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  • 鸦胆亭醇

    Bruceantinol A

    鸦胆亭醇
    产品编号 CFN91971
    CAS编号 948038-36-6
    分子式 = 分子量 C29H36O13 = 592.59
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The fruits of Brucea javanica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鸦胆亭醇 CFN91971 948038-36-6 1mg QQ客服:215959384
    鸦胆亭醇 CFN91971 948038-36-6 5mg QQ客服:215959384
    鸦胆亭醇 CFN91971 948038-36-6 10mg QQ客服:215959384
    鸦胆亭醇 CFN91971 948038-36-6 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heidelberg University (Germany)
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  • Cornell University (USA)
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  • Max Rubner-Institut (MRI) (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Applied Biological Chemistry2023, 66(58):112.
  • Processes2022, 10(10), 2008.
  • Preprints2022, 2022030063.
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Food Chem.2020, 327:126992.
  • Journal of Functional Foods2017, 30:30-38
  • FASEB J.2019, 33(8):9685-9694
  • Molecules2021, 26(1),230
  • Environ Toxicol.2019, 34(4):513-520.
  • Horticulturae2023, 9(2), 213.
  • Food Funct.2021, 12(13):5892-5902.
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Chem Biol Interact.2019, 315:108910
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
  • J Nat Prod.2018, 81(4):966-975
  • Food Chem.2019, 274:345-350
  • Phytomedicine.2019, 67:153159
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Arch Biochem Biophys.2020, 687:108363.
  • ...
  • 生物活性
    Description: Bruceantinol A is a natural product from Brucea javanica.
    In vitro:
    J Nat Prod. 2007 Oct;70(10):1654-7.
    Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica.[Pubmed: 17896817]
    Boiled extracts derived from 28 Indonesian medicinal plants were screened for their antibabesial activity against Babesia gibsoni in vitro.
    METHODS AND RESULTS:
    Of these extracts, the fruit of Brucea javanica was the most active in inhibiting parasite growth at a concentration of 10 microg/mL. Bioassay-guided fractionation of the fruit extract of Br. javanica led to the isolation of two new quassinoids, bruceantinol B and bruceine J, and the structures of these compounds were elucidated on the basis of their spectroscopic data and by chemical transformation to known compounds. In addition, the known quassinoids bruceines A-D, bruceantinol, and yadanziolide A were isolated.
    CONCLUSIONS:
    Antibabesial activities were also examined in vitro, and bruceine A and bruceantinol were shown to be more potent than diminazene aceturate, a drug (IC50 = 103 ng/mL) used clinically against B. gibsoni, with IC50 values of 4 and 12 ng/mL, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6875 mL 8.4375 mL 16.8751 mL 33.7501 mL 42.1877 mL
    5 mM 0.3375 mL 1.6875 mL 3.375 mL 6.75 mL 8.4375 mL
    10 mM 0.1688 mL 0.8438 mL 1.6875 mL 3.375 mL 4.2188 mL
    50 mM 0.0338 mL 0.1688 mL 0.3375 mL 0.675 mL 0.8438 mL
    100 mM 0.0169 mL 0.0844 mL 0.1688 mL 0.3375 mL 0.4219 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鸦胆苦内酯A; Yadanziolide A CFN96428 95258-14-3 C20H26O10 = 426.41 10mg QQ客服:1457312923
    鸦胆子素E; Bruceine E CFN89340 21586-90-3 C20H28O9 = 412.43 20mg QQ客服:2056216494
    鸦胆子苷I; Yadanzioside I CFN96421 99132-95-3 C29H38O16 = 642.60 5mg QQ客服:1457312923
    鸦胆子苷P; Yadanzioside P CFN96417 79439-84-2 C34H46O16 = 710.72 5mg QQ客服:215959384
    鸦胆子苷L ; Yadanzioside L CFN96419 99132-97-5 C34H46O17 = 726.72 5mg QQ客服:2159513211
    鸦胆子苷K; Yadanzioside K CFN96420 101559-98-2 C36H48O18 = 768.76 5mg QQ客服:1457312923
    13,18-二氢乐园树酮; 13,18-Dehydroglaucarubinone CFN92980 68703-94-6 C25H32O10 = 492.52 5mg QQ客服:3257982914
    (+)-乐园树酮; (+)-Glaucarubinone CFN92979 1259-86-5 C25H34O10 = 494.53 5mg QQ客服:2159513211
    鸦胆子素B; Bruceine B CFN89335 25514-29-8 C23H28O11 = 480.46 5mg QQ客服:215959384
    鸦胆子素C; Bruceine C CFN91974 25514-30-1 C28H36O12 = 564.58 5mg QQ客服:3257982914

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