| In vitro: |
| Chinese Traditional & Herbal Drugs, 2016, 47(11): 1830-3. | | Chemical constituents from whole plants of oehmannia chingii[Reference: WebLink] | To investigate the chemical constituents of Rehmannia chingii.
METHODS AND RESULTS:
The compounds were isolated from an aqueous extract from the whole plants of R.chingii by a combination of various chromatographic techniques including column chromatography over silica gel and Sephadex LH-20 and reversed-phase HPLC.Their structures were identified by spectroscopic analysis including MS and NMR data.
Seventeen compounds were isolated and identified as 8-methyloctahydrocyclopenta [c] pyran-1,3,6,8-tetraol(1),3,4-dihydroxy-phenethyl alcohol(2),3-methoxyl-4-hydroxyphenyl alcohol(3),phenylethyl-8-O-β-D-glucopyranoside(4),3,4-dihydroxy-β-phenethyl-O-α-L-rhamnopyranosyl-(1→3)-O-β-D-glucopyranoside(5),2-phenylethylO-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside(6),deacyl-martynoside(7),acteoside(8),isoacteoside(9),martynoside(10),isomartynoside(11),jionoside C(12),jionoside A1(13),Jionoside B1(14),3,4-dihydroxy-β-phenethyl-O-α-L-rhamnopyranosyl-(1→3)-O-β-D-galacopyranosyl-(1→6)-4-O-caffeoyl-β-D-glucopyranoside(15),cistanoside F(16),and isocistanoside F(17).
CONCLUSIONS:
Among the isolated seventeen compounds,compound 1 is a new compound named rehmachinin,and compounds 16-17 are isolated from the plants of Rehmannia Libosch.ex Fisch.et Mey.for the first time.
In the preliminary assays,compounds 9,12,and 14-16 exhibit the obvious inhibition against aldose reductase. |
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