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  • 环(甘氨酸-L-脯氨酸)二肽

    Cyclo(Gly-L-Pro)

    环(甘氨酸-L-脯氨酸)二肽
    产品编号 CFN96160
    CAS编号 3705-27-9
    分子式 = 分子量 C7H10N2O2 = 154.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Panax notoginseng (Burk.)F.H.Chen
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    环(甘氨酸-L-脯氨酸)二肽 CFN96160 3705-27-9 1mg QQ客服:1148253675
    环(甘氨酸-L-脯氨酸)二肽 CFN96160 3705-27-9 5mg QQ客服:1148253675
    环(甘氨酸-L-脯氨酸)二肽 CFN96160 3705-27-9 10mg QQ客服:1148253675
    环(甘氨酸-L-脯氨酸)二肽 CFN96160 3705-27-9 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Beira Interior (Portugal)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Calcutta University (India)
  • Universidad Veracuzana (Mexico)
  • Universidade da Beira Interior (Germany)
  • Siksha O Anusandhan University (India)
  • University of Wuerzburg (Germany)
  • Sri Ramachandra University (India)
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  • Amity University (India)
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  • National Chung Hsing University (Taiwan)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Herb. Med. Inf.2021, 9(2):231-239.
  • Appl. Sci.2021, 11(19),9343.
  • Foods.2021, 10(6):1378.
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Plant J.2021, 107(6):1711-1723.
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • JLiquid Chromatography & Related Tech.2021, 10826076.
  • Analytical sci. & Tech2020, 33(5):224-231
  • Biomol Ther (Seoul).2019, 10.4062
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • FEBS Lett.2015, 589(1):182-7
  • Cytotechnology.2017, 69(5):765-773
  • Sci Rep.2017, 7:467-479
  • Int J Mol Sci.2018, 19(9):E2681
  • Nutrients.2019, 12(1):E40
  • Oncotarget.2017, 9(3):4161-4172
  • Front Plant Sci.2020, 10:1705
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • J Nat Prod.2021, 84(9):2544-2553.
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Ann Transl Med.2019, 7(23):731
  • Pest Manag Sci.2019, 75(9):2530-2541
  • Process Biochemistry2019, 87:213-220
  • ...
  • 生物活性
    Description: Cyclo(Gly-(L)-Pro) shows immunostimulatory properties. Cyclo(Gly-l-Pro) exhibits potent inhibition of TNF-α release with the IC50 values of 4.5 ug/mL, respectively, it also exhibits significant diminution of IL-1β and IL-6 mRNA-expression levels and NO production.
    Targets: IFN-γ | IL Receptor | TNF-α | NO
    In vitro:
    Scand J Immunol. 2012 Aug;76(2):131-40.
    Induction of immune-related gene expression in Ctenopharyngodon idella kidney cells by secondary metabolites from immunostimulatory Alcaligenes faecalis FY-3.[Pubmed: 22606987 ]
    This study was undertaken to isolate active secondary metabolites from immunostimulatory Alcaligenes faecalis FY-3 and evaluate their activities using grass carp Ctenopharyngodon idella kidney (CIK) cells.
    METHODS AND RESULTS:
    By applying chromatography techniques and successive recrystallization, three purified metabolites were obtained and identified by spectral data (mass spectrometry and nuclear magnetic resonance) as: (1) phenylacetic acid, (2) p-hydroxyphenylacetylamide and (3) Cyclo(Gly-L-Pro). CIK cells were stimulated by different concentrations (1, 10 and 100 μg/ml) of the isolated compounds, and expression of MyD88, IL-1β, TNF-α, type I-IFN and IL-8 genes at different time points (2, 8 and 24 h) post-stimulation was quantified by real-time PCR. The known immunostimulatory agent lipopolysaccharide (LPS) was used as a positive control. To analyse whether these compounds are toxic to the cells, the methyl tetrazolium assay was employed to measure changes in cell viability. The obtained results revealed that transcribing level of MyD88, an important adaptor molecule in toll-like receptor signalling pathway, was augmented remarkably by all the three isolated compounds and LPS as early as 2-h exposure. These compounds also induced gene expression of cytokines such as IL-1β, TNF-α and type I-IFN. Under the experimental conditions, none of the test compounds is toxic to the CIK cells.
    CONCLUSIONS:
    These findings demonstrate that the immunostimulatory properties of the three metabolites [phenylacetic acid, p-hydroxyphenylacetylamide and Cyclo(Gly-L-Pro) ] from A. faecalis FY-3 in CIK cells and highlight the potential of using these metabolites as immunostimulants in fish aquaculture.
    Bioorg Med Chem Lett. 2015 Dec 15;25(24):5756-61.
    Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa.[Pubmed: 26546220 ]

    METHODS AND RESULTS:
    To identify small molecule inhibitors of TNF-α, bioassay- and LC-MS-guided chemical investigation on EtOAc extract of Pseudomonas aeruginosa ABS-36 culture broth (EEPA) was performed, which yielded four proline-based cyclic dipeptides, Cyclo(Gly-L-Pro) (1), cyclo(l-Pro-l-Phe) (2), cyclo(trans-4-hydroxy-l-Pro-l-Phe) (3) and cyclo(trans-4-hydroxy-l-Pro-l-Leu) (4). Compounds 1 and 3 exhibited potent inhibition of TNF-α release with IC50 values of 4.5 and 14.2μg/mL, respectively, while EEPA showed IC50 of 38.8μg/mL under lipopolysaccharide treated RAW 264.7 cell ELISA assay. Also, marked attenuation of mRNA-expression of TNF-α was shown by all compounds. In vivo testing in rats of EEPA and chemically synthesized 4 validated significant TNF-α reduction with 51% (500mg/kg) and 79% (50mg/kg), respectively. In addition, all compounds exhibited significant diminution of IL-1β and IL-6 mRNA-expression levels and NO production.
    CONCLUSIONS:
    All samples displayed only weak toxicity to lipopolysaccharide-induced RAW 264.7 cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.4851 mL 32.4254 mL 64.8508 mL 129.7017 mL 162.1271 mL
    5 mM 1.297 mL 6.4851 mL 12.9702 mL 25.9403 mL 32.4254 mL
    10 mM 0.6485 mL 3.2425 mL 6.4851 mL 12.9702 mL 16.2127 mL
    50 mM 0.1297 mL 0.6485 mL 1.297 mL 2.594 mL 3.2425 mL
    100 mM 0.0649 mL 0.3243 mL 0.6485 mL 1.297 mL 1.6213 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    环(D-缬氨酸-L-脯氨酸); Cyclo(D-Val-L-Pro) CFN96114 27483-18-7 C10H16N2O2 = 196.3 10mg QQ客服:215959384
    环(羟脯氨酸-缬氨酸)二肽; Cyclo(Hyp-Val) CFN91062 1425501-89-8 C10H16N2O3 = 212.2 10mg QQ客服:1148253675
    环(脯氨酸-亮氨酸)二肽; Cyclo(Pro-Leu) CFN90281 5654-86-4 C11H18N2O2 = 210.27 10mg QQ客服:3257982914
    环(D-亮氨酸-L-脯氨酸)二肽; Cyclo(D-Leu-L-Pro) CFN96128 36238-67-2 C11H18N2O2 = 210.3 10mg QQ客服:2159513211
    环(羟脯氨酸-亮氨酸)二肽; Cyclo(Hpro-Leu) CFN90285 1016899-93-6 C11H18N2O3 = 226.27 10mg QQ客服:3257982914
    环(L-亮氨酸-反-4-羟基-L-脯氨酸); Cyclo(L-Leu-trans-4-hydroxy-L-Pro) CFN96088 115006-86-5 C11H18N2O3 = 226.3 10mg QQ客服:215959384
    环(脯氨酸-脯氨酸)二肽; Cyclo(Pro-Pro) CFN90270 6708-06-1 C10H14N2O2 = 194.23 10mg QQ客服:2932563308
    环(甘氨酸-L-脯氨酸)二肽; Cyclo(Gly-L-Pro) CFN96160 3705-27-9 C7H10N2O2 = 154.2 10mg QQ客服:1413575084
    环(脯氨酸-丙氨酸)二肽; Cyclo(Pro-Ala) CFN90282 65556-33-4 C8H12N2O2 = 168.20 10mg QQ客服:215959384
    环(L-丙氨酸-L-脯氨酸); Cyclo(L-Ala-L-Pro) CFN96111 36357-32-1 C8H12N2O2 = 168.2 10mg QQ客服:215959384

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