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  • 麻黄根素A

    Ephedrannin A

    麻黄根素A
    产品编号 CFN95579
    CAS编号 82001-39-6
    分子式 = 分子量 C30H20O11 = 556.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Ephedra sinica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    麻黄根素A CFN95579 82001-39-6 1mg QQ客服:215959384
    麻黄根素A CFN95579 82001-39-6 5mg QQ客服:215959384
    麻黄根素A CFN95579 82001-39-6 10mg QQ客服:215959384
    麻黄根素A CFN95579 82001-39-6 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

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    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
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    PMID: 28005066

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    IF=12.804(2019)

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  • 生物活性
    Description: Ephedrannin A has Anti-melanogenesis activity. Ephedrannin A has anti-inflammatory activity.
    In vitro:
    Biochim Biophys Acta . 2015 Jul;1850(7):1389-1396.
    Inhibitory effect of ephedrannins A and B from roots of Ephedra sinica STAPF on melanogenesis[Pubmed: 25857772]
    Background: Melanogenesis, a process producing the pigment melanin in human skin, eyes and hair, is a major physiological response against various environmental stresses, in particular exposure to ultraviolet radiation, and its pathway is regulated by a key enzyme, tyrosinase. In this study, we evaluated the effects of ephedrannins A and B, which are polyphenols from the roots of Ephedra sinica, commonly used in herbalism in oriental countries, on mushroom tyrosinase and melanogenesis in B16F10 melanoma cells. Methods: Their effects on mushroom tyrosinase were determined via kinetic studies using a spectrophotometric analysis and those on melanin and tyrosinase production in melanoma cells treated with α-MSH (melanin stimulating hormone) were examined using PCR and ELISA. Results: Both ephedrannins A and B exhibited concentration-dependent inhibitory effects on L-tyrosine oxidation by mushroom tyrosinase, and the inhibition mechanism was competitive and reversible with L-tyrosine as the substrate. In addition, melanin production in melanoma cells was also suppressed in a concentration-dependent manner by ephedrannins A and B without significant effects on cell proliferation at the concentrations tested. Both compounds showed inhibitory effects on melanin production by suppressing the transcription of tyrosinase in the cells. Conclusion: Both compounds exhibited significant inhibitory effects, but the inhibition by ephedrannin B was much more effective than that by ephedrannin A. Both ephedrannins A and B may be good candidates for a whitening agent for skin. General significance: This is the first report that describes effective inhibition of melanin production by ephedrannins A and B isolated from Ephedra roots.
    Int Immunopharmacol . 2010 Dec;10(12):1616-1625.
    Ephedrannin A and B from roots of Ephedra sinica inhibit lipopolysaccharide-induced inflammatory mediators by suppressing nuclear factor-κB activation in RAW 264.7 macrophages[Pubmed: 20939997]
    Ephedra sinica is a traditional Chinese medicinal herb and has pharmacological functions including anti-inflammatory effects. However, the active ingredients from Ephedra roots have not been characterized. Here, two active constituents were isolated and their structures and mechanisms of action were defined. Active constituents from Ephedra roots were isolated by continuous solvent-extractions and column chromatography. Their structures were determined by use of multiple types of spectrometry. The mechanisms of action were examined using lipopolysaccharide (LPS)-stimulated RAW 264.7 cells through PCR, ELISA, electrophoretic mobility shift assays, and immunocytochemistry. Two active constituents, ephedrannin A and B, belonging to the A-type proanthocyanidin family were identified. Both ephedrannin A and B effectively suppressed the transcription of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). These compounds exerted their anti-inflammatory actions on LPS-stimulated macrophages by suppressing the translocation of nuclear factor-kappa B (NF-κB) and the phosphorylation of p38 mitogen-activated protein (MAP) kinase. Ephedrannin A and B both exhibited strong anti-inflammatory effects, however, the optimal dose of ephedrannin B was 10 times lower than that of ephedrannin A. This is the first report describing effective anti-inflammatory activity for ephedrannin A and B isolated from Ephedra roots. Ephedrannin B may be a good candidate for delaying the progression of human inflammatory diseases and warrants further studies.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7969 mL 8.9847 mL 17.9695 mL 35.9389 mL 44.9236 mL
    5 mM 0.3594 mL 1.7969 mL 3.5939 mL 7.1878 mL 8.9847 mL
    10 mM 0.1797 mL 0.8985 mL 1.7969 mL 3.5939 mL 4.4924 mL
    50 mM 0.0359 mL 0.1797 mL 0.3594 mL 0.7188 mL 0.8985 mL
    100 mM 0.018 mL 0.0898 mL 0.1797 mL 0.3594 mL 0.4492 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    血竭黄烷C1; Dracoflavan C1 CFN92680 194794-49-5 C33H30O6 = 522.6 5mg QQ客服:2056216494
    血竭黄烷B1; Dracoflavan B1 CFN92682 194794-44-0 C33H30O7 = 538.6 5mg QQ客服:1457312923
    血竭黄烷B2; Dracoflavan B2 CFN92683 194794-47-3 C33H30O7 = 538.6 5mg QQ客服:1413575084
    瑞香酚; Stelleranol CFN91960 795308-62-2 C30H22O11 = 558.49 5mg QQ客服:1413575084
    芫花酚B; Genkwanol B CFN91961 142674-67-7 C30H22O11 = 558.49 5mg QQ客服:2056216494
    芫花酚C; Genkwanol C CFN91962 151283-11-3 C30H22O11 = 558.49 5mg QQ客服:2159513211
    麻黄宁G; Mahuannin G CFN95553 N/A C30H22O10 = 542.5 5mg QQ客服:215959384
    麻黄宁J; Mahuannin J CFN95533 N/A C30H20O11 = 556.5 5mg QQ客服:3257982914
    Abiesinol B; Abiesinol B CFN95599 1190070-89-3 C30H22O11 = 558.5 5mg QQ客服:2159513211
    Abiesinol A; Abiesinol A CFN95600 1190070-88-2 C30H22O11 = 558.5 5mg QQ客服:2056216494

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