二氢菜豆酸

Dihydrophaseic acid

	产品编号	CFN98657
	CAS编号	41756-77-8
	分子式 = 分子量	C₁₅H₂₂O₅ = 282.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The herbs of Echinocystis macrocarpa
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
二氢菜豆酸	CFN98657	41756-77-8	1mg	QQ客服：2159513211
二氢菜豆酸	CFN98657	41756-77-8	5mg	QQ客服：2159513211
二氢菜豆酸	CFN98657	41756-77-8	10mg	QQ客服：2159513211
二氢菜豆酸	CFN98657	41756-77-8	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Ateneo de Manila University (Philippines)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Monash University Malaysia (Malaysia)

Universidade da Beira Interior (Germany)

Worcester Polytechnic Institute (USA)

University of Lodz (Poland)

Nanjing University of Chinese Medicine (China)

University of Otago (New Zealand)

Universidade Católica Portuguesa (Portugal)

Cornell University (USA)

Helmholtz Zentrum München (Germany)

University of Vienna (Austria)

University of Madras (India)

Mahatma Gandhi University (India)

More...

Description:

Dihydrophaseic acid 3’-O-b-D-glucopyranoside (D3G) can increase the proliferation and differentiation of osteoblast cells and enhance bone formation, suggests that D3G may be a good candidate for the treatment of osteoporosis.

In vitro:

Osteoporosis and Sarcopenia 2015,1(2):137-8.

Antiosteoporotic Activity of Dihydrophaseic Acid 3′-O-b-D-Glucopyranoside Derivatives from Lycii Radicis Cortex.[Reference: WebLink]

Our previous study demonstrated that ethanol extract of Lycii Radicis Cortex (LRC) prevented the ovariectomized-induced bone mineral density loss in mice via promoting the differentiation of osteoblast linage cells. A single compound, D3G, was isolated from the LRC extract as a candidate component enhancing bone formation. The aim of this study was to investigate the antiosteoporotic effects of Dihydrophaseic acid 3ʹ-O-b-D-glucopyranoside (D3G).
METHODS AND RESULTS:
The highest alkaline phosphatase activity was observed with 5 μg/ml of D3G in both cell lines: C3H10T1/2 and MC3T3-E1. The D3G treatment for 21 days increased the mineralized nodule formation in the MC3T3-E1 cell line. The expression of osteoblastic markers, Alpl, Runx2, and Bglap, was significantly increased in the D3G-treated cells compared to the non-treated control cells. The D3G treatment did not influence osteoclast differentiation in primary-cultured monocytes of mouse bone marrow. In coculture of monocytes and MC3T3-E1 cells, however, D3G induced both osteoblast and osteoclast differentiation.
CONCLUSIONS:
This study demonstrated that D3G increased the proliferation and differentiation of osteoblast cells and enhanced bone formation. These results suggest that D3G may be a good candidate for the treatment of osteoporosis

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Ascleposide E; Ascleposide E	CFN98414	325686-49-5	C₁₉H₃₂O₈ = 388.5	5mg	QQ客服：2159513211
Citroside A ; Citroside A	CFN96992	120330-44-1	C₁₉H₃₀O₈ = 386.44	5mg	QQ客服：1457312923
淫羊藿次甙 B1 ; Icariside B1	CFN96968	109062-00-2	C₁₉H₃₀O₈ = 386.44	5mg	QQ客服：3257982914
二氢菜豆酸; Dihydrophaseic acid	CFN98657	41756-77-8	C₁₅H₂₂O₅ = 282.3	5mg	QQ客服：215959384
二氢菜豆酸 4'-O-葡萄糖苷; Dihydrophaseic acid 4'-O-beta-D-glucopyranoside	CFN95393	78914-56-4	C₂₁H₃₂O₁₀ = 444.5	5mg	QQ客服：215959384
8'-Oxo-6-hydroxydihydrophaseic acid ; 8'-Oxo-6-hydroxydihydrophaseic acid	CFN96741	1388075-44-2	C₁₅H₂₀O₇ = 312.31	5mg	QQ客服：215959384
脱落酸; Abscisic acid	CFN90051	21293-29-8	C₁₅H₂₀O₄ = 264.32	20mg	QQ客服：1457312923
8'-O-(3-hydroxy-3-methylglutaryl)-8'-hydroxyabscisic acid; 8'-O-(3-hydroxy-3-methylglutaryl)-8'-hydroxyabscisic acid	CFN95308	69790-31-4	C₂₁H₂₈O₉ = 424.4	5mg	QQ客服：3257982914
Breyniaionoside A; Breyniaionoside A	CFN96810	823182-23-6	C₁₉H₃₂O₉ = 404.45	5mg	QQ客服：1457312923
Cucumegastigmane I; Cucumegastigmane I	CFN97498	929881-46-9	C₁₃H₂₀O₄ = 240.3	5	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5423 mL	17.7117 mL	35.4233 mL	70.8466 mL	88.5583 mL
5 mM	0.7085 mL	3.5423 mL	7.0847 mL	14.1693 mL	17.7117 mL
10 mM	0.3542 mL	1.7712 mL	3.5423 mL	7.0847 mL	8.8558 mL
50 mM	0.0708 mL	0.3542 mL	0.7085 mL	1.4169 mL	1.7712 mL
100 mM	0.0354 mL	0.1771 mL	0.3542 mL	0.7085 mL	0.8856 mL