Kuguacin J

	产品编号	CFN92073
	CAS编号	1141453-65-7
	分子式 = 分子量	C₃₀H₄₆O₃ = 454.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The fruits of Momordica charantia
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Kuguacin J	CFN92073	1141453-65-7	1mg	QQ客服：1457312923
Kuguacin J	CFN92073	1141453-65-7	5mg	QQ客服：1457312923
Kuguacin J	CFN92073	1141453-65-7	10mg	QQ客服：1457312923
Kuguacin J	CFN92073	1141453-65-7	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Shanghai Institute of Organic Chemistry (China)

Monash University Malaysia (Malaysia)

Celltrion Chemical Research Institute (Korea)

Hamdard University (India)

Nicolaus Copernicus Uniwersity (Poland)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

University of Leipzig (Germany)

Ain Shams University (Egypt)

University of Fribourg (Switzerland)

Wroclaw Medical University (Poland)

Medical University of South Carolina (USA)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

University of British Columbia (Canada)

Srinakharinwirot University (Thailand)

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Description:

Kuguacin J is a promising candidate new antineoplastic and chemopreventive agent for androgen-dependent prostate cancer and carcinogenesis, it exerts growth inhibition through G1 arrest and induction of apoptosis in androgen-dependent human prostate cancer. Kuguacin J modulates the function of P-glycoprotein (P-gp) by directly interacting at the drug-substrate-binding site, and it appears to be an effective inhibitor of P-gp activity in vitro and thus could be developed as an effective chemosensitizer to treat multidrug-resistant cancers.

Targets:

p21 | CDK | Bcl-2/Bax | Caspase | PARP | Androgen Receptor | p53 | P-gp

In vitro:

Cancer Lett., 2011, 306(2):142-50.

Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf.[Pubmed: 21429659 ]

In this study, we focused on the effects of a bitter melon (Momordica charantia) leaf extract (BMLE) and a purified component, Kuguacin J (KuJ), on androgen-dependent LNCaP human prostate cancer cells.
METHODS AND RESULTS:
Both treatments exerted growth inhibition through G1 arrest and induction of apoptosis. In addition, KuJ markedly decreased the levels of cyclins (D1 and E), cyclin-dependent kinases (Cdk2 and Cdk4) and proliferating cell nuclear antigen, and caused an increase in p21 and p27 levels. Its induction of apoptosis was accompanied by an increase in cleavage of caspase-3 and poly (ADP-ribose) polymerase, attributable to augment of Bax/Bcl-2 and Bad/Bcl-xL and reduction of survivin levels. BMLE and KuJ also reduced the expression of androgen receptor (AR), prostate-specific antigen (PSA) while induced P53 protein level. Down-regulation of p53 by RNA interference indicated that BMLE and KuJ inhibited cell growth partly through p53-dependent cell cycle arrest and apoptotic pathways. Both BMLE and KuJ caused less toxicity in a normal prostate cell line, PNT1A.
CONCLUSIONS:
Our results suggest that BMLE and a purified component, KuJ, from its diethyl ether fraction could be promising candidate new antineoplastic and chemopreventive agents for androgen-dependent prostate cancer and carcinogenesis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
24-羟基苦瓜素III; 24-Hydroxymomordicine III	CFN95169	N/A	C₃₆H₅₈O₁₀ = 650.9	5mg	QQ客服：1457312923
Kuguacin J; Kuguacin J	CFN92073	1141453-65-7	C₃₀H₄₆O₃ = 454.7	5mg	QQ客服：215959384
苦瓜皂苷 C; Kuguaglycoside C	CFN92309	1041631-93-9	C₃₆H₅₆O₈ = 616.8	5mg	QQ客服：1457312923
苦瓜素 I; Momordicine I	CFN92076	91590-76-0	C₃₀H₄₈O₄ = 472.7	10mg	QQ客服：1413575084
苦瓜素II; Momordicine II	CFN95167	91590-75-9	C₃₆H₅₈O₉ = 634.9	10mg	QQ客服：1457312923
苦瓜素V; Momordicine V	CFN95164	1012315-36-4	C₃₉H₆₀O₁₂ = 720.9	5mg	QQ客服：3257982914
Kuguacin N; Kuguacin N	CFN92074	1141453-73-7	C₃₀H₄₆O₄ = 470.7	5mg	QQ客服：1457312923
3β,7β,25-三羟基-葫芦烷-5,(23E)-双稀-19-醛; 3,7,25-Trihydroxycucurbita-5,23-dien-19-al	CFN95150	85372-65-2	C₃₀H₄₈O₄ = 472.7	5mg	QQ客服：2159513211
苦瓜皂苷 L; Momordicoside L	CFN92307	81348-83-6	C₃₆H₅₈O₉ = 634.9	5mg	QQ客服：2159513211
苦瓜皂苷 X; Momordicoside X	CFN95170	1333321-50-8	C₃₆H₅₈O₉ = 634.9	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1993 mL	10.9963 mL	21.9925 mL	43.985 mL	54.9813 mL
5 mM	0.4399 mL	2.1993 mL	4.3985 mL	8.797 mL	10.9963 mL
10 mM	0.2199 mL	1.0996 mL	2.1993 mL	4.3985 mL	5.4981 mL
50 mM	0.044 mL	0.2199 mL	0.4399 mL	0.8797 mL	1.0996 mL
100 mM	0.022 mL	0.11 mL	0.2199 mL	0.4399 mL	0.5498 mL