甘草酸二钾盐

Dipotassium Glycyrrhizinate

	产品编号	CFN93273
	CAS编号	68797-35-3
	分子式 = 分子量	C₄₂H₆₂K₂O₁₇ = 917.13
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The roots of Glycyrrhiza glabra.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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甘草酸二钾盐	CFN93273	68797-35-3	1mg	QQ客服：2159513211
甘草酸二钾盐	CFN93273	68797-35-3	5mg	QQ客服：2159513211
甘草酸二钾盐	CFN93273	68797-35-3	10mg	QQ客服：2159513211
甘草酸二钾盐	CFN93273	68797-35-3	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Indonesia (Indonesia)

National Cancer Institute (USA)

University of Otago (New Zealand)

Mahidol University (Thailand)

Worcester Polytechnic Institute (USA)

Monash University Malaysia (Malaysia)

Indian Institute of Science (India)

Universite de Lille1 (France)

University of Wisconsin-Madison (USA)

Universidade de Franca (Brazil)

University of Limpopo (South Africa)

Kyushu University (Japan)

Medizinische Universit?t Wien (Austria)

Sanford Burnham Prebys Medical Discovery Institute (USA)

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Description:

Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.

In vitro:

Int J Pharm. 2002 Jul 25;241(2):319-27.

Elastic liposomes for skin delivery of dipotassium glycyrrhizinate.[Pubmed: 12100859]

The aim of this study was to evaluate the possibility of using liposomes for skin delivery of Dipotassium Glycyrrhizinate (KG), an anti-inflammatory agent employed in treating acute and chronic dermatitis, and of formulating such liposomes in an oil-in-water emulsion (O/W). KG had emulsifying properties and the possibility of producing elastic liposomes was verified.
METHODS AND RESULTS:
Liposomes containing soya lecithin (PC) or hydrogenated soya lecithin (HPC) mixed with KG in w/w ratios of 2:1, 4:1 or 8:1 were prepared by the solvent evaporation method and then passed through a high pressure homogeniser. Liposome size and entrapment efficiency were determined and the interaction between KG and HPC was investigated using differential scanning calorimetry (DSC). Transepidermal permeation through intact pig skin and skin deposition of KG from liposomes and O/W emulsion containing liposomes were assessed and compared with values for aqueous control solutions. No marked differences were observed between PC and HPC liposomes. Liposome sizes ranged from 90 to 120 nm. Entrapment efficiency depended on the lipid:KG ratio; the maximum efficiency was obtained at 4:1 w/w. KG interacted with liposomes disrupting and fluidising the lipid bilayer, forming elastic liposomes able to penetrate through membrane pores of diameter much smaller than their own diameter. The liposome structure was maintained when dispersed in an O/W emulsion.
CONCLUSIONS:
The skin fluxes were less than the HPLC detection limit for all systems, while skin deposition increased 4.5-fold compared with aqueous solutions when KG was formulated in liposomes.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
伽升沃C; Garcinone C	CFN97254	76996-27-5	C₂₃H₂₆O₇ = 414.5	10mg	QQ客服：1413575084
瑞香苷; Daphnin	CFN80132	486-55-5	C₁₅H₁₆O₉ = 340.3	5mg	QQ客服：2056216494
台湾高黄酮 A; Taiwanhomoflavone A	CFN96541	265120-00-1	C₃₃H₂₄O₁₀ = 580.55	5mg	QQ客服：1413575084
α-托可醌; alpha-Tocopherolquinone	CFN97235	7559-04-8	C₂₉H₅₀O₃ = 446.7	20mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0904 mL	5.4518 mL	10.9036 mL	21.8072 mL	27.2589 mL
5 mM	0.2181 mL	1.0904 mL	2.1807 mL	4.3614 mL	5.4518 mL
10 mM	0.109 mL	0.5452 mL	1.0904 mL	2.1807 mL	2.7259 mL
50 mM	0.0218 mL	0.109 mL	0.2181 mL	0.4361 mL	0.5452 mL
100 mM	0.0109 mL	0.0545 mL	0.109 mL	0.2181 mL	0.2726 mL