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  • 山奈酚葡萄糖醛酸苷

    • 山奈酚葡萄糖醛酸苷

    Kaempferol-3-beta-O-glucuronide

    山奈酚葡萄糖醛酸苷
    		产品编号 CFN90359
    CAS编号 22688-78-4
    分子式 = 分子量 C21H18O12 = 462.36
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Euphorbia lathyris
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    山奈酚葡萄糖醛酸苷 CFN90359 22688-78-4 1mg QQ客服：3257982914
    山奈酚葡萄糖醛酸苷 CFN90359 22688-78-4 5mg QQ客服：3257982914
    山奈酚葡萄糖醛酸苷 CFN90359 22688-78-4 10mg QQ客服：3257982914
    山奈酚葡萄糖醛酸苷 CFN90359 22688-78-4 20mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Mendel University in Brno (Czech Republic)
  • Center for protein Engineering (CIP) (Belgium)
  • Celltrion Chemical Research Institute (Korea)
  • Tokyo Woman's Christian University (Japan)
  • Universidade Católica Portuguesa (Portugal)
  • VIT University (India)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Srinakharinwirot University (Thailand)
  • Sanford Burnham Medical Research Institute (USA)
  • Univerzita Karlova v Praze (Czech Republic)
  • Julius Kühn-Institut (Germany)
  • University of Toronto (Canada)
  • Michigan State University (USA)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2024, 456:140044.
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Pak J Pharm Sci.2019, 32(6)
  • Food Chem.2023, 427:136647.
  • Sci Rep.2018, 8(1):12970
  • Pathogens.2018, 7(3):E62
  • J Ethnopharmacol.2023, 313:116534.
  • Chemistry of Natural Compounds2018, 54(3):572-576
  • Molecules.2024, 29(22):5261.
  • Ulm University Medical Center2020, doi: 10.18725.
  • Acta horticulturae2017, 1158:257-268
  • Evid Based Complement Alternat Med.2021, 8855980.
  • J Cancer.2019, 10(23):5843-5851
  • Pharmaceuticals (Basel).2024, 17(4):442.
  • Int J Mol Sci.2023, 24(3):2102.
  • J Clin Med.2022, 11(13):3662.
  • Front Pharmacol.2021, 12:762829.
  • Int. J of Herbal Med.2023, 11(1): 06-14
  • J. Food Composition and Anal.2022, V 109:104482.
  • Biotechnol Bioeng.2020, 117(7):2198-2208.
  • Nutrients.2023, 15(6):1335.
  • J Agric Food Chem.2024, acs.jafc.4c01387.
  • Chulalongkorn University2024, 4761190
  • ...
    • 生物活性
    Description: Kaempferol-3-beta-O-glucuronide has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal β-glucuronidase from various human cells.
    In vitro:
    Z Naturforsch C. 2007 Sep-Oct;62(9-10):656-60.
    Evaluation of cytotoxic compounds from calligonum comosum L. growing in Egypt.[Pubmed: 18069236]

    METHODS AND RESULTS:
    Calligonum comosum (Polygonaceae), an Egyptian desert plant, was extracted and fractionated using petroleum ether, methylene chloride, and ethyl acetate. The total methanolic extract and other fractions were tested for their anticancer activity using Ehrlich ascites, brine shrimp and antioxidant assays. Ethyl acetate fraction proved to be the most active in all assays. Eight compounds were isolated, purified, and identified from this fraction as (+)-catechin (1), dehydrodicatechin A (2), kaempferol-3-O-rhamnopyranoside (3), quercitrin (quercetin-3-O-rhamnopyranoside) (4), beta-sitosterol-3-O-glucoside (5), isoquercitrin (quercetin-3-O-glucopyranoside) (6), kaempferol-3-O-glucuronide (Kaempferol-3-beta-O-glucuronide,7), and mequilianin (quercetin-3-O-glucuronide) (8).
    CONCLUSIONS:
    All isolated compounds were tested for their cytotoxicity and antioxidant activity. Compound 2 showed the best cytotoxic and antioxidant activity.
    In vivo:
    Int Immunopharmacol . 2018 Apr;57:62-71.
    Kaempferol-3-o-β-d-glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model[Pubmed: 29475097]
    Abstract Kaempferol-3-O-β-d-glucuronide (K3G) having various pharmacological effects was explored for its anti-inflammatory effect in LPS induced RAW 264.7 cells and mice model. K3G significantly inhibited various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. It upregulated the secretion of anti-inflammatory cytokine IL-10. K3G is found to reduce inflammation when studied for parameters like phagocytic index, carrageenan induced paw edema in mice and organ weight. It reduced inflammation in a dose dependent manner both in-vitro and in-vivo. Further molecular insights into the study reveal that K3G blocks the phosphorylation of NF-kB which is key regulator of inflammation, thereby exhibiting anti-inflammatory potential. Hence, this study permits further investigation to develop K3G as anti-inflammatory drug. Keywords: Anti-inflammatory; Histopathology; Pathway elucidation; Proinflammatory.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1628 mL 10.8141 mL 21.6282 mL 43.2563 mL 54.0704 mL
    5 mM 0.4326 mL 2.1628 mL 4.3256 mL 8.6513 mL 10.8141 mL
    10 mM 0.2163 mL 1.0814 mL 2.1628 mL 4.3256 mL 5.407 mL
    50 mM 0.0433 mL 0.2163 mL 0.4326 mL 0.8651 mL 1.0814 mL
    100 mM 0.0216 mL 0.1081 mL 0.2163 mL 0.4326 mL 0.5407 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2''-O-对香豆酰胡桃苷; 2''-O-Coumaroyljuglanin CFN96261 67214-05-5 C29H24O12 = 564.5 5mg QQ客服：2056216494
    堪非醇3-O-阿拉伯糖苷; Kaempferol 3-O-arabinoside CFN97572 99882-10-7 C20H18O10 = 418.4 5mg QQ客服：2056216494
    阿福豆苷; Afzelin CFN98757 482-39-3 C21H20O10 = 432.4 20mg QQ客服：2056216494
    2'',4''-二-O-(E-对香豆酰)阿福豆甙; 2'',4''-Di-O-(E-p-coumaroyl)afzelin CFN96246 163434-73-9 C39H32O14 = 724.7 5mg QQ客服：2159513211
    2'',4''-二-O-(Z-对香豆酰)阿福豆甙; 2'',4''-Di-O-(Z-p-coumaroyl)afzelin CFN97788 205534-17-4 C39H32O14 = 724.68 5mg QQ客服：1413575084
    山奈酚3-O-半乳糖苷; Kaempferol-3-O-galactoside CFN92079 23627-87-4 C21H20O11 = 448.4 10mg QQ客服：2159513211
    山奈酚葡萄糖醛酸苷; Kaempferol-3-beta-O-glucuronide CFN90359 22688-78-4 C21H18O12 = 462.36 5mg QQ客服：2159513211
    紫云英苷; Astragalin CFN98733 480-10-4 C21H20O11 = 448.4 20mg QQ客服：3257982914
    堪非醇3-O-(6''-O-乙酰基)葡萄糖甙; 6''-O-Acetylastragalin CFN99281 118169-27-0 C23H22O12 = 490.4 5mg QQ客服：3257982914
    2''-乙酰基黄芪苷; 2''-Acetylastragalin CFN97940 1206734-95-3 C23H22O12 = 490.4 5mg QQ客服：3257982914

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