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  • 异莫里林醇

    Isomorellinol

    异莫里林醇
    产品编号 CFN92095
    CAS编号 149655-53-8
    分子式 = 分子量 C33H38O7 = 546.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The herbs of Garcinia hanburyi Hook. f.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异莫里林醇 CFN92095 149655-53-8 1mg QQ客服:2056216494
    异莫里林醇 CFN92095 149655-53-8 5mg QQ客服:2056216494
    异莫里林醇 CFN92095 149655-53-8 10mg QQ客服:2056216494
    异莫里林醇 CFN92095 149655-53-8 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Lodz (Poland)
  • Celltrion Chemical Research Institute (Korea)
  • University of Bonn (Germany)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Universiti Malaysia Pahang (Malaysia)
  • John Innes Centre (United Kingdom)
  • Colorado State University (USA)
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  • University of Eastern Finland (Finland)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • National Cancer Institute (USA)
  • Sri Ramachandra University (India)
  • Korea Institute of Oriental Medicine (Korea)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2023, 117:154929.
  • Int J Mol Sci.2021, 22(21):11447.
  • Molecules.2022, 27(7):2116.
  • Front Pharmacol.2021, 12:652860.
  • Forensic Sci Int.2022, 341:111475.
  • Food Analytical Methods2017, 10:3225-3234
  • Front Aging Neurosci.2019, 11:230
  • Life Sci.2022, 311(Pt A):121157.
  • Food Res Int.2020, 133:109130.
  • Applied Biological Chemistry2023, 66:85.
  • Toxicol Appl Pharmacol.2022, 434:115815.
  • Tumour Biol.2015, 36(12):9385-93
  • Appl. Sci.2020, 10(5),1713.
  • Vietnam J. Chem.2023, 61(3),308-317
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Korean J. of Food Sci. and Tech2016, 172-177
  • J of L. Chroma.&Related Tech2017, 252-258
  • Natural Product Communications2020, doi: 10.1177.
  • Biomedicines.2020, 8(11):486.
  • Natural Product Communications2021, 16(9):1-10.
  • Research Square2022, rs.3.rs-1948239
  • Int J Mol Sci.2022, 23(11):6172.
  • ...
  • 生物活性
    Description: Isomorellinol induces apoptosis in cholangiocarcinoma (CCA)cells which is mediated through a mitochondria-dependent signaling pathway.
    In vitro:
    World J Gastroenterol. 2010 May 14;16(18):2235-43.
    Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines.[Pubmed: 20458760 ]
    To investigate the growth inhibitory mechanism of four caged xanthones from Garcinia hanburyi in cholangiocarcinoma (CCA) KKU-100 and KKU-M156 cells.
    METHODS AND RESULTS:
    Four caged xanthones, selected on the basis of their anticancer potency and chemical structure diversities (i.e. isomorellin, Isomorellinol, forbesione and gambogic acid) were used in this study. Growth inhibition of these caged xanthones was determined using the sulforhodamine B assay. Induction of apoptosis was assessed by observing cell morphology, ethidium bromide and acridine orange staining and DNA fragmentation assay. Levels of apoptotic-related gene and protein expressions were determined by a real-time reverse transcriptase polymerase chain reaction and Western blotting analysis, respectively.
    CONCLUSIONS:
    Our findings for the first time demonstrate that four caged xanthones induce apoptosis in CCA cells which is mediated through a mitochondria-dependent signaling pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8292 mL 9.1458 mL 18.2916 mL 36.5831 mL 45.7289 mL
    5 mM 0.3658 mL 1.8292 mL 3.6583 mL 7.3166 mL 9.1458 mL
    10 mM 0.1829 mL 0.9146 mL 1.8292 mL 3.6583 mL 4.5729 mL
    50 mM 0.0366 mL 0.1829 mL 0.3658 mL 0.7317 mL 0.9146 mL
    100 mM 0.0183 mL 0.0915 mL 0.1829 mL 0.3658 mL 0.4573 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Deoxymorellin; Deoxymorellin CFN92087 1064-34-2 C33H38O6 = 530.7 5mg QQ客服:3257982914
    Gaudichaudic acid; Gaudichaudic acid CFN92091 887923-46-8 C33H38O8 = 562.7 5mg QQ客服:1413575084
    藤黄酸; Morellic acid CFN92093 5304-71-2 C33H36O8 = 560.7 20mg QQ客服:1457312923
    异桑藤黄酸; Isomorellic acid CFN92094 5262-69-1 C33H36O8 = 560.7 5mg QQ客服:1413575084
    新化合物16; New compound 16 CFN95465 N/A C34H38O9 = 590.7 5mg QQ客服:1413575084
    异莫里林醇; Isomorellinol CFN92095 149655-53-8 C33H38O7 = 546.7 5mg QQ客服:1413575084

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