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  • 甲基条叶蓟素; 泽兰黄素

    Cirsilineol

    甲基条叶蓟素; 泽兰黄素
    产品编号 CFN90418
    CAS编号 41365-32-6
    分子式 = 分子量 C18H16O7 = 344.32
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Artemisia capillaries
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甲基条叶蓟素; 泽兰黄素 CFN90418 41365-32-6 1mg QQ客服:2056216494
    甲基条叶蓟素; 泽兰黄素 CFN90418 41365-32-6 5mg QQ客服:2056216494
    甲基条叶蓟素; 泽兰黄素 CFN90418 41365-32-6 10mg QQ客服:2056216494
    甲基条叶蓟素; 泽兰黄素 CFN90418 41365-32-6 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Stirling (United Kingdom)
  • Melbourne University (Australia)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Shanghai Institute of Organic Chemistry (China)
  • Calcutta University (India)
  • National Cancer Institute (USA)
  • Julius Kühn-Institut (Germany)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Griffith University (Australia)
  • University of Zurich (Switzerland)
  • University of Medicine and Pharmacy (Romania)
  • University of Eastern Finland (Finland)
  • University of Hull (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • National University of Pharmacy2022, 1:73-76
  • Environ Toxicol.2020, doi: 10.1002
  • Int J Mol Sci.2015, 16(1):1232-51
  • Phytother Res.2015, 29(7):1088-96
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Int J Mol Sci.2021, 22(8):4211.
  • Anal Biochem.2019, 569:10-15
  • Integr Med Res.2017, 6(4):395-403
  • Int J Mol Med.2016, 37(2):501-8
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • J Food Biochem.2020, 44(6):e13198.
  • PLoS One.2020, 15(2):e0220084.
  • Arch Biochem Biophys.2018, 644:93-99
  • J Ethnopharmacol.2017, 206:327-336
  • Int J Mol Sci.2019, 20(16):E4015
  • Pharmaceutics.2022, 14(12):2765.
  • Appl. Sci.2021, 11(24),12080
  • Journal of Life Science2018, 917-922
  • Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
  • Food Res Int.2022, 157:111207.
  • Molecules2022, 27(9):2827.
  • Int Immunopharmacol.2022, 106:108603.
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • ...
  • 生物活性
    Description: Cirsilineol may be potentially useful for treating T-cell-mediated human inflammatory bowel diseases. Cirsilineol alsio has anti-proliferative activity against cancer cells by the induction of apoptosis via the mitochondrial pathway.
    Targets: IFN-γ | IL Receptor | gp120/CD4 | STAT | TGF-β/Smad | JAK | PARP | Caspase | P450 (e.g. CYP17)
    In vitro:
    Biochem Pharmacol. 2010 Jan 15;79(2):229-38.
    Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease.[Pubmed: 19698701]
    Regulation of signal transducer and activator of transcription (STAT) 1 signaling is being explored as a new approach to the treatment of inflammatory bowel diseases. However, few chemicals have been reported to inhibit IFN-gamma/STAT1 signaling for Crohn's disease therapy.
    METHODS AND RESULTS:
    In the present study, we found that Cirsilineol, a small natural compound isolated from Artemisia vestita, significantly ameliorated trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice, which was closely associated with reduced autoreactive T-cell proliferation and activation. Moreover, the regulatory action of pro-inflammatory and anti-inflammatory cytokine by Cirsilineol treatment was found to decrease the activity of effector Th1 cells but increase the activity of regulatory T cells as characterized by down-regulation of IFN-gamma and corresponding up-regulation of IL-10 and TGF-beta. The therapeutic effect of Cirsilineol was attributable to a novel regulatory mechanism with selective inhibiting IFN-gamma signaling in colonic lamina propria CD4(+) T cells, which was mediated through down-regulating STAT1 activation and T-bet expression. Furthermore, Cirsilineol was found to down-regulate the activation of JAK2, a critical kinase for IFN-gamma/STAT1 signaling, and abrogate the expression of T-bet, resulting in markedly decreased proliferation and activation of T cells in vitro. Importantly, the inhibition of IFN-gamma/STAT1 signaling by Cirsilineol was reversible in the presence of high level of IFN-gamma.
    CONCLUSIONS:
    These results strongly suggest that Cirsilineol might be potentially useful for treating T-cell-mediated human inflammatory bowel diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9043 mL 14.5214 mL 29.0428 mL 58.0855 mL 72.6069 mL
    5 mM 0.5809 mL 2.9043 mL 5.8086 mL 11.6171 mL 14.5214 mL
    10 mM 0.2904 mL 1.4521 mL 2.9043 mL 5.8086 mL 7.2607 mL
    50 mM 0.0581 mL 0.2904 mL 0.5809 mL 1.1617 mL 1.4521 mL
    100 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5809 mL 0.7261 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,3',4',5,6,7,8-七甲氧基黄酮; 3,3',4',5,6,7,8-heptamethoxyflavone CFN95021 1178-24-1 C22H24O9 = 432.4 10mg QQ客服:1413575084
    4'-甲氧基黄酮; 4'-Methoxyflavone CFN70361 4143-74-2 C16H12O3 = 252.3 5mg QQ客服:215959384
    7-羟基-4'-甲氧基黄酮; 7-Hydroxy-4'-methoxyflavone CFN70378 487-24-1 C16H12O4 = 268.3 5mg QQ客服:1413575084
    3',4'-二羟基黄酮; 3',4'-Dihydroxyflavone CFN70360 4143-64-0 C15H10O4 = 254.2 20mg QQ客服:2056216494
    3',4'-二甲氧基黄酮; 3',4'-Dimethoxyflavone CFN70359 4143-62-8 C17H14O4 = 282.3 20mg QQ客服:215959384
    3',4',7-三羟基黄酮; 7,3',4'-Trihydroxyflavone CFN97786 2150-11-0 C15H10O5 = 270.24 20mg QQ客服:2056216494
    3',4',7,8-四羟基黄酮; 3',4',7,8-Tetrahydroxyflavone CFN70342 3440-24-2 C15H10O6 = 286.2 5mg QQ客服:2056216494
    木犀草素; 3',4',5,7-四羟基黄酮; Luteolin CFN98784 491-70-3 C15H10O6 = 286.2 20mg QQ客服:1413575084
    羟基芫花素; Hydroxygenkwanin CFN98021 20243-59-8 C16H12O6 = 300.3 20mg QQ客服:215959384
    5,7-二甲氧基木犀草素; 5,7-Dimethoxyluteolin CFN91001 N/A C17H14O6 = 314.3 10mg QQ客服:1457312923

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