甲基条叶蓟素; 泽兰黄素

Cirsilineol

	产品编号	CFN90418
	CAS编号	41365-32-6
	分子式 = 分子量	C₁₈H₁₆O₇ = 344.32
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The herbs of Artemisia capillaries
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
甲基条叶蓟素; 泽兰黄素	CFN90418	41365-32-6	1mg	QQ客服：1413575084
甲基条叶蓟素; 泽兰黄素	CFN90418	41365-32-6	5mg	QQ客服：1413575084
甲基条叶蓟素; 泽兰黄素	CFN90418	41365-32-6	10mg	QQ客服：1413575084
甲基条叶蓟素; 泽兰黄素	CFN90418	41365-32-6	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Amsterdam (Netherlands)

Florida A&M University (USA)

Universidad de Ciencias y Artes de Chiapas (Mexico)

Wroclaw Medical University (Poland)

Kyoto University (Japan)

Shanghai Institute of Biochemistry and Cell Biology (China)

University of Malaya (Malaysia)

Sant Gadge Baba Amravati University (India)

Johannes Gutenberg University Mainz (JGU) (Germany)

Tohoku University (Japan)

Worcester Polytechnic Institute (USA)

Mendel University in Brno (Czech Republic)

Universidad de Antioquia (Colombia)

University of Limpopo (South Africa)

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Description:

Cirsilineol may be potentially useful for treating T-cell-mediated human inflammatory bowel diseases. Cirsilineol alsio has anti-proliferative activity against cancer cells by the induction of apoptosis via the mitochondrial pathway.

Targets:

In vitro:

Biochem Pharmacol. 2010 Jan 15;79(2):229-38.

Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease.[Pubmed: 19698701]

Regulation of signal transducer and activator of transcription (STAT) 1 signaling is being explored as a new approach to the treatment of inflammatory bowel diseases. However, few chemicals have been reported to inhibit IFN-gamma/STAT1 signaling for Crohn's disease therapy.
METHODS AND RESULTS:
In the present study, we found that Cirsilineol, a small natural compound isolated from Artemisia vestita, significantly ameliorated trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice, which was closely associated with reduced autoreactive T-cell proliferation and activation. Moreover, the regulatory action of pro-inflammatory and anti-inflammatory cytokine by Cirsilineol treatment was found to decrease the activity of effector Th1 cells but increase the activity of regulatory T cells as characterized by down-regulation of IFN-gamma and corresponding up-regulation of IL-10 and TGF-beta. The therapeutic effect of Cirsilineol was attributable to a novel regulatory mechanism with selective inhibiting IFN-gamma signaling in colonic lamina propria CD4(+) T cells, which was mediated through down-regulating STAT1 activation and T-bet expression. Furthermore, Cirsilineol was found to down-regulate the activation of JAK2, a critical kinase for IFN-gamma/STAT1 signaling, and abrogate the expression of T-bet, resulting in markedly decreased proliferation and activation of T cells in vitro. Importantly, the inhibition of IFN-gamma/STAT1 signaling by Cirsilineol was reversible in the presence of high level of IFN-gamma.
CONCLUSIONS:
These results strongly suggest that Cirsilineol might be potentially useful for treating T-cell-mediated human inflammatory bowel diseases.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
川陈皮素；蜜橘黄素；川皮亭; Nobiletin	CFN98726	478-01-3	C₂₁H₂₂O₈ = 402.4	20mg	QQ客服：2056216494
3,5,6,7,8,4'-六甲氧基黄酮; 3,5,6,7,8,4'-hexamethoxyflavone	CFN91805	34170-18-8	C₂₁H₂₂O₈ = 402.4	5mg	QQ客服：1457312923
3,3',4',5,6,7,8-七甲氧基黄酮; 3,3',4',5,6,7,8-heptamethoxyflavone	CFN95021	1178-24-1	C₂₂H₂₄O₉ = 432.4	10mg	QQ客服：2056216494
4'-羟基黄烷酮; 4'-Hydroxyflavone	CFN91544	4143-63-9	C₁₅H₁₀O₃ = 238.2	20mg	QQ客服：1457312923
4'-甲氧基黄酮; 4'-Methoxyflavone	CFN70361	4143-74-2	C₁₆H₁₂O₃ = 252.3	5mg	QQ客服：1457312923
7-羟基-4'-甲氧基黄酮; 7-Hydroxy-4'-methoxyflavone	CFN70378	487-24-1	C₁₆H₁₂O₄ = 268.3	5mg	QQ客服：2056216494
3',4'-二羟基黄酮; 3',4'-Dihydroxyflavone	CFN70360	4143-64-0	C₁₅H₁₀O₄ = 254.2	20mg	QQ客服：2159513211
3',4'-二甲氧基黄酮; 3',4'-Dimethoxyflavone	CFN70359	4143-62-8	C₁₇H₁₄O₄ = 282.3	20mg	QQ客服：2159513211
3',4',7-三羟基黄酮; 7,3',4'-Trihydroxyflavone	CFN97786	2150-11-0	C₁₅H₁₀O₅ = 270.24	20mg	QQ客服：1457312923
3',4',7,8-四羟基黄酮; 3',4',7,8-Tetrahydroxyflavone	CFN70342	3440-24-2	C₁₅H₁₀O₆ = 286.2	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9043 mL	14.5214 mL	29.0428 mL	58.0855 mL	72.6069 mL
5 mM	0.5809 mL	2.9043 mL	5.8086 mL	11.6171 mL	14.5214 mL
10 mM	0.2904 mL	1.4521 mL	2.9043 mL	5.8086 mL	7.2607 mL
50 mM	0.0581 mL	0.2904 mL	0.5809 mL	1.1617 mL	1.4521 mL
100 mM	0.029 mL	0.1452 mL	0.2904 mL	0.5809 mL	0.7261 mL