夾可鹼

Jacobine

	产品编号	CFN00375
	CAS编号	6870-67-3
	分子式 = 分子量	C₁₈H₂₅NO₆ = 351.40
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Senecio scandens
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
夾可鹼	CFN00375	6870-67-3	1mg	QQ客服：3257982914
夾可鹼	CFN00375	6870-67-3	5mg	QQ客服：3257982914
夾可鹼	CFN00375	6870-67-3	10mg	QQ客服：3257982914
夾可鹼	CFN00375	6870-67-3	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

FORTH-IMBB (Greece)

Kazusa DNA Research Institute (Japan)

Siksha O Anusandhan University (India)

Nicolaus Copernicus Uniwersity (Poland)

Stanford University (USA)

University of Vigo (Spain)

Medical University of South Carolina (USA)

University of Auckland (New Zealand)

Korea Food Research Institute(KFRI) (Korea)

University of Wuerzburg (Germany)

Kyushu University (Japan)

Calcutta University (India)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Chiang Mai University (Thailand)

More...

Description:

Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. It was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments.

In vitro:

Biochemical and Biophysical Research Communications,1994,198(2):516–522.

Glutathione Conjugation with the Pyrrolizidine Alkaloid, Jacobine[Reference: WebLink]

METHODS AND RESULTS:
The reaction of glutathione with the epoxide containing pyrrolizidine alkaloid, jacobine, was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments; the rate of the reaction in the presence of rat hepatic glutathione-S-transferases did not differ from the non-enzymatic rate. Using ion-pairing liquid chromatography we were able to isolate the conjugate and obtain a daughter ion spectrum using Fast Atom Bombardment Mass Spectrometry together with Collisionally Activated Dissociation/Mass Analyzed Kinetic Energy experiments.

In vivo:

Toxicology Letters.1986,32(3):275-281.

Genotoxicity of the pyrrolizidine alkaloid jacobine in rats[Reference: WebLink]

Jacobine (JAC) is a pyrolizidine alkaloid (PA) exhibiting adverse hepatic effects similar to those induced by another PA, monocrotaline (MCT). The in vitro reaction kinetics of JAC, however, have been reported to differ quantitively from those of MCT.
METHODS AND RESULTS:
We report results of experiments to detect and characterize hepatic DNA damage resulting from in vivo administration of JAC (5–60 mg/kg i.p.) to male Sprague-Dawley rats. Hepatic nuclei were isolated and served as the source of DNA in these experiments. Alkaline elution was employed to characterize the type(s) of DNA damage induced. At 4 h post administration, JAC induced significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. Significant DNA-protein cross-linking was also induced by doses of 15–60 mg/kg. No DNA single-strand breaks were detected. Previous studies in this laboratory have shown MCT to induce these same types of lesions.
CONCLUSIONS:
Results from these experiments demonstrate that despite a reported difference in in vitro reaction kinetics, these compounds induce a similar spectrum of DNA damage in the target organ of a susceptible species, where the adverse effects induced are also similar, such similarities are consistent with the involvement of DNA damage in the adverse hepatic effects of PAs.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
马杜拉猪屎豆碱; Madurensine	CFN00380	26126-78-3	C₁₈H₂₅NO₆ = 351.40	5mg	QQ客服：215959384
Spiranine; Spiranine	CFN00382	77156-23-1	C₂₃H₃₅NO₉ = 469.53	5mg	QQ客服：2159513211
野百合碱N-氧化物; Monocrotaline N-oxide	CFN00385	35337-98-5	C₁₆H₂₃NO₇ = 341.36	5mg	QQ客服：215959384
美丽猪屎豆碱; Spectabiline	CFN00386	520-55-8	C₁₈H₂₅NO₇ = 367.40	5mg	QQ客服：3257982914
Parsonsine; Parsonsine	CFN00399	72213-98-0	C₂₂H₃₃NO₈ = 439.50	5mg	QQ客服：3257982914
Spiraline; Spiraline	CFN00400	77156-25-3	C₂₂H₃₃NO₉ = 455.50	5mg	QQ客服：2056216494
Seneciocannabine; Seneciocannabine	CFN00416	81855-31-4	C₁₈H₂₃NO₇ = 365.38	5mg	QQ客服：2159513211
Swazine; Swazine	CFN00431	38763-74-5	C₁₈H₂₃NO₆ = 349.38	5mg	QQ客服：2159513211
抗菌素 PF 1018; Antibiotic PF 1018	CFN00437	131256-42-3	C₂₈H₃₅NO₃ = 433.59	5mg	QQ客服：2056216494
Crosemperine; Crosemperine	CFN00362	30785-56-9	C₁₉H₂₉NO₆ = 367.44	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8458 mL	14.2288 mL	28.4576 mL	56.9152 mL	71.144 mL
5 mM	0.5692 mL	2.8458 mL	5.6915 mL	11.383 mL	14.2288 mL
10 mM	0.2846 mL	1.4229 mL	2.8458 mL	5.6915 mL	7.1144 mL
50 mM	0.0569 mL	0.2846 mL	0.5692 mL	1.1383 mL	1.4229 mL
100 mM	0.0285 mL	0.1423 mL	0.2846 mL	0.5692 mL	0.7114 mL