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  • 3'-羟基-5,7,4'-三甲氧基黄酮

    3'-Hydroxy-5,7,4'-trimethoxyflavone

    3'-羟基-5,7,4'-三甲氧基黄酮
    产品编号 CFN95396
    CAS编号 33554-52-8
    分子式 = 分子量 C18H16O6 = 328.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Callicarpa bodinieri
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3'-羟基-5,7,4'-三甲氧基黄酮 CFN95396 33554-52-8 1mg QQ客服:215959384
    3'-羟基-5,7,4'-三甲氧基黄酮 CFN95396 33554-52-8 5mg QQ客服:215959384
    3'-羟基-5,7,4'-三甲氧基黄酮 CFN95396 33554-52-8 10mg QQ客服:215959384
    3'-羟基-5,7,4'-三甲氧基黄酮 CFN95396 33554-52-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Industrial de Santander (Colombia)
  • University of Otago (New Zealand)
  • University of Hertfordshire (United Kingdom)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Siksha O Anusandhan University (India)
  • University of Eastern Finland (Finland)
  • University of Illinois at Chicago (USA)
  • Aarhus University (Denmark)
  • The Australian National University (Australia)
  • Univerzita Karlova v Praze (Czech Republic)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Universidad Veracuzana (Mexico)
  • Wroclaw Medical University (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Commun.2019, 10(1):5169
  • Molecules.2020, 25(15):3353.
  • J Cell Physiol.2020, 10.1002
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • J Drug Target.2016, 24:1-28
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • J AOAC Int.2021, 104(6):1634-1651.
  • South African Journal of Botany2021, 142:114-123.
  • LWT-Food Science and Technology2017, 75:488-496
  • Sci Rep.2020, 10:4495(2020)
  • Korean J of Crop Science2019, 452-458
  • Front Immunol. 2020, 11:62.
  • Plants (Basel).2021, 10(4):702.
  • Phytother Res.2022, 35844057.
  • Microb Pathog.2019, 131:128-134
  • Pharmaceuticals (Basel).2021, 14(10):1046.
  • J Food Biochem.2019, 43(9):e12970
  • Cell.2018, 172(1-2):249-261
  • Nutrients.2021, 13(3):978.
  • Mol Med Rep.2022, 25(1):8.
  • Exp Parasitol.2017, 183:160-166
  • Food Chemistry: X.2022, 2022.100270
  • Antioxidants (Basel).2020, 9(11):1121.
  • ...
  • 生物活性
    Description: 3'-Hydroxy-5,7,4'-trimethoxyflavone posseses antioxidant and immunomodulatory effects.3'-Hydroxy-5,7,4'-trimethoxyflavone has hypoglycemic activities, and showed significant PTP1B inhibitory activities with IC₅₀ values of 1.85 μmol•L⁻1.
    In vitro:
    J Pharm Pharmacol . 2015 Apr;67(4):597-604.
    Zeyheria montana Mart. (Bignoniaceae) as source of antioxidant and immunomodulatory compounds with beneficial effects on intestinal inflammation[Pubmed: 25556766]
    Objectives: Zeyheria montana is a medicinal plant used in Brazilian folk medicine for treating skin affections, ulcers, inflammation and diarrhoea, and as an antisyphilitic and antiblenorrhagic agent, but little is known about its mechanisms of action. Herein, a bio-guided assay was carried out to further evaluate its antioxidant and immunomodulatory effects, and the possible benefits on experimental intestinal inflammation. Methods: Extracts, partitions, fractions and isolated compounds were tested for inhibition of lipid peroxidation. Isolated compounds were tested in vitro for its antioxidant and immunomodulatory action prior to in-vivo evaluation in trinitrobenzenesulfonic acid-induced rat colitis. Key findings: Two major compounds were identified in the leaf dichloromethane extract: 3'-hydroxy-5,7,4'-trimethoxyflavone and 6-hydroxy-5,7-dimethoxyflavone, which exhibited an antioxidant activity. The compounds protected the colonic glutathione levels in more than 90% despite the absence of protection against the gross macroscopic colonic damage. In addition, the compounds inhibited IL-1ß secretion by macrophages in 91.5% and 72.7% respectively, whereas both reduced IL-6 secretion in about 44.5%. Conclusions: The major active compounds from Z. montana leaves exerted antioxidant and immunomodulatory effects, endorsing the use of Z. montana in folk medicine as an anti-inflammatory agent. However, further investigation is still needed regarding medicinal plants and the identification of candidate compounds for the treatment of the inflammatory bowel diseases.
    Zhongguo Zhong Yao Za Zhi . 2016 Mar;41(5):868-873.
    [Studies on flavonoids from Cirsium setosum][Pubmed: 28875641]
    To investigate the chemical constituents of ethyl acetate from Cirsium setosum, fifteen flavonoids were obtained by column chromatography on silica gel, MCI, Sephadex LH-20, and preparative HPLC. Their structures were identified as 4',5,6-trihydroxy-7-methoxyflavone(1), 4',5-dihydroxy-7,8-dimethoxyflavone(2), sorbifolin-6-O-β-glucopyranoside(3), kaempferol-7-O-α-L-rhamnoside(4), kaempferol(5), quercetin-3-O-β-D-glucosyl-7-O-α-L-rhamnoside(6), myricetin(7), myricetin-3-O-β-D-glucoside(8), 5,7- dihydroxy -3',4'- dimethoxyflavone(9), 3',4',5- trihydroxy-3,7-dimethoxyflavone(10), 3',3,4',5-tetrahydroxy-7-methoxyflavone(11), 3'-hydroxy-4',5,7-trimethoxyflavone(12), 7-hydroxy-3',4',5-trimethoxyflavone(13), 4',5-dihydroxy-2',3',7,8-tetramethoxylflavone(14), and 5-hydroxy-2',3',7,8-tetramethoxylflavone(15) by spectroscopic data analysis. All compounds were isolated from this plant for the first time.Compounds(1-15) were evaluated for their hypoglycemic activities by PTP1B enzyme model. Among them, compounds 2, 12, and 14 showed significant PTP1B inhibitory activities with IC₅₀ values of 2.54, 1.85, 2.11 μmol•L⁻1, respectively.
    Phytochemistry . 2001 May;57(1):57-64.
    Insecticidal flavaglines and other compounds from Fijian Aglaia species[Pubmed: 11336261]
    Bioassays with lipophilic crude extracts of four Fijian Aglaia species against Spodoptera littoralis displayed strong insecticidal activity for A. basiphylla and A. gracilis, whereas A. archboldiana and A. vitiensis did not have any significant effects. The insect toxicity of A. basiphylla was caused by the well known benzofuran flavaglines rocaglamide, desmethylrocaglamide and aglafoline. In contrast, A. gracilis contained four related pyrimidinone derivatives in the root and stem bark, including two new congeners named marikarin and 3'-hydroxymarikarin. Moreover, two new putrescine bisamides, secoodorine and secopiriferine, a new benzopyran flavagline. desacetylaglain A. and a new norsesquiterpene were isolated from the leaves together with three known bisamides and 3-hydroxy-5,7,4'-trimethoxyflavone. The structures of the new compounds were elucidated by spectroscopic methods. Comparative feeding assays within the active pyrimidinone flavaglines showed that the free hydroxy group in aromatic ring A of marikarin diminishes insecticidal activity.
    Biochem Res Int . 2020 Feb 18;2020:4812312.
    Methylated Flavonols from Amomum koenigii J.F.Gmel. and Their Antimicrobial and Antioxidant Activities[Pubmed: 32148963]
    Methylated flavonols form a special group with modulating biological activities in comparison with kaempferol and quercetin. The present study isolated ten compounds including two kaempferol methyl ethers: 5-hydroxy-3,7,4'-trimethoxyflavone (1), 3-hydroxy-5,7,4'-trimethoxyflavone (6); four quercetin methyl ethers: retusin (5-hydroxy-3,7,3',4'-tetramethoxyflavone) (4), 3,5-dihydroxy-7,3',4'-trimethoxyflavone (5), 3,4'-dihydroxy-5,7,3'-trimethoxyflavone (7), and 3,5,7,3',4'-pentamethoxyflavone (9); β-sitosterol (2); 5-hydroxy-1-(4'-hydroxyphenyl)eicosan-3-one (3); p-hydroquinone (8); and vanillic acid (10) from the rhizomes and fruit of Amomum koenigii J.F.Gmel. (Zingiberaceae). Their structures were determined by MS, NMR, and X-ray spectroscopic techniques. Among the methylated flavonols, 1, 4-7, and 9 were isolated for the first time from the rhizomes, while 1, 4, and 5 were isolated from the fruit. Compounds 2, 3, 7, 8, and 10 were reported for the first time from the species. Three main methylated flavonols 1, 4, and 5 were quantitatively analyzed in the rhizomes of A. koenigii by RP-HPLC-DAD; their contents were determined to be 1.81% (1), 1.38% (4), and 1.76% (5). The antimicrobial assay against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Aspergillus niger, Fusarium oxysporum, Candida albicans, and Saccharomyces cerevisiae and antioxidant DPPH scavenging test were performed for the isolated methylated flavonols.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.046 mL 15.23 mL 30.4599 mL 60.9199 mL 76.1499 mL
    5 mM 0.6092 mL 3.046 mL 6.092 mL 12.184 mL 15.23 mL
    10 mM 0.3046 mL 1.523 mL 3.046 mL 6.092 mL 7.615 mL
    50 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.2184 mL 1.523 mL
    100 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.6092 mL 0.7615 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    半齿泽兰素; Eupatorin CFN97418 855-96-9 C18H16O7 = 344.3 10mg QQ客服:2056216494
    半齿泽兰素-5-甲醚; Eupatorin-5-methylether CFN70313 21764-09-0 C19H18O7 = 358.4 5mg QQ客服:1457312923
    金圣草(黄)素; Chrysoeriol CFN98785 491-71-4 C16H12O6 = 300.3 5mg QQ客服:1457312923
    4 '-甲基金圣草素; 4'-Methylchrysoeriol CFN91826 4712-12-3 C17H14O6 = 314.3 5mg QQ客服:2159513211
    毡毛美洲茶素; Velutin CFN98290 25739-41-7 C17H14O6 = 314.3 5mg QQ客服:1457312923
    4'-Hydroxy-5,7,3'-trimethoxyflavone; 4'-Hydroxy-5,7,3'-trimethoxyflavone CFN95398 1239-68-5 C18H16O6 = 328.3 5mg QQ客服:1457312923
    棕矢车菊素; Jaceosidin CFN90386 18085-97-7 C17H14O7 = 330.29 20mg QQ客服:2056216494
    甲基条叶蓟素; 泽兰黄素; Cirsilineol CFN90418 41365-32-6 C18H16O7 = 344.32 5mg QQ客服:2159513211
    棉花素 3,3',8-三甲醚; Gossypetin 3,3',8-trimethylether CFN70278 14965-08-3 C18H16O8 = 360.3 5mg QQ客服:3257982914
    4',5,8-三羟基-3',6,7-三甲氧基黄酮; Isothymonin CFN92436 99615-01-7 C18H16O8 = 360.3 5mg QQ客服:2159513211

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