匙羹藤酸I

Gymnemic acid I

	产品编号	CFN90538
	CAS编号	122168-40-5
	分子式 = 分子量	C₄₃H₆₆O₁₄ = 806.97
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Gymnema sylvestre (Retz.) Schult.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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匙羹藤酸I	CFN90538	122168-40-5	1mg	QQ客服：2056216494
匙羹藤酸I	CFN90538	122168-40-5	5mg	QQ客服：2056216494
匙羹藤酸I	CFN90538	122168-40-5	10mg	QQ客服：2056216494
匙羹藤酸I	CFN90538	122168-40-5	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Monash University Sunway Campus (Malaysia)

University of Canterbury (New Zealand)

University of Limpopo (South Africa)

Research Unit Molecular Epigenetics (MEG) (Germany)

Hamdard University (India)

Osmania University (India)

St. Jude Children Research Hospital (USA)

Uniwersytet Jagielloński w Krakowie (Poland)

Heinrich-Heine-University Düsseldorf (Germany)

Universidad Miguel Hernández (Spain)

MTT Agrifood Research Finland (Finland)

Deutsches Krebsforschungszentrum (Germany)

University of Hertfordshire (United Kingdom)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

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Description:

Gymnemic acid I is a protein biosynthesis inhibitor, it as antisweet principles.

In vitro:

Journal of Natural Products,2017, 80(4).

Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics.[Reference: WebLink]

The plant Gymnema sylvestre has been used widely in traditional medicine as a remedy for several diseases, and its leaf extract is known to contain a group of bioactive triterpene saponins belonging to the gymnemic acid class.
METHODS AND RESULTS:
Gymnemic acid I (1) is one of the main components among this group of secondary metabolites and is endowed with an interesting bioactivity profile. Since there is a lack of information about its specific biological targets, the full interactome of 1 was investigated through a quantitative chemical proteomic approach, based on stable-isotope dimethyl labeling. The ribosome complex was found to be the main partner of compound 1, and a full validation of the proteomics results was achieved by orthogonal approaches.
CONCLUSIONS:
Further biochemical and biological investigations revealed an inhibitory effect of 1 on the ribosome machinery.

In vivo:

J Cell Physiol . 2019 Jun;234(6):9370-9377.

Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress[Pubmed: 30370588]

Abstract Gymnemic acid I (GA I) is a bioactive component of Gymnema sylvestre. It is an Indian traditional medicinal herb which has antidiabetic effect. However, the molecular mechanism is remaining to be elucidated. Here, we showed that high glucose promoted the rate of apoptosis, GA I decreased the apoptosis under the high glucose stress. Our further study explored that GA I increased the number of autophagosome and the ratio of light chain 3-I (LC3-I)/LC3-II in MIN-6 cells under the normal or high glucose stress by the methods of western blot analysis and immunofluorescence. It induced autophagy flux and inhibited the phosphorylation of mammalian target of rapamycin (mTOR) and ribosomal protein S6 kinase β-1 (p70 S6K/S6K1), which is a substrate of mTOR. GA I decreased the rate of apoptosis and the activity of caspase-3 under the high glucose stress. The inhibition of apoptosis and caspase-3 activity by GA I were increased after treating with autophagy inhibitor in mouse islet β cells MIN-6. Our data suggested that GA I-induced autophagy protected MIN-6 cells from apoptosis under high glucose stress via inhibition the phosphorylation activity of mTOR. Keywords: apoptosis; autophagy; gymnemic acid; high glucose.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2392 mL	6.196 mL	12.392 mL	24.7841 mL	30.9801 mL
5 mM	0.2478 mL	1.2392 mL	2.4784 mL	4.9568 mL	6.196 mL
10 mM	0.1239 mL	0.6196 mL	1.2392 mL	2.4784 mL	3.098 mL
50 mM	0.0248 mL	0.1239 mL	0.2478 mL	0.4957 mL	0.6196 mL
100 mM	0.0124 mL	0.062 mL	0.1239 mL	0.2478 mL	0.3098 mL