尾叶香茶菜丙素

Kamebakaurin

	产品编号	CFN91932
	CAS编号	73981-34-7
	分子式 = 分子量	C₂₀H₃₀O₅ = 350.45
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The herbs of Rabdosia serra
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
尾叶香茶菜丙素	CFN91932	73981-34-7	1mg	QQ客服：1457312923
尾叶香茶菜丙素	CFN91932	73981-34-7	5mg	QQ客服：1457312923
尾叶香茶菜丙素	CFN91932	73981-34-7	10mg	QQ客服：1457312923
尾叶香茶菜丙素	CFN91932	73981-34-7	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sanford Burnham Medical Research Institute (USA)

Imperial College London (United Kingdom)

Griffith University (Australia)

Centralised Purchases Unit (CPU), B.I.T.S (India)

Anna University (India)

Mahidol University (Thailand)

Universitas Airlangga (Indonesia)

University of Bonn (Germany)

University of Queensland (Australia)

National Cancer Center Research Institute (Japan)

Universiti Malaysia Pahang (Malaysia)

Universidad de Antioquia (Colombia)

Calcutta University (India)

Universidad de Buenos Aires (Argentina)

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Description:

Kamebakaurin has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50; it has anti-neuroinflammatory activity via inhibition of c-Jun NH₂-terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells. Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity. Kamebakaurin also has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress.

Targets:

HIF | Topoisomerase | VEGFR | NF-kB | JNK | p38MAPK | IkB | NO | COX | NOS | IKK

In vitro:

J Pharmacol Sci. 2011;116(3):296-308.

Anti-neuroinflammatory activity of Kamebakaurin from Isodon japonicus via inhibition of c-Jun NH₂-terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells.[Pubmed: 21705843]

Compelling evidence supports the notion that the majority of neurodegenerative diseases are associated with microglia-mediated neuroinflammation. Therefore, quelling of microglial activation may lead to neuronal cell survival.
METHODS AND RESULTS:
The present study investigated the effects of Kamebakaurin (KMBK), a kaurane diterpene isolated from Isodon japonicus HARA (Labiatae), on the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated cytotoxicity in rat primary microglial cultures and the BV-2 cell line. KMBK significantly inhibited the LPS-induced production of nitric oxide (NO) in a concentration-dependent fashion in activated microglial cells. The mRNA and protein levels of inducible nitric oxide synthase (iNOS) and cyclooxycenase-2 (COX-2) were also decreased dose-dependently. Furthermore KMBK inhibited the JNK and p38 mitogen-activated protein kinases (MAPKs) in LPS-stimulated BV-2 microglial cells.
CONCLUSIONS:
Considering the results obtained, the present study authenticated the potential benefits of KMBK as a therapeutic target in ameliorating microglia-mediated neuroinflammatory diseases.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
疏展香茶菜宁A; Effusanin A	CFN98377	30220-43-0	C₂₀H₂₈O₅ = 348.4	5mg	QQ客服：1413575084
疏展香茶菜宁B; Effusanin B	CFN92434	76470-16-1	C₂₂H₃₀O₆ = 390.5	5mg	QQ客服：2159513211
Lasiodin; Lasiodin	CFN92430	28957-08-6	C₂₂H₃₀O₇ = 406.5	5mg	QQ客服：2159513211
长管贝壳杉素E; Longikaurin E	CFN97266	77949-42-9	C₂₂H₃₀O₆ = 390.5	5mg	QQ客服：3257982914
疏展香茶菜宁E; Effusanin E	CFN92262	76470-15-0	C₂₀H₂₈O₆ = 364.4	5mg	QQ客服：1413575084
Taibaihenryiins A; Taibaihenryiins A	CFN92314	398129-59-4	C₂₂H₃₀O₇ = 406.5	5mg	QQ客服：3257982914
希柯勘宁; Shikokianin	CFN92311	24267-69-4	C₂₄H₃₂O₈ = 448.5	5mg	QQ客服：2056216494
旱生香茶菜素G; Xerophilusin G	CFN98386	304642-94-2	C₂₂H₃₀O₈ = 422.5	5mg	QQ客服：1457312923
Trichokaurin; Trichokaurin	CFN97984	23811-50-9	C₂₄H₃₄O₇ = 434.5	5mg	QQ客服：1413575084
毛叶香茶菜素; Maoyerabdosin	CFN96034	90468-72-7	C₂₄H₃₆O₉ = 468.5	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8535 mL	14.2674 mL	28.5347 mL	57.0695 mL	71.3369 mL
5 mM	0.5707 mL	2.8535 mL	5.7069 mL	11.4139 mL	14.2674 mL
10 mM	0.2853 mL	1.4267 mL	2.8535 mL	5.7069 mL	7.1337 mL
50 mM	0.0571 mL	0.2853 mL	0.5707 mL	1.1414 mL	1.4267 mL
100 mM	0.0285 mL	0.1427 mL	0.2853 mL	0.5707 mL	0.7134 mL