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  • 氯化失车菊素-3-O-桑布双糖苷

    Cyanidin-3-O-sambubioside chloride

    氯化失车菊素-3-O-桑布双糖苷
    产品编号 CFN92173
    CAS编号 33012-73-6
    分子式 = 分子量 C26H29ClO15 = 617.0
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Vaccinium myrtillus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    氯化失车菊素-3-O-桑布双糖苷 CFN92173 33012-73-6 1mg QQ客服:1413575084
    氯化失车菊素-3-O-桑布双糖苷 CFN92173 33012-73-6 5mg QQ客服:1413575084
    氯化失车菊素-3-O-桑布双糖苷 CFN92173 33012-73-6 10mg QQ客服:1413575084
    氯化失车菊素-3-O-桑布双糖苷 CFN92173 33012-73-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Yale University (USA)
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  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Molecules.2019, 24(17):E3127
  • Int J Mol Sci.2024, 25(5):2914.
  • Phytother Res.2022, ptr.7573.
  • Acta Physiologiae Plantarum2016, 38:7
  • Neurotox Res.2020, 38(1):163-174.
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  • Food Analytical Methods2017, 10:3225-3234
  • Mol Biol Rep.2024, 51(1):117.
  • Journal of Functional Foods2022, 91:105019.
  • Sci Rep.2023, 13(1):13610.
  • Oxid Med Cell Longev.2022, 2022:9139338.
  • Eur J Pharmacol.2022, 917:174744.
  • Nutrients.2019, 11(6):E1380
  • Biomed Pharmacother.2022, 156:113929.
  • Sustainability2021, 13(23),12981.
  • Virus Res.2023, 335:199199.
  • JAOCS2021, 98(7):779-794.
  • Microchemical Journal2024: 196:109676.
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
  • Fitoterapia.2015, 100:179-86
  • Separations2021, 8(1), 1.
  • Pharmacognosy Magazine2024, 20(2):632-645.
  • ...
  • 生物活性
    Description: Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NFκB activity. It inhibits the enzyme activity by competing with the substrate for the active site. Cyanidin-3-O-sambubioside chloride has antioxidant activity and free-radical-scavenging property.
    Targets: NF-kB | ROS
    In vitro:
    J Biomol Struct Dyn . 2018 Dec;36(16):4255-4269.
    The inhibitory performance of flavonoid cyanidin-3-sambubiocide against H274Y mutation in H1N1 influenza virus[Pubmed: 29199545]
    Abstract Oseltamivir (Tamiflu) is the most accepted antiviral drug that targets the neuraminidase (NA) protein to inhibit the viral release from the host cell. Few H1N1 influenza strains with the H274Y mutation creates drug resistance to oseltamivir. In this study, we report that flavonoid cyanidin-3-sambubiocide (C3S) compound acts as a potential inhibitor against H274Y mutation. The drug resistance mechanism and inhibitory activity of C3S and oseltamivir against wild-type (WT) and H274Y mutant-type (MT) have been studied and compared based on the results of molecular docking, molecular dynamics, and quantum chemical methods. Oseltamivir has been found less binding affinity with MT. C3S has more binding affinity with WT and MT proteins. From the dynamical study, the 150th loop of the MT protein has found more deformation than WT. A single H274Y mutation induces the conformational changes in the 150th loop which leads to produce more resistance to oseltamivir. The 150th cavity is more attractive target for C3S to stop the conformational changes in the MT, than 430th cavity of NA protein. The C3S is stabilized with MT by more number of hydrogen bonds than oseltamivir. The electrostatic interaction energy shows a stronger C3S binding with MT and this compound may be more effective against oseltamivir-resistant virus strains. Keywords: H274Y mutation; Influenza virus; drug resistance; molecular docking; molecular dynamic simulation.
    Planta Med . 2013 Nov;79(17):1636-40.
    Cyanidin-3-O-sambubioside from Acanthopanax sessiliflorus fruit inhibits metastasis by downregulating MMP-9 in breast cancer cells MDA-MB-231[Pubmed: 24214832]
    Abstract Anthocyanins play an important role in physiological functions related to human health. This study aimed to investigate the inhibitory effect of cyanidin-3-O-sambubioside isolated from Acanthopanax sessiliflorus fruit on cancer cell metastasis. The inhibitory effect of cyanidin-3-O-sambubioside on angiogenesis was assessed by chorioallantoic membrane and tube formation assays. Cyanidin-3-O-sambubioside interrupted the formation of neovasculature and tube-like structures in a dose-dependent manner. It inhibited the wound healing migration and invasion of MDA-MB-231 cells through reconstituted extracellular matrix (Matrigel). Gelatin zymography revealed that cyanidin-3-O-sambubioside significantly decreased the secretion of matrix metalloproteinase-9 and inhibited matrix metalloproteinase-9 expression. In additional, cyanidin-3-O-sambubioside exerted an inhibitory effect on Akt phosphorylation. These results suggest that cyanidin-3-O-sambubioside inhibits metastasis processes, such as angiogenesis and invasion, in breast cancer cells through regulation of matrix metalloproteinase-9 activity. Georg Thieme Verlag KG Stuttgart · New York.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6207 mL 8.1037 mL 16.2075 mL 32.4149 mL 40.5186 mL
    5 mM 0.3241 mL 1.6207 mL 3.2415 mL 6.483 mL 8.1037 mL
    10 mM 0.1621 mL 0.8104 mL 1.6207 mL 3.2415 mL 4.0519 mL
    50 mM 0.0324 mL 0.1621 mL 0.3241 mL 0.6483 mL 0.8104 mL
    100 mM 0.0162 mL 0.081 mL 0.1621 mL 0.3241 mL 0.4052 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    氯化天竺葵素; Pelargonidin chloride CFN92132 134-04-3 C15H11O5Cl = 306.7 10mg QQ客服:215959384
    氯化天竺葵素-3-O-葡萄糖苷; Pelargonidin-3-O-glucoside chloride CFN92134 18466-51-8 C21H21O10Cl = 468.8 10mg QQ客服:215959384
    氯化天竺葵素-3,5-O-双葡萄糖苷; Pelargonidin-3,5-O-diglucoside chloride CFN92170 17334-58-6 C27H31O15Cl = 631.0 5mg QQ客服:3257982914
    氯化天竺葵素-3-O-芸香糖苷; Pelargonidin-3-O-rutinoside chloride CFN92133 33978-17-5 C27H31O14Cl = 615.0 5mg QQ客服:2056216494
    木犀草定氯化物; Luteolinidin chloride CFN91858 1154-78-5 C15H11ClO5 = 306.7 5mg QQ客服:2056216494
    氯化芹菜定; Apigeninidin chloride CFN91863 1151-98-0 C15H11ClO4 = 290.7 10mg QQ客服:3257982914
    氯化非瑟酮; Fisetinidin chloride CFN91861 2948-76-7 C15H11ClO5 = 306.7 5mg QQ客服:1457312923
    刺槐定氯化物; Robinetinidin chloride CFN91856 3020-09-5 C15H11ClO6 = 322.7 10mg QQ客服:1457312923
    氯化飞燕草素-3-O-葡萄糖苷; Delphinidin-3-O-glucoside chloride CFN92038 6906-38-3 C21H21ClO12 = 500.8 10mg QQ客服:215959384
    氯化飞燕草素-3-O-半乳糖苷; Delphinidin-3-O-galactoside chloride CFN92037 28500-00-7 C21H21ClO12 = 500.8 10mg QQ客服:3257982914

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