| In vitro: |
| Nat Prod Res. 2016 Sep;30(17):1984-7. | | Antimicrobial compounds from root, stem bark and seeds of Melia volkensii.[Pubmed: 26517430] | Three compounds, toosendanin (1), Kulactone (2) and scopoletin (3), were isolated from either the root bark and/or the stem bark of Melia volkensii. Their structures were determined on the basis of spectroscopic data generated and by comparison with data from the literature.
METHODS AND RESULTS:
1 and 2, isolated for the first time from M. volkensii, exhibited significant (p < 0.05) activity against Escherichia coli with minimum inhibitory concentration of 12.5 μg/mL, close to that of neomycin (6.25 μg/mL). The compounds also exhibited high activity against Aspergillus niger (MIC 6.25 μg/mL compared to 2.5 μg/mL for clotrimazole). Dichloromethane and methanol seed, hexane stem bark and methanol root bark extracts exhibited activities towards Escherichia coli, Staphylococcus aureus, Aspergillus niger and Plasmodium falciparum, respectively.
CONCLUSIONS:
Antimicrobial activity of the plant towards A. niger, P. falciparum and S. aureus is reported for the first time in the current work. |
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