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  • Confluentin

    Confluentin

    Confluentin
    产品编号 CFN98991
    CAS编号 585534-03-8
    分子式 = 分子量 C22H30O2 = 326.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Rhododendron spinuliferum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Confluentin CFN98991 585534-03-8 1mg QQ客服:215959384
    Confluentin CFN98991 585534-03-8 5mg QQ客服:215959384
    Confluentin CFN98991 585534-03-8 10mg QQ客服:215959384
    Confluentin CFN98991 585534-03-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Ain Shams University (Egypt)
  • Weizmann Institute of Science (Israel)
  • The Australian National University (Australia)
  • Harvard University (USA)
  • Medical University of South Carolina (USA)
  • Mahidol University (Thailand)
  • Universidade da Beira Interior (Germany)
  • Kazusa DNA Research Institute (Japan)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Regional Crop Research Institute (Korea)
  • Complutense University of Madrid (Spain)
  • Texas A&M University (USA)
  • National Hellenic Research Foundation (Greece)
  • Monash University Malaysia (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Korean Med Obes Res.2023, 23:10-7
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.
  • J Mass Spectrom.2022, 57(2):e4810.
  • Front Cell Dev Biol.2021, 9:638174.
  • Antioxidants (Basel).2020, 9(2):E120
  • Mol Neurobiol.2022, 02873-9.
  • Molecules2022, 27(3),1140.
  • Plants (Basel).2021, 10(5):951.
  • Scientific World Journal.2014, 2014:654193
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • Biochemical Systematics and Ecology2018, 81
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • Life Sci.2023, 317:121458.
  • Nutrients.2021, 13(10):3414.
  • Nutr Cancer.2022, 1-13.
  • J Ethnopharmacol.2022, 291:115159.
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • Int. J. of Food Properties2017, S108-S118
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • J Nat Med.2021, doi: 10.1007.
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • ...
  • 生物活性
    Description: Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxicity against four human tumor cell lines, HL-60, SMMC-7712, A-549, and MCF-7, in vitro.
    Targets: Histamine Receptor | Antifection
    In vitro:
    J Nat Prod. 2013 Jan 25;76(1):79-84.
    Meroterpenoid pigments from the basidiomycete Albatrellus ovinus.[Pubmed: 23305465]

    METHODS AND RESULTS:
    Eight grifolin derivatives, involving three new monomers, albatrelins A-C (1-3), three novel dimers (meroterpenoid pigments), albatrelins D-F (4-6), and two known ones, 6a,7,8,9,10,10a-hexahydro-3,6,9-trimethyl-6-(4-methyl-3-penten-1-yl)-1,9-epoxy-6H-dibenzo[b,d]pyran (7) and Confluentin (8), were isolated from Albatrellus ovinus. Their structures were established by extensive spectroscopic analysis. The absolute configurations of compounds 2-4 were determined as 9R by comparing their optical rotations with data reported in the literature.
    CONCLUSIONS:
    Albatrelin F (6) was isolated as a pair of C-2' tautomers with a ratio of 1.3:1. Confluentin (8) showed weak cytotoxicity against four human tumor cell lines, HL-60, SMMC-7712, A-549, and MCF-7, in vitro.
    Arch Pharm (Weinheim). 2003 Apr;336(2):119-26.
    Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product, confluentin.[Pubmed: 12761765]
    Several prenylphenols from basidiocarps of European and Chinese Albatrellus spp., namely grifolin (1), neogrifolin (2), Confluentin (3), scutigeral (4), and albaconol (5) were investigated concerning their activities in test models for vanilloid receptor modulation.
    METHODS AND RESULTS:
    The isolation of these compounds from A. confluens and structure elucidation of the novel natural product Confluentin (3) are described. The effects of scutigeral and neogrifolin on vanilloid receptors were studied by means of electrophysiological methodology on rat dorsal root ganglion neurons as well as on recombinant cell lines expressing the rat VR1 receptor. Concurrently, the effects of compounds 1-5 on a reporter cell line expressing the human vanilloid receptor VR1 were measured.
    CONCLUSIONS:
    In contrast to previous studies reported in the literature, the results of these investigations suggest that fungal prenylphenols act as weak antagonists (activity in the microM range), rather than exhibiting agonistic activities.
    Planta Med. 2010 Feb;76(2):182-5.
    Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis.[Pubmed: 19644795]

    METHODS AND RESULTS:
    Antibacterial bioassay-guided fractionation of two American mushroom species, Jahnoporus hirtus and Albatrellus flettii, led to the isolation and identification of their major antibacterial constituents: 3,11-dioxolanosta-8,24( Z)-diene-26-oic acid (1) from J. hirtus and Confluentin (2), grifolin (3), and neogrifolin (4) from A. flettii. Compound 1 is a new lanostane-type triterpene. All purified compounds were evaluated for their ability to inhibit the growth of Bacillus cereus and Enterococcus faecalis using standard MIC assays. Compounds 1- 4 demonstrated MIC values of 40, 20, 10, and 20 microg/mL, respectively, against B. cereus and MIC values of 32, 1.0, 0.5, and 0.5 microg/mL, respectively, against E. faecalis.
    CONCLUSIONS:
    Thus, one novel compound and three others were shown to possess antimicrobial activities against these gram-positive bacteria employed as surrogates for more virulent and dangerous pathogens.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0628 mL 15.3139 mL 30.6279 mL 61.2557 mL 76.5697 mL
    5 mM 0.6126 mL 3.0628 mL 6.1256 mL 12.2511 mL 15.3139 mL
    10 mM 0.3063 mL 1.5314 mL 3.0628 mL 6.1256 mL 7.657 mL
    50 mM 0.0613 mL 0.3063 mL 0.6126 mL 1.2251 mL 1.5314 mL
    100 mM 0.0306 mL 0.1531 mL 0.3063 mL 0.6126 mL 0.7657 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (+)-gamma-生育酚; (+)-gamma-Tocopherol CFN91685 54-28-4 C28H48O2 = 416.7 5mg QQ客服:2056216494
    Gamma-生育三烯酚; Gamma-Tocotrienol CFN92817 14101-61-2 C28H42O2 = 410.6 5mg QQ客服:2159513211
    Alpha-生育三烯酚; Alpha-Tocotrienol CFN92821 1721-51-3 C29H44O2 = 424.7 5mg QQ客服:2159513211
    天然维生素E; DL-alpha-Tocopherol CFN90041 59-02-9 C29H50O2 = 430.7 20mg QQ客服:1413575084
    α-生育酚醋酸酯; alpha-Tocopherol acetate CFN98999 58-95-7 C31H52O3 = 472.8 20mg QQ客服:2056216494
    去羟基-Delta-生育酚,2,8-二甲基-2-(4,8,12-三甲基十三烷基)-2H-1-苯并吡喃-6-醇; Dehydro-Delta-tocopherol CFN97674 802909-72-4 C27H44O2 = 400.65 5mg QQ客服:2056216494
    (+)-Delta-生育酚; (+)-Delta-Tocopherol CFN91145 119-13-1 C27H46O2 = 402.7 5mg QQ客服:2159513211
    Confluentin; Confluentin CFN98991 585534-03-8 C22H30O2 = 326.5 5mg QQ客服:2056216494
    Daurichromenic acid; Daurichromenic acid CFN97302 82003-90-5 C23H30O4 = 370.5 5mg QQ客服:215959384
    Beta-生育三烯酚; Beta-Tocotrienol CFN92822 490-23-3 C28H42O2 = 410.6 5mg QQ客服:3257982914

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