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  • 灵芝酸D

    Ganoderic acid D

    产品编号 CFN90292
    CAS编号 108340-60-9
    分子式 = 分子量 C30H42O7 = 514.66
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸D CFN90292 108340-60-9 10mg QQ客服:1457312923
    灵芝酸D CFN90292 108340-60-9 20mg QQ客服:1457312923
    灵芝酸D CFN90292 108340-60-9 50mg QQ客服:1457312923
    灵芝酸D CFN90292 108340-60-9 100mg QQ客服:1457312923
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    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

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  • 生物活性
    Description: Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(50) value of 17.3 +/- 0.3 microM.
    In vitro:
    Mol Cell Proteomics. 2008 May;7(5):949-61.
    Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network.[Pubmed: 18166740]
    Triterpenes isolated from Ganoderma lucidum could inhibit the growth of numerous cancer cell lines and were thought to be the basis of the anticancer effects of G. lucidum. Ganoderic acid D (GAD) is one of the major components in Ganoderma triterpenes. GAD treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with an IC(50) value of 17.3 +/- 0.3 microM. Flow cytometric analysis and DNA fragmentation analysis indicated that Ganoderic acid D induced G(2)/M cell cycle arrest and apoptosis.
    To identify the cellular targets of Ganoderic acid D, two-dimensional gel electrophoresis was performed, and proteins altered in expressional level after Ganoderic acid D exposure of cells were identified by MALDI-TOF MS/MS. The regulation of proteins was also confirmed by Western blotting. The cytotoxic effect of Ganoderic acid D was associated with regulated expression of 21 proteins. Furthermore these possible Ganoderic acid D target-related proteins were evaluated by an in silico drug target searching program, INVDOCK. The INVDOCK analysis results suggested that Ganoderic acid D could bind six isoforms of 14-3-3 protein family, annexin A5, and aminopeptidase B. The direct binding affinity of Ganoderic acid D toward 14-3-3 zeta was confirmed in vitro using surface plasmon resonance biosensor analysis. In addition, the intensive study of functional association among these 21 proteins revealed that 14 of them were closely related in the protein-protein interaction network. They had been found to either interact with each other directly or associate with each other via only one intermediate protein from previous protein-protein interaction experimental results. When the network was expanded to a further interaction outward, all 21 proteins could be included into one network.
    In this way, the possible network associated with Ganoderic acid D target-related proteins was constructed, and the possible contribution of these proteins to the cytotoxicity of Ganoderic acid D is discussed in this report.
    Eur J Pharmacol . 2018 Apr 5;824:72-77.
    Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D[Pubmed: 29374515]
    Abstract Ganoderic acid D (GAD) is a highly oxygenated tetracyclic triterpenoid. This study aims to assess the effects of GAD on the energy metabolism of colon cancer through the regulation of SIRT3 expression and whether this effect is related to acetylated cyclophilin D. The results demonstrated that GAD inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. Meanwhile, GAD upregulated the protein expression of SIRT3. Furthermore, the interruption of SIRT3 expression significantly reversed all the effects of SIRT3 on the energy reprogramming of colon cancer. In addition, GAD induced the deacetylated cyclophilin D (CypD) by SIRT3, whereas SIRT3-shRNA inhibited its combining effect on CypD. The energy reprogramming effects of GAD on colon cancer seem to be mediated by SIRT3 upregulation via acetylated CypD inhibition. Keywords: Colon cancer; Cyclophilin D; Ganoderic acid D; Glucose metabolism; SIRT3; Warburg effect.
    In vivo:
    Drug Metab Dispos. 2012 Dec;40(12):2307-14.
    Identification of metabolites of ganoderic acid D by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.[Pubmed: 22942320]
    Ganoderic acid D (GD) is the major active triterpenoid in Ganoderma lucidum, a medicinal fungus used daily. However, the metabolic fate of Ganoderic acid D remains unknown. To know whether Ganoderic acid D is extensively metabolized, we first investigated the metabolism of Ganoderic acid D in vitro and in vivo.
    The metabolic profiles of the bile samples obtained from rats in vivo were almost the same as those obtained in vitro. Using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry, a total of 25 metabolites were identified from the bile sample. Few metabolites were found in the urine samples. These results indicated that biliary rather than renal clearance was the major route of excretion. The major metabolites were identified by comparison with the standard reference compounds. Metabolites at low concentrations were identified by interpreting the mass spectra. Both phase I and phase II metabolites were observed. The metabolic transformation included reduction, monohydroxylation, dihydroxylation, trihydroxylation, oxidation, desaturation, sulfation, and glucuronidation. The main metabolic soft spots in the chemical structure of Ganoderic acid D were the 3-carbonyl group, angular methyl groups, the 7-hydroxy group, and the 26-carboxylic acid moiety.
    Overall, this study gives us an insight into the metabolism of Ganoderic acid D, an active oxygenated tetracyclic triterpenoid.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.943 mL 9.7152 mL 19.4303 mL 38.8606 mL 48.5758 mL
    5 mM 0.3886 mL 1.943 mL 3.8861 mL 7.7721 mL 9.7152 mL
    10 mM 0.1943 mL 0.9715 mL 1.943 mL 3.8861 mL 4.8576 mL
    50 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.7772 mL 0.9715 mL
    100 mM 0.0194 mL 0.0972 mL 0.1943 mL 0.3886 mL 0.4858 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    赤芝酸G甲酯; Methyl lucidenate G CFN95058 102607-20-5 C28H42O7 = 490.6 5mg QQ客服:1413575084
    灵芝酸C1; Ganoderic acid C1 CFN92053 95311-97-0 C30H42O7 = 514.7 5mg QQ客服:1413575084
    灵芝酸LM2; Ganoderic acid LM2 CFN90297 508182-41-0 C30H42O7 = 514.66 10mg QQ客服:1457312923
    灵芝烯酸G; Ganoderenic acid G CFN95517 120481-73-4 C30H40O7 = 512.6 5mg QQ客服:3257982914
    灵芝酸 J; Ganoderic acid J CFN95516 100440-26-4 C30H42O7 = 514.7 10mg QQ客服:2159513211
    灵芝酸D; Ganoderic acid D CFN90292 108340-60-9 C30H42O7 = 514.66 20mg QQ客服:2056216494
    灵芝酸D甲酯; Methyl ganoderate D CFN95581 97210-12-3 C31H44O7 = 528.7 5mg QQ客服:1457312923
    12-羟基灵芝酸D; 12-Hydroxyganoderic acid D CFN91921 942950-96-1 C30H42O8 = 530.65 5mg QQ客服:2159513211
    12-乙酰氧基灵芝酸D; 12-Acetoxy ganoderic acid D CFN95535 N/A C32H44O9 = 572.7 5mg QQ客服:1413575084
    12β-灵芝酸M; Ganoderic acid M CFN90747 100761-17-9 C30H42O8 = 530.7 10mg QQ客服:215959384





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