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  • 异牛蒡酚A

    Isolappaol A

    异牛蒡酚A
    产品编号 CFN95224
    CAS编号 131400-96-9
    分子式 = 分子量 C30H32O9 = 536.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Gymnadenia conopsea
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异牛蒡酚A CFN95224 131400-96-9 1mg QQ客服:3257982914
    异牛蒡酚A CFN95224 131400-96-9 5mg QQ客服:3257982914
    异牛蒡酚A CFN95224 131400-96-9 10mg QQ客服:3257982914
    异牛蒡酚A CFN95224 131400-96-9 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Malaysia Pahang (Malaysia)
  • Universidade Federal de Santa Catarina (Brazil)
  • University of East Anglia (United Kingdom)
  • Utrecht University (Netherlands)
  • University of Perugia (Italy)
  • Monash University (Australia)
  • Universite de Lille1 (France)
  • Northeast Normal University Changchun (China)
  • Shanghai University of TCM (China)
  • Seoul National University (Korea)
  • Universidade de Franca (Brazil)
  • Julius Kühn-Institut (Germany)
  • Ain Shams University (Egypt)
  • University of Auckland (New Zealand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Eur J Pharm Sci.2016, 94:33-45
  • Preprints2021, doi:10.20944
  • Int J Pharmacol2020, 16:1-9
  • J Biol Chem.2021, 297(6):101362.
  • Scientific World Journal.2014, 2014:654193
  • Molecules.2020, 25(18),4089.
  • Molecules.2018, 23(12):E3103
  • Molecules.2021, 26(2):313.
  • Molecules.2019, 24(10):E1926
  • Food Chem.2020, 332:127412
  • The Korea Society of Pha.2014, 300-314
  • Industrial Food Engineering2015, 19(4):408-413
  • Cardiovasc Toxicol.2021, 21(11):947-963.
  • Front Microbiol.2020, 11:583594.
  • Oxid Med Cell Longev2019, 9056845:13
  • Journal of Plant Growth Regulation2022, 10705-2.
  • Food Res Int.2022, 157:111397.
  • J Chromatogr Sci.2015, 53(5):824-9
  • J Ethnopharmacol.2019, 241:112025
  • Phytomedicine.2018, 41:62-66
  • Microorganisms.2021, 9(12):2514.
  • Food Chem.2021, 360:130063.
  • Drug Chem Toxicol.2020, 1-12.
  • ...
  • 生物活性
    Description: Isolappaol A can up-regulate the expression of jnk-1, it may promote the Caenorhabditis elegans longevity and stress resistance through a JNK-1-DAF-16 cascade.
    Targets: JNK
    In vitro:
    Phytochemistry, 01 Jul 2015, 117:340-350.
    Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans.[Reference: WebLink]
    Arctium lappa is a well-known traditional medicinal plant in China (TCM) and Europe that has been used for thousands of years to treat arthritis, baldness or cancer. The plant produces lignans as secondary metabolites, which have a wide range of bioactivities. Yet, their antiaging potential has not been explored.
    METHODS AND RESULTS:
    In this study, we isolated six lignans from A. lappa seeds, namely arctigenin, matairesinol, arctiin, isolappaol A, lappaol A, lappaol C, and lappaol F. The antioxidant and antiaging properties of the isolated lignans were studied using Caenorhabditis elegans as a relevant animal model. All lignans at concentrations of 10 and 100 μM significantly extended the mean life span of C. elegans. The strongest effect was observed with matairesinol, which at a concentration of 100 μM extended the life span of worms by 25%. Additionally, we observed that five lignans are strong free radical-scavengers in vitro and in vivo and all lignans can improve survival of C. elegans under oxidative stress. Furthermore, the lignans can induce the nuclear translocation of the transcription factor DAF-16 and up-regulate its expression, suggesting that a possible underlying mechanism of the observed longevity-promoting activity of lignans depends on DAF-16 mediated signaling pathway.
    CONCLUSIONS:
    All lignans up-regulated the expression of jnk-1, indicating that lignans may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Our study reports new antiaging activities of lignans, which might be candidates for developing antiaging agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8636 mL 9.3179 mL 18.6359 mL 37.2717 mL 46.5896 mL
    5 mM 0.3727 mL 1.8636 mL 3.7272 mL 7.4543 mL 9.3179 mL
    10 mM 0.1864 mL 0.9318 mL 1.8636 mL 3.7272 mL 4.659 mL
    50 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.7454 mL 0.9318 mL
    100 mM 0.0186 mL 0.0932 mL 0.1864 mL 0.3727 mL 0.4659 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异牛蒡酚A; Isolappaol A CFN95224 131400-96-9 C30H32O9 = 536.6 10mg QQ客服:2932563308
    牛蒡酚B; Lappaol B CFN95242 62359-60-8 C31H34O9 = 550.6 10mg QQ客服:1148253675
    牛蒡酚C; Lappaol C CFN95068 64855-00-1 C30H34O10 = 554.6 10mg QQ客服:1148253675
    异牛蒡酚C; Isolappaol C CFN95225 929905-15-7 C30H34O10 = 554.6 10mg QQ客服:215959384
    牛蒡酚F; Lappaol F CFN95069 69394-17-8 C40H42O12 = 714.8 10mg QQ客服:2932563308
    (+)-罗汉松树脂酚 ; (+)-Matairesinol CFN96715 148409-36-3 C20H22O6 = 358.39 5mg QQ客服:215959384
    Isosalicifolin; Isosalicifolin CFN96234 156974-99-1 C20H20O6 = 356.4 5mg QQ客服:2159513211
    去甲络石甙元; Nortrachelogenin CFN98454 34444-37-6 C20H22O7 = 374.4 10mg QQ客服:2159513211
    荛花酚 ; (+)-Nortrachelogenin CFN96714 61521-74-2 C20H22O7 = 374.38 5mg QQ客服:2932563308
    (7R)-甲氧基-8-表-罗汉松树脂酚 ; (7R)-Methoxy-8-epi-matairesinol CFN89300 198827-23-5 C21H24O7 = 388.41 5mg QQ客服:1413575084

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