夾可鹼
Jacobine
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 夾可鹼 |
CFN00375 |
6870-67-3 |
1mg |
QQ客服：215959384 |
| 夾可鹼 |
CFN00375 |
6870-67-3 |
5mg |
QQ客服：215959384 |
| 夾可鹼 |
CFN00375 |
6870-67-3 |
10mg |
QQ客服：215959384 |
| 夾可鹼 |
CFN00375 |
6870-67-3 |
20mg |
QQ客服：215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
University of Wollongong (Australia)
Wageningen University (Netherlands)
Centralised Purchases Unit (CPU), B.I.T.S (India)
University of Hull (United Kingdom)
Chulalongkorn University (Thailand)
Research Unit Molecular Epigenetics (MEG) (Germany)
Chiang Mai University (Thailand)
Lodz University of Technology (Poland)
Korea Intitute of Science and Technology (KIST) (Korea)
Complutense University of Madrid (Spain)
Aarhus University (Denmark)
Leibniz Institute of Plant Biochemistry (Germany)
Universidad Miguel Hernández (Spain)
Florida A&M University (USA)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. It was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments. |
| In vitro: |
| Biochemical and Biophysical Research Communications,1994,198(2):516–522. | | Glutathione Conjugation with the Pyrrolizidine Alkaloid, Jacobine[Reference: WebLink] |
METHODS AND RESULTS:
The reaction of glutathione with the epoxide containing pyrrolizidine alkaloid, jacobine, was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments; the rate of the reaction in the presence of rat hepatic glutathione-S-transferases did not differ from the non-enzymatic rate. Using ion-pairing liquid chromatography we were able to isolate the conjugate and obtain a daughter ion spectrum using Fast Atom Bombardment Mass Spectrometry together with Collisionally Activated Dissociation/Mass Analyzed Kinetic Energy experiments. |
|
| In vivo: |
| Toxicology Letters.1986,32(3):275-281. | | Genotoxicity of the pyrrolizidine alkaloid jacobine in rats[Reference: WebLink] | Jacobine (JAC) is a pyrolizidine alkaloid (PA) exhibiting adverse hepatic effects similar to those induced by another PA, monocrotaline (MCT). The in vitro reaction kinetics of JAC, however, have been reported to differ quantitively from those of MCT.
METHODS AND RESULTS:
We report results of experiments to detect and characterize hepatic DNA damage resulting from in vivo administration of JAC (5–60 mg/kg i.p.) to male Sprague-Dawley rats. Hepatic nuclei were isolated and served as the source of DNA in these experiments. Alkaline elution was employed to characterize the type(s) of DNA damage induced. At 4 h post administration, JAC induced significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. Significant DNA-protein cross-linking was also induced by doses of 15–60 mg/kg. No DNA single-strand breaks were detected. Previous studies in this laboratory have shown MCT to induce these same types of lesions.
CONCLUSIONS:
Results from these experiments demonstrate that despite a reported difference in in vitro reaction kinetics, these compounds induce a similar spectrum of DNA damage in the target organ of a susceptible species, where the adverse effects induced are also similar, such similarities are consistent with the involvement of DNA damage in the adverse hepatic effects of PAs. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.8458 mL |
14.2288 mL |
28.4576 mL |
56.9152 mL |
71.144 mL |
| 5 mM |
0.5692 mL |
2.8458 mL |
5.6915 mL |
11.383 mL |
14.2288 mL |
| 10 mM |
0.2846 mL |
1.4229 mL |
2.8458 mL |
5.6915 mL |
7.1144 mL |
| 50 mM |
0.0569 mL |
0.2846 mL |
0.5692 mL |
1.1383 mL |
1.4229 mL |
| 100 mM |
0.0285 mL |
0.1423 mL |
0.2846 mL |
0.5692 mL |
0.7114 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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