DL-丁香树脂酚
DL-Syringaresinol
|
|
产品编号 |
CFN99276 |
| CAS编号 |
1177-14-6 |
| 分子式 = 分子量 |
C22H26O8 = 418.4 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Lignans |
| 植物来源 |
The herbs of Liriodendron tulipifera |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| DL-丁香树脂酚 |
CFN99276 |
1177-14-6 |
1mg |
QQ客服：3257982914 |
| DL-丁香树脂酚 |
CFN99276 |
1177-14-6 |
5mg |
QQ客服：3257982914 |
| DL-丁香树脂酚 |
CFN99276 |
1177-14-6 |
10mg |
QQ客服：3257982914 |
| DL-丁香树脂酚 |
CFN99276 |
1177-14-6 |
20mg |
QQ客服：3257982914 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Chiang Mai University (Thailand)
Mahatma Gandhi University (India)
University of Zurich (Switzerland)
Kyung Hee University (Korea)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
Ain Shams University (Egypt)
Funda??o Universitária de Desenvolvimento (Brazil)
National Cancer Center Research Institute (Japan)
Almansora University (Egypt)
Nanjing University of Chinese Medicine (China)
Lund University (Sweden)
CSIRO - Agriculture Flagship (Australia)
National Research Council of Canada (Canada)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
(+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml. (-)-Syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G 1 arrest and induction of apoptosis, suggests that it may be a potential chemotherapeutic agent for the treatment of cancer. Syringaresinol induces vasorelaxation by enhancing NO production in endothelial cells via two distinct mechanisms, phosphatidylinositol 3-kinase/Akt- and (PLC)/Ca2+/CaMKKβ -dependent eNOS phosphorylation and Ca(2+)-dependent eNOS dimerization. Syringaresinol also can protect against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism. |
| Targets: |
Antifection | PI3K | Akt | Calcium Channel | NOS | HIF | NO |
| In vitro: |
| Biol Pharm Bull. 2006 Jan;29(1):172-3. | | Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese aprico[Pubmed: 16394533] |
METHODS AND RESULTS:
A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 microg/ml and the IC50 value was 50 microg/ml. | | Int Immunopharmacol. 2008 Jul;8(7):967-73. | | (-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis.[Pubmed: 18486907] |
METHODS AND RESULTS:
The induction of apoptosis after treatment with (-)-syringaresinol for 24 h was demonstrated by morphological changes, DNA fragmentation, altered ratio of Bax/Bcl-2, cleavage of poly(ADP-ribose) polymerase and flow cytometry analysis. (-)-Syringaresinol also induced cytochrome c release and activation of caspase-3 and caspase-9. To our knowledge, this is the first time that (-)-syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis.
CONCLUSIONS:
These findings suggest that (-)-syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.3901 mL |
11.9503 mL |
23.9006 mL |
47.8011 mL |
59.7514 mL |
| 5 mM |
0.478 mL |
2.3901 mL |
4.7801 mL |
9.5602 mL |
11.9503 mL |
| 10 mM |
0.239 mL |
1.195 mL |
2.3901 mL |
4.7801 mL |
5.9751 mL |
| 50 mM |
0.0478 mL |
0.239 mL |
0.478 mL |
0.956 mL |
1.195 mL |
| 100 mM |
0.0239 mL |
0.1195 mL |
0.239 mL |
0.478 mL |
0.5975 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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