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  • 狗牙花碱D

    Coronarin D

    狗牙花碱D
    产品编号 CFN99302
    CAS编号 119188-37-3
    分子式 = 分子量 C20H30O3 = 318.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The rhizomes of Hedychium coronarium
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    狗牙花碱D CFN99302 119188-37-3 1mg QQ客服:215959384
    狗牙花碱D CFN99302 119188-37-3 5mg QQ客服:215959384
    狗牙花碱D CFN99302 119188-37-3 10mg QQ客服:215959384
    狗牙花碱D CFN99302 119188-37-3 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland School of Medicine (USA)
  • Lund University (Sweden)
  • Florida International University (USA)
  • Max Rubner-Institut (MRI) (Germany)
  • Harvard University (USA)
  • Rio de Janeiro State University (Brazil)
  • Donald Danforth Plant Science Center (USA)
  • CSIRO - Agriculture Flagship (Australia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Universite de Lille1 (France)
  • University of Helsinki (Finland)
  • Chinese University of Hong Kong (China)
  • St. Jude Children Research Hospital (USA)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Separation Science & Technology2016, 51:1579-1588
  • Kasetsart University2022, ethesis.1144.
  • Plant Sci.2021, 313:111069.
  • Molecules2022, 27(12):3824.
  • Bioengineering2023, 10(10), 1113.
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Antioxidants2022, 11(2),234.
  • Antioxidants (Basel).2020, 9(6):466.
  • Free Radic Biol Med.2017, 112:191-199
  • Front Pharmacol.2019, 10:1355
  • Journal of Functional Foods2022, 96: 105216.
  • Phytother Res.2019, 33(4):1104-1113
  • Cell Signal.2022, 99:110433.
  • J Funct Foods2019, 54:449-456
  • Food Chem.2018, 252:207-214
  • Cells.2021, 10(11):2919.
  • Int. J. of Food Properties2017, S108-S118
  • Phytomedicine2022, 104:154337.
  • Sci Rep.2021, 11(1):11936.
  • Int J Nanomedicine.2022, 17:6513-6525.
  • Data Science for Genomics2023, 107-128.
  • Anal Sci.2019, 35(12):1317-1325
  • ...
  • 生物活性
    Description: Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, inactive for tested Gram-negative bacteria, and weakly active against tested fungi; using coronarin D-antibiotic drug combination can combat the infectious diseases.Coronarin D inhibits NF-kappaB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.
    Targets: NF-kB | Antifection | Bcl-2/Bax | Caspase | COX | c-Myc | TNF-α
    In vitro:
    Biomed Res Int. 2014;2014:581985.
    Antimicrobial activity of coronarin D and its synergistic potential with antibiotics.[Pubmed: 24949458]
    Coronarin D is a labdane-type diterpene from the rhizomes of Hedychium coronarium. In the view of our ongoing effort to explore its novel biological activity, antimicrobial activity study of Coronarin D was performed.
    METHODS AND RESULTS:
    The results showed that Coronarin D was active against tested Gram-positive bacteria, inactive for tested Gram-negative bacteria, and weakly active against tested fungi. The antibacterial effect of the combination of Coronarin D with nine classical antibiotics against four Gram-positive bacteria was also evaluated. The fractional inhibitory concentration indices (FICI) of Coronarin D-antibiotics combinations, calculated from the checkerboard assay, were used as synergism indicator. Out of 36 combinations, 47% showed total synergism, 33% had partial synergistic interaction, 17% showed no effect, and 3% showed antagonism. By combination with Coronarin D at concentration of 0.25 minimal inhibitory concentration (MIC), the activities of antibiotics were boosted to 4- to 128-fold.
    CONCLUSIONS:
    These finding suggested an attractive approach to combat the infectious diseases by using Coronarin D-antibiotic drug combination.
    Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jul;114(1):61-6.
    Antifungal activity of coronarin D against Candida albicans.[Pubmed: 22727093]
    The objective of this study was to investigate the antifungal activity of Coronarin D on Candida albicans and its activity was compared with clotrimazole and nystatin.
    METHODS AND RESULTS:
    Coronarin D was extracted by liquid chromatography and used in antifungal testing. The inhibitory effect of Coronarin D on C. albicans was determined by cultures and an applied broth dilution test. The rate of fungicidal activity was evaluated by time-kill curves. Morphologic alterations of fungal cells were investigated using scanning electron microscopy. Coronarin D was effective against C. albicans; the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively. The C. albicans killing activity of Coronarin D was higher than clotrimazole and nystatin at 2 × MFC and 4 × MFC, respectively. Morphologic alterations of fungal cells consistent with cell membrane damage were observed in the Coronarin D-treated cells.
    CONCLUSIONS:
    Coronarin D showed promising antifungal activity against C. albicans in vitro.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1397 mL 15.6986 mL 31.3972 mL 62.7943 mL 78.4929 mL
    5 mM 0.6279 mL 3.1397 mL 6.2794 mL 12.5589 mL 15.6986 mL
    10 mM 0.314 mL 1.5699 mL 3.1397 mL 6.2794 mL 7.8493 mL
    50 mM 0.0628 mL 0.314 mL 0.6279 mL 1.2559 mL 1.5699 mL
    100 mM 0.0314 mL 0.157 mL 0.314 mL 0.6279 mL 0.7849 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    15,16-Epoxy-15-ethoxy-6beta,13-dihydroxylabd-8-en-7-one; 15,16-Epoxy-15-ethoxy-6beta,13-dihydroxylabd-8-en-7-one CFN89136 1374328-47-8 C22H36O5 = 380.52 5mg QQ客服:1457312923
    Hedycoronen A; Hedycoronen A CFN89375 1383441-73-3 C21H30O3 = 330.46 5mg QQ客服:215959384
    Chinensine B; Chinensine B CFN97409 849245-34-7 C20H28O3 = 316.4 5mg QQ客服:1413575084
    牡荆内酯; Vitexilactone CFN97047 61263-49-8 C22H34O5 = 378.5 5mg QQ客服:1457312923
    12-羟基-8(17),13-赖百当二烯-16,15-内酯; 12-Hydroxy-8(17),13-labdadien-16,15-olide CFN97538 958885-86-4 C20H30O3 = 318.5 5mg QQ客服:2056216494
    Villosin; Villosin CFN99674 160598-92-5 C20H28O2 = 300.4 5mg QQ客服:1457312923
    高良姜萜内酯; Galanolactone CFN99258 115753-79-2 C20H30O3 = 318.5 5mg QQ客服:2056216494
    异姜花素D; Isocoronarin D CFN99438 138965-88-5 C20H30O3 = 318.5 5mg QQ客服:2056216494
    狗牙花碱D; Coronarin D CFN99302 119188-37-3 C20H30O3 = 318.5 5mg QQ客服:215959384
    狗牙花碱D甲醚; Coronarin D methyl ether CFN99667 157528-81-9 C21H32O3 = 332.5 5mg QQ客服:1413575084

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