人参皂苷Rk3

Ginsenoside Rk3

	产品编号	CFN92593
	CAS编号	364779-15-7
	分子式 = 分子量	C₃₆H₆₀O₈ = 620.9
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The roots of Panax ginseng C. A. Mey.
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产品名称	产品编号	CAS编号	包装	QQ客服
人参皂苷Rk3	CFN92593	364779-15-7	1mg	QQ客服：215959384
人参皂苷Rk3	CFN92593	364779-15-7	5mg	QQ客服：215959384
人参皂苷Rk3	CFN92593	364779-15-7	10mg	QQ客服：215959384
人参皂苷Rk3	CFN92593	364779-15-7	20mg	QQ客服：215959384

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Description:

Ginsenoside Rk3 is often used as a major ingredient of the compound preparation for ischemic heart diseases, it could have a role in treating inflammatory diseases. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC50 of 14.24±1.30 μM in HepG2 cells.

Targets:

Bcl-2/Bax | Caspase | Akt | Nrf2 | HO-1 | MAPK | NF-κB

In vitro:

Evid Based Complement Alternat Med. 2013;2013:690190.

Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway.[Pubmed: 23935671 ]

Cardiac hypertrophy is a thickening of the heart muscle that is associated with cardiovascular diseases such as hypertension and myocardial infarction. It occurs initially as an adaptive process against increased workloads and often leads to sudden arrhythmic deaths. Studies suggest that the lethal arrhythmia is attributed to hypertrophy-induced destabilization of cardiac electrical activity, especially the prolongation of the action potential. The reduced activity of Ito is demonstrated to be responsible for the ionic mechanism of prolonged action potential duration and arrhythmogeneity. Isosteviol (STV), a derivative of stevioside, plays a protective role in a variety of stress-induced cardiac diseases.
METHODS AND RESULTS:
Here we report effects of STV on rat ISO-induced hypertrophic cardiomyocytes. STV alleviated ISO-induced hypertrophy of cardiomyocytes by decreasing cell area of hypertrophied cardiomyocytes. STV application prevented the prolongation of action potential which was prominent in hypertrophied cells.
CONCLUSIONS:
The decrease and increase of current densities for Ito and ICaL observed in hypertrophied myocytes were both prevented by STV application. In addition, the results of qRT-PCR suggested that the changes of electrophysiological activity of Ito and ICaL are correlated to the alterations of the mRNA transcription level.

In vivo:

Food Funct . 2017 Oct 18;8(10):3723-3736.

Anticancer effects of ginsenoside Rk3 on non-small cell lung cancer cells: in vitro and in vivo[Pubmed: 28949353]

Abstract Ginsenoside Rk3 (Rk3) is present in the roots of processed Panax notoginseng herbs and it exerts anti-platelet aggregation, pro-immunogenic and cardioprotective effects. However, little is known regarding the anticancer activities of this compound, especially in lung cancer. This study was designed to investigate the anticancer effects of Rk3 on non-small cell lung cancer (NSCLC) cells and in an H460 xenograft tumor model. Our results showed that Rk3 reduced cell viability, inhibited both cell proliferation and colony formation, and induced G1 phase cell cycle arrest by downregulating the expression of cyclin D1 and CDK4 and upregulating the expression of P21. Rk3 also induced apoptosis in a concentration-dependent manner in H460 and A549 cells by Annexin V/PI staining, TUNEL assay and JC-1 staining, resulting in a change in the nuclear morphology. Moreover, Rk3 induced the activation of caspase-8, -9, and -3, promoted changes in mitochondrial membrane potential, decreased the expression of Bcl-2, increased the expression of Bax, and caused the release of cytochrome c, which indicated that the apoptosis-inducing effects of Rk3 were triggered via death receptor-mediated mitochondria-dependent pathways. Furthermore, Rk3 significantly inhibited the growth of H460 xenograft tumors without an obvious effect on the body weight of the treated mice. Histological analysis indicated that Rk3 inhibited tumor growth by altering the proliferation and morphology of tumor cells. In addition, we confirmed that Rk3 inhibited angiogenesis via CD34 staining and chick embryo chorioallantoic membrane (CAM) assay in vivo. Taken together, our findings revealed not only the anticancer effect of Rk3 on NSCLC cells but also a new promising therapeutic agent for human NSCLC.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
人参皂苷Rg4; Ginsenoside Rg4	CFN90572	126223-28-7	C₄₂H₇₀O₁₂ = 767.0	5mg	QQ客服：2056216494
3-乙酰氧基-24-羟基达玛-20,25-二烯; 3-Acetoxy-24-hydroxydammara-20,25-diene	CFN99477	143519-04-4	C₃₂H₅₂O₃ = 484.8	5mg	QQ客服：2056216494
人参皂苷Rk2; Ginsenoside Rk2	CFN92818	364779-14-6	C₃₆H₆₀O₇ = 604.9	5mg	QQ客服：1413575084
人参皂苷Rk1; Ginsenoside Rk1	CFN92644	494753-69-4	C₄₂H₇₀O₁₂ = 767.0	20mg	QQ客服：3257982914
人参皂苷Rh3; Ginsenoside Rh3	CFN99972	105558-26-7	C₃₆H₆₀O₇ = 604.86	5mg	QQ客服：3257982914
人参皂苷Rg5; Ginsenoside Rg5	CFN92643	186763-78-0	C₄₂H₇₀O₁₂ = 767.0	10mg	QQ客服：1413575084
达木林A; Damulin A	CFN91838	1202868-74-3	C₄₂H₇₀O₁₃ = 783.0	5mg	QQ客服：1457312923
达木林B; Damulin B	CFN91837	1202868-75-4	C₄₂H₇₀O₁₃ = 783.0	5mg	QQ客服：1457312923
人参皂苷Rk3; Ginsenoside Rk3	CFN92593	364779-15-7	C₃₆H₆₀O₈ = 620.9	10mg	QQ客服：1457312923
人参皂苷Rg6; Ginsenoside Rg6	CFN90565	147419-93-0	C₄₂H₇₀O₁₂ = 766.5	5mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6106 mL	8.0528 mL	16.1057 mL	32.2113 mL	40.2641 mL
5 mM	0.3221 mL	1.6106 mL	3.2211 mL	6.4423 mL	8.0528 mL
10 mM	0.1611 mL	0.8053 mL	1.6106 mL	3.2211 mL	4.0264 mL
50 mM	0.0322 mL	0.1611 mL	0.3221 mL	0.6442 mL	0.8053 mL
100 mM	0.0161 mL	0.0805 mL	0.1611 mL	0.3221 mL	0.4026 mL

人参皂苷Rk3

Ginsenoside Rk3

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