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  • 灵芝烯酸B

    Ganoderenic acid B

    灵芝烯酸B
    产品编号 CFN92991
    CAS编号 100665-41-6
    分子式 = 分子量 C30H42O7 = 514.65
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝烯酸B CFN92991 100665-41-6 1mg QQ客服:2159513211
    灵芝烯酸B CFN92991 100665-41-6 5mg QQ客服:2159513211
    灵芝烯酸B CFN92991 100665-41-6 10mg QQ客服:2159513211
    灵芝烯酸B CFN92991 100665-41-6 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Perugia (Italy)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • National Cancer Institute (USA)
  • Universitas Airlangga (Indonesia)
  • Macau University of Science and Technology (China)
  • Shanghai University of TCM (China)
  • National Hellenic Research Foundation (Greece)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • Phytother Res.2022, ptr.7573.
  • LWT2021, 138:110397.
  • ACS Omega2020, 5,33,20825-20830
  • Phytomedicine.2021, 93:153789.
  • J AOAC Int.2021, 104(6):1634-1651.
  • Molecules2022, 27(3),1140.
  • Pharmaceutics2022, 14(2),376.
  • Separation Science Plus2022, sscp.202200048.
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Front Nutr.2021, 8: 687851.
  • J Am Soc Mass Spectrom.2021, 32(5):1205-1214.
  • Nutraceutical Research . 2021, 19(1),p90-105.
  • J Ethnopharmacol.2020, 249:112396
  • Processes2021, 9(11),2065.
  • Cancer Sci.2022, 113(4):1406-1416.
  • Invest New Drugs.2017, 35(2):166-179
  • Appl. Sci. 2021, 11(23),11099.
  • Microchemical Journal2018, 137:168-173
  • Nutrients.2023, 15(13):2960.
  • Journal of Apicultural Research2021, 60(1).
  • FEBS Lett.2021, 595(20):2608-2615.
  • ...
  • 生物活性
    Description: Ganoderenic acid B can enhance the cytotoxicity of chemotherapeutics towards ABCB1-mediated MDR cancer cells via inhibition of the transport function of ABCB1.
    In vitro:
    Int J Oncol. 2015 May;46(5):2029-38.
    Ganoderma lucidum derived ganoderenic acid B reverses ABCB1-mediated multidrug resistance in HepG2/ADM cells.[Pubmed: 25779097 ]
    Chemotherapy is one of the most common therapeutic option for metastatic tumors and hematological malignancies. ABCB1-mediated multidrug resistance is the major obstacle for chemotherapy. Natural products with diversified structures are ideal source of ABCB1 modulators.
    METHODS AND RESULTS:
    Ganoderenic acid B, a lanostane-type triterpene isolated from Ganoderma lucidum, exhibited potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to doxorubicin, vincristine and paclitaxel. Similarly, Ganoderenic acid B could also significantly reverse the resistance of ABCB1-overexpressing MCF-7/ADR cells to doxorubicin. Furthermore, Ganoderenic acid B notably enhanced intracellular accumulation of rhodamine-123 in HepG2/ADM cells through inhibition of its efflux. ABCB1 siRNA interference assay indicated that the reversal activity of Ganoderenic acid B was dependent on ABCB1. Further mechanistic investigations found that Ganoderenic acid B did not alter the expression level of ABCB1 and the activity of ABCB1 ATPase. Molecular docking model displayed that the positions of Ganoderenic acid B binding to ABCB1 were different from the region of verapamil interacted with ABCB1.
    CONCLUSIONS:
    Collectively, Ganoderenic acid B can enhance the cytotoxicity of chemotherapeutics towards ABCB1-mediated MDR cancer cells via inhibition of the transport function of ABCB1. These findings provide evidence that Ganoderenic acid B has the potential to be developed into an ABCB1-mediated multidrug resistance reversal agent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9431 mL 9.7153 mL 19.4307 mL 38.8614 mL 48.5767 mL
    5 mM 0.3886 mL 1.9431 mL 3.8861 mL 7.7723 mL 9.7153 mL
    10 mM 0.1943 mL 0.9715 mL 1.9431 mL 3.8861 mL 4.8577 mL
    50 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.7772 mL 0.9715 mL
    100 mM 0.0194 mL 0.0972 mL 0.1943 mL 0.3886 mL 0.4858 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸A甲酯; Methyl ganoderate A CFN95550 105742-78-7 C31H46O7 = 530.7 5mg QQ客服:2056216494
    赤芝酸G甲酯; Methyl lucidenate G CFN95058 102607-20-5 C28H42O7 = 490.6 5mg QQ客服:2056216494
    灵芝酸C1; Ganoderic acid C1 CFN92053 95311-97-0 C30H42O7 = 514.7 5mg QQ客服:3257982914
    灵芝酸LM2; Ganoderic acid LM2 CFN90297 508182-41-0 C30H42O7 = 514.66 10mg QQ客服:1413575084
    灵芝烯酸G; Ganoderenic acid G CFN95517 120481-73-4 C30H40O7 = 512.6 5mg QQ客服:1457312923
    灵芝酸 J; Ganoderic acid J CFN95516 100440-26-4 C30H42O7 = 514.7 10mg QQ客服:1457312923
    灵芝酸D; Ganoderic acid D CFN90292 108340-60-9 C30H42O7 = 514.66 20mg QQ客服:1457312923
    灵芝酸D甲酯; Methyl ganoderate D CFN95581 97210-12-3 C31H44O7 = 528.7 5mg QQ客服:3257982914
    12-羟基灵芝酸D; 12-Hydroxyganoderic acid D CFN91921 942950-96-1 C30H42O8 = 530.65 5mg QQ客服:2056216494
    12-乙酰氧基灵芝酸D; 12-Acetoxy ganoderic acid D CFN95535 N/A C32H44O9 = 572.7 5mg QQ客服:215959384

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