Calyxin B
Calyxin B
|
|
产品编号 |
CFN99693 |
| CAS编号 |
164991-53-1 |
| 分子式 = 分子量 |
C35H34O8 = 582.7 |
| 产品纯度 |
>=98% |
| 物理属性 |
Yellow powder |
| 化合物类型 |
Chalcones |
| 植物来源 |
The herbs of Alpinia galanga |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| Calyxin B |
CFN99693 |
164991-53-1 |
1mg |
QQ客服：215959384 |
| Calyxin B |
CFN99693 |
164991-53-1 |
5mg |
QQ客服：215959384 |
| Calyxin B |
CFN99693 |
164991-53-1 |
10mg |
QQ客服：215959384 |
| Calyxin B |
CFN99693 |
164991-53-1 |
20mg |
QQ客服：215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
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Universiti Sains Malaysia (Malaysia)
Worcester Polytechnic Institute (USA)
Universiti Putra Malaysia(UPM) (Malaysia)
University of Pretoria (South Africa)
Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
Universiti Kebangsaan Malaysia (Malaysia)
University of Toulouse (France)
Istanbul University (Turkey)
Vin?a Institute of Nuclear Sciences (Serbia)
Griffith University (Australia)
Institute of Tropical Disease Universitas Airlangga (Indonesia)
Korea Intitute of Science and Technology (KIST) (Korea)
Universidade Católica Portuguesa (Portugal)
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Calyxin B exhibits potent activity against human HT-1080 fibrosarcoma cells with an ED50 value of 0.69 microM. A methylated product of calyxin A and an epimeric mixture of Calyxin B, showed greatly reduced activity suggesting that phenolic hydroxyl groups are involved in the inhibitory activity. |
| Targets: |
NO |
| In vitro: |
| Biol Pharm Bull. 1998 Apr;21(4):371-4. | | Inhibitory effect of diarylheptanoids on nitric oxide production in activated murine macrophages.[Pubmed: 9586575] |
METHODS AND RESULTS:
Thirteen novel diarylheptanoids bearing a chalcone or a flavanone moiety (1-13), a new curcumin derivative, 1,2-dihydrobis(de-O-methyl)curcumin (14), and two known flavonoids (15 and 16) isolated from the seeds of Alpinia blepharocalyx K. Schum. were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccaride (LPS)-activated murine macrophages J774.1 in vitro. All the tested compounds inhibited NO production in a concentration-dependent manner (IC50=36-568 microM). Among the compounds examined, blepharoCalyxin B (13) was the most potent inhibitor of NO production (IC50=36 microM).
CONCLUSIONS:
Analysis of the structure activity relationship among these novel diarylheptanoids led to the conclusion that the position of attachment of a chalcone or a flavanone to a diarylheptanoid does not affect their inhibitory potency although their presence in association causes a substantial enhancement of the inhibitory activity. Moreover, a conjugated double bond in a chalcone moiety potentiated the inhibitory activity. On the other hand, hexamethoxydeoxycalyxin A (17) and pentamethoxyCalyxin B (18), a methylated product of calyxin A (1) and an epimeric mixture of Calyxin B, showed greatly reduced activity suggesting that phenolic hydroxyl groups are involved in the inhibitory activity. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.7161 mL |
8.5807 mL |
17.1615 mL |
34.323 mL |
42.9037 mL |
| 5 mM |
0.3432 mL |
1.7161 mL |
3.4323 mL |
6.8646 mL |
8.5807 mL |
| 10 mM |
0.1716 mL |
0.8581 mL |
1.7161 mL |
3.4323 mL |
4.2904 mL |
| 50 mM |
0.0343 mL |
0.1716 mL |
0.3432 mL |
0.6865 mL |
0.8581 mL |
| 100 mM |
0.0172 mL |
0.0858 mL |
0.1716 mL |
0.3432 mL |
0.429 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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