Info: Read More
  • 中药标准品生产商,产品定制服务
  • 毛蕊异黄酮

    Calycosin

    毛蕊异黄酮
    产品编号 CFN99140
    CAS编号 20575-57-9
    分子式 = 分子量 C16H12O5 = 284.26
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Astragalus membranaceus Bge. var. mongholicus.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    毛蕊异黄酮 CFN99140 20575-57-9 10mg QQ客服:215959384
    毛蕊异黄酮 CFN99140 20575-57-9 20mg QQ客服:215959384
    毛蕊异黄酮 CFN99140 20575-57-9 50mg QQ客服:215959384
    毛蕊异黄酮 CFN99140 20575-57-9 100mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medizinische Universit?t Wien (Austria)
  • Universidad Industrial de Santander (Colombia)
  • Complutense University of Madrid (Spain)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University of Ioannina (Greece)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Sant Gadge Baba Amravati University (India)
  • University of Fribourg (Switzerland)
  • St. Jude Children Research Hospital (USA)
  • Universidade de Franca (Brazil)
  • Lodz University of Technology (Poland)
  • University of Queensland (Australia)
  • National Hellenic Research Foundation (Greece)
  • Kamphaengphet Rajabhat University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Pharmaceut Biomed2020, 178:112894
  • Aquaculture2019, 510:392-399
  • Int. J. Mol. Sci.2022, 23(19), 11900.
  • Antioxidants (Basel).2022, 11(10):1929.
  • Pharmaceuticals (Basel).2021, 14(8):742.
  • Plant Direct.2021, 5(12):e372.
  • Nutrients2023, 15(18), 4016.
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • J of Food Quality2020, 8851285.
  • Pharmacol Rep.2019, 71(2):289-298
  • PLoS One.2020, 15(2):e0220084.
  • Separation Science Plus2022, sscp.202200048.
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • Molecules.2021, 26(2):313.
  • Antioxidants (Basel).2022, 11(12):2327.
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Plant Archives2020, 2(1),2929-2934
  • J Ethnopharmacol.2017, 206:327-336
  • Biomolecules.2022, 12(12):1754.
  • J Cachexia Sarcopenia Muscle.2022, 13(6):3149-3162.
  • Preprints2022, 2022030063.
  • J Cell Mol Med . 2023, jcmm.17954.
  • Front Neurosci.2019, 13:1091
  • ...
  • 生物活性
    Description: Calycosin, a selective estrogen receptor modulator, is also a vasorelaxant and a noncompetitive Ca(2+) channel blocker. It has anti-oxidative, anti-inflammatory, hepatoprotective,antineoplastic, and effective skin-lightening activities. Calycosin exhibited tyrosinase inhibitory activity with an IC(50) value of 38.4 microM, it suppressed breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways.
    Targets: Bcl-2/Bax | Caspase | Akt | FXR | STAT | p38MAPK | ERK | JNK | PI3K | IGF-1R | Calcium Channel
    In vitro:
    Cell Physiol Biochem. 2015;35(2):722-8.
    Calycosin and Genistein Induce Apoptosis by Inactivation of HOTAIR/p-Akt Signaling Pathway in Human Breast Cancer MCF-7 Cells.[Pubmed: 25613518]
    Calycosin and genistein are the two main components of isoflavones. Previously, we reported that these compounds display antitumor activities in the breast cancer cell lines MCF-7 and T47D. In the present study, we investigated the mechanism of action of calycosin and genistein, and their respective efficacies as potential therapies for the treatment of breast carcinoma in the clinic.
    METHODS AND RESULTS:
    MCF-7 cells were treated with calycosin or genistein. Cell proliferation and apoptosis were measured using CCK8 assay and Hoechst 33258. The expression level of phosphorylated Akt protein was determined by western blotting. Expression level of HOTAIR was quantified by real-time PCR. Both calycosin and genistein inhibited proliferation and induced apoptosis in MCF-7 breast cancer cells, especially after treatment with calycosin. Treatment of MCF-7 cells with calycosin or genistein resulted in decreased phosphorylation of Akt, and decreased expression of its downstream target, HOTAIR.
    CONCLUSIONS:
    Calycosin is more effective in inhibiting breast cancer growth in comparison with genistein, through its regulation of Akt signaling pathways and HOTAIR expression.
    PLoS One. 2014 Mar 11;9(3):e91245.
    Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways.[Pubmed: 24618835]
    We previously reported that calycosin, a natural phytoestrogen structurally similar to estrogen, successfully triggered apoptosis of estrogen receptor (ER)-positive breast cancer cell line, MCF-7.
    METHODS AND RESULTS:
    To better understand the antitumor activities of calycosin against breast cancer, besides MCF-7 cells, another ER-positive cell line T-47D was analyzed here, with ER-negative cell lines (MDA-231, MDA-435) as control. Notably, calycosin led to inhibited cell proliferation and apoptosis only in ER-positive cells, particularly in MCF-7 cells, whereas no such effect was observed in ER-negative cells. Then we investigated whether regulation of ERβ, a subtype of ER, contributed to calycosin-induced apoptosis in breast cancer cells. The results showed that incubation of calycosin resulted in enhanced expression ERβ in MCF-7 and T-47D cells, rather than MDA-231 and MDA-435 cells. Moreover, with the upregulation of ERβ, successive changes in downstream signaling pathways were found, including inactivation of insulin-like growth factor 1 receptor (IGF-1R), then stimulation of p38 MAPK and suppression of the serine/threonine kinase (Akt), and finally poly(ADP-ribose) polymerase 1 (PARP-1) cleavage. However, the other two members of the mitogen-activated protein kinase (MAPK) family, extracellular signal-regulated kinase (ERK) 1/2 and c-Jun N-terminal kinase (JNK), were not consequently regulated by downregulated IGF-1R, indicating ERK 1/2 and JNK pathways were not necessary to allow proliferation inhibition by calycosin.
    CONCLUSIONS:
    Taken together, our results indicate that calycosin tends to inhibit growth and induce apoptosis in ER-positive breast cancer cells, which is mediated by ERβ-induced inhibition of IGF-1R, along with the selective regulation of MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt pathways.
    In vivo:
    J Neurol Sci. 2014 Apr 15;339(1-2):144-8.
    Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats.[Pubmed: 24548484 ]
    Isoflavone calycosin is a typical phytoestrogen extracted from Chinese medical herb Radix Astragali. It has been reported that estrogens could provide neuroprotective effects, and dietary intake of phytoestrogens could reduce stroke injury in cerebral ischemia/reperfusion (I/R) animal models.
    METHODS AND RESULTS:
    In the present study, we investigate the molecular mechanisms underlying the neuroprotective effects of calycosin on middle cerebral artery occlusion (MCAO) rats. Focal cerebral ischemia was induced in male rats by MCAO, neurological deficits and brain edema was evaluated after 24h of reperfusion. The results shown calycosin significantly reduced the infarcted volume and the brain water content, and improved the neurological deficit. To provide insight into the functions of estrogen receptor (ER)-mediated signaling pathway in neuroprotection by calycosin, the expression of miR-375, ER-α, RASD1 (Dexamethasone-induced Ras-related protein 1) and Bcl-2 was determined by RT-PCR or western blot assay. Calycosin exhibited a downregulation of RASD1, and an upregulation of ER-α, miR-375 and Bcl-2.
    CONCLUSIONS:
    Our finding illustrated that calycosin had been shown neuroprotective effects in cerebral ischemia/reperfusion rats, and the molecular mechanisms may correlate with the positive feedback between ER-α and miR-375, along with the regulation of downstream targets.
    Acta Pharmacol. Sin., 2006, 27(8):1007–12.
    Calcium channel blocking activity of calycosin, a major active component of Astragali Radix, on rat aorta.[Pubmed: 16867251]
    To investigate the vasoactivity of calycosin, a major active component of Astragali Radix.
    METHODS AND RESULTS:
    Experiments were performed on isolated rat thoracic aortic rings pre-contracted with phenylephrine (PHE) or KCl. Calycosin produced a concentration-dependent relaxation on the tissue pre-contracted using PHE with 4.46+/-0.13 of pD(2) and 95.85%+/-2.67% of E(max); or using KCl with 4.27+/-0.05 of pD2 and 99.06%+/-2.15% of Emax, and displaced downwards the concentration-response curves of aortic rings to PHE or KCl. The relaxant effect of calycosin on denuded endothelium aortic rings was the same as on intact endothelium aortic rings, and its vasorelaxant effect was not influenced by L-NAME or indomethacin. In Ca(2+)-free solution, calycosin (30 micromol/L) did not have an effect on PHE (1 micromol/L)-induced aortic ring contraction. The effects of calycosin and nifedipine where somewhat different; calycosin decreased aortic ring contractions induced by the two agonists, but nifedipine displayed a more potent inhibitory effect on KCl-induced contractions than on PHE-induced contractions, and the vascular relaxing effects of calycosin and nifidipine were additive on PHE-induced contraction but not KCl-induced.
    CONCLUSIONS:
    Calycosin is a vasorelaxant. Its action is endothelium-independent and is unrelated to intracellular Ca(2+) release. It is a noncompetitive Ca(2+) channel blocker. The effect of calycosin on Ca(2+) channel blockade may be different from that of dihydropyridines. This study demonstrated a novel pharmacological activity of calycosin, and supplied a theoretic foundation for Astragali Radix application.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5179 mL 17.5895 mL 35.1791 mL 70.3581 mL 87.9477 mL
    5 mM 0.7036 mL 3.5179 mL 7.0358 mL 14.0716 mL 17.5895 mL
    10 mM 0.3518 mL 1.759 mL 3.5179 mL 7.0358 mL 8.7948 mL
    50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.4072 mL 1.759 mL
    100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.7036 mL 0.8795 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3'-甲氧基大豆黄素; 3'-Methoxydaidzein CFN96186 21913-98-4 C16H12O5 = 284.3 5mg QQ客服:1413575084
    3',4',5,7-四羟基异黄酮; Orobol CFN98737 480-23-9 C15H10O6 = 286.2 5mg QQ客服:1413575084
    3'-O-甲基香豌豆苷元; 3'-O-Methylorobol CFN98492 36190-95-1 C16H12O6 = 300.3 5mg QQ客服:2159513211
    7,3'-二-O-甲基奥洛波尔; 7,3'-Di-O-methylorobol CFN96518 104668-88-4 C17H14O6 = 314.30 5mg QQ客服:3257982914
    红车轴草素; Pratensein CFN90805 2284-31-3 C16H12O6 = 300.3 5mg QQ客服:2056216494
    5-Hydroxypseudobaptigenin; 5-Hydroxypseudobaptigenin CFN91501 40624-03-1 C16H10O6 = 298.3 5mg QQ客服:1413575084
    刺桐素 H; Erythrinin H CFN96559 1616592-62-1 C17H12O7 = 328.28 5mg QQ客服:215959384
    次野鸢尾黄素; Irisflorentin CFN99788 41743-73-1 C20H18O8 = 386.35 20mg QQ客服:215959384
    野鸢尾黄素; Irigenin CFN93276 548-76-5 C18H16O8 = 360.31 20mg QQ客服:2056216494
    Isolupalbigenin; Isolupalbigenin CFN96522 162616-70-8 C25H26O5 = 406.48 5mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产