusafuran [CD = 1.1 microM; chemopreventive index (CI) = 101.9] and latifolin (CD = 1.7 microM; CI = 154.6) displayed potent QR inducing activity and high chemopreventive indices.
    CONCLUSIONS:
    Latifolin and 4-methoxydalbergione were identified as strong DPPH-scavengers with half-maximal free radical scavenging concentrations of 15.9 and 17.2 microM, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4926 mL 17.463 mL 34.926 mL 69.8519 mL 87.3149 mL
    5 mM 0.6985 mL 3.4926 mL 6.9852 mL 13.9704 mL 17.463 mL
    10 mM 0.3493 mL 1.7463 mL 3.4926 mL 6.9852 mL 8.7315 mL
    50 mM 0.0699 mL 0.3493 mL 0.6985 mL 1.397 mL 1.7463 mL
    100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6985 mL 0.8731 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Dalbergiphenol; Dalbergiphenol CFN89160 52811-31-1 C17H18O3 = 270.32 5mg QQ客服:2159513211
    5-O-Methyldalbergiphenol; 5-O-Methyldalbergiphenol CFN89532 1499946-35-8 C18H20O3 = 284.34 5mg QQ客服:2056216494
    Latifolin; Latifolin CFN89503 10154-42-4 C17H18O4 = 286.32 5mg QQ客服:2056216494
    3'-Hydroxy-2,4,5-trimethoxydalbergiquinol; 3'-Hydroxy-2,4,5-trimethoxydalbergiquinol CFN95410 N/A C18H20O4 = 300.4 5mg QQ客服:1413575084

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