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  • 博落回醇碱


    产品编号 CFN95373
    CAS编号 32906-88-0
    分子式 = 分子量 C22H21NO5 = 379.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Chelidonium majus
    产品名称 产品编号 CAS编号 包装 QQ客服
    博落回醇碱 CFN95373 32906-88-0 1mg QQ客服:215959384
    博落回醇碱 CFN95373 32906-88-0 5mg QQ客服:215959384
    博落回醇碱 CFN95373 32906-88-0 10mg QQ客服:215959384
    博落回醇碱 CFN95373 32906-88-0 20mg QQ客服:215959384
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
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  • 生物活性
    Description: Bocconoline strongly perturbs various cellular components of human olfactory neurosphere-derived (hONS) cell lines. Bocconoline exhibited good inhibitory activity in the leukaemia cell line HEL.Bocconoline has anticancer activity .
    In vitro:
    Bioorg Med Chem . 2020 Nov 1;28(21):115732.
    Chemical constituents from Macleaya cordata (Willd) R. Br. and their phenotypic functions against a Parkinson's disease patient-derived cell line[Pubmed: 33065438]
    Cytological profiling (CP) assay against a human olfactory neuroshpere-derived (hONS) cell line using a library of traditional Chinese medicinal plant extracts gave indications that the ethanolic extract of Macleaya cordata (Willd) R. Br. elicited strong perturbations to various cellular components. Further chemical investigation of this extract resulted in the isolation of two new benzo[c]phenanthridine alkaloids, (6R)-10-methoxybocconoline (1) and 6-(1-hydroxyethyl)-10-methoxy-5,6-dihydrochelerythrine (2). Their planar structures were elucidated by extensive 1D and 2D NMR studies, together with MS data. The absolute configuration for position C-6 of 1 and relative configurations for position C-6 and C-1' of 2 were assigned by density functional theory (DFT) calculations of ECD and NMR data, respectively. Also isolated were fourteen known metabolites, including ten alkaloids (3-12) and four coumaroyl-containing compounds (13-16). Cytological profiling of the isolates against Parkinson's Disease (PD) patient-derived olfactory cells revealed bocconoline (3) and 6-(1-hydroxyethyl)-5,6-dihydrochelerythrine (4) significantly perturbated the features of cellular organelles including early endosomes, mitochondria and autophagosomes. Given that hONS cells from PD patients model some functional aspects of the disease, the results suggested that these phenotypic profiles may have a role in the mechanisms underlying PD and signified the efficacy of CP in finding potential chemical tools to study the biological pathways in PD.
    Int J Mol Sci. 2013 Dec 2;14(12):23533-23544.
    Identification and quantification of the main active anticancer alkaloids from the root of Glaucium flavum[Pubmed: 24317429]
    Glaucium flavum is used in Algerian folk medicine to remove warts (benign tumors). Its local appellations are Cheqiq el-asfar and Qarn el-djedyane. We have recently reported the anti-tumoral activity of Glaucium flavum root alkaloid extract against human cancer cells, in vitro and in vivo. The principal identified alkaloid in the extract was protopine. This study aims to determine which component(s) of Glaucium flavum root extract might possess potent antitumor activity on human cancer cells. Quantitative estimation of Glaucium flavum alkaloids was realized by HPLC-DAD. Glaucium flavum effect on human normal and cancer cell viability was determined using WST-1 assay. Quantification of alkaloids in Glaucium flavum revealed that the dried root part contained 0.84% of protopine and 0.07% of bocconoline (w/w), while the dried aerial part contained only 0.08% of protopine, glaucine as the main alkaloid, and no bocconoline. In vitro evaluation of the growth inhibitory activity on breast cancer and normal cells demonstrated that purified protopine did not reproduce the full cytotoxic activity of the alkaloid root extract on cancer cell lines. On the other hand, bocconoline inhibited strongly the viability of cancer cells with an IC50 of 7.8 μM and only a low cytotoxic effect was observed against normal human cells. Our results showed for the first time that protopine is the major root alkaloid of Glaucium flavum. Finally, we are the first to demonstrate a specific anticancer effect of Glaucium flavum root extract against breast cancer cells, which can be attributed, at least in part, to bocconoline.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6357 mL 13.1787 mL 26.3574 mL 52.7148 mL 65.8935 mL
    5 mM 0.5271 mL 2.6357 mL 5.2715 mL 10.543 mL 13.1787 mL
    10 mM 0.2636 mL 1.3179 mL 2.6357 mL 5.2715 mL 6.5894 mL
    50 mM 0.0527 mL 0.2636 mL 0.5271 mL 1.0543 mL 1.3179 mL
    100 mM 0.0264 mL 0.1318 mL 0.2636 mL 0.5271 mL 0.6589 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    bis[6-(5,6-dihydrochelerythrinyl)]amine; bis[6-(5,6-dihydrochelerythrinyl)]amine CFN91015 165393-48-6 C42H37N3O8 = 711.76 5mg QQ客服:2159513211
    乙酰紫堇灵; Acetylcorynoline CFN99749 18797-80-3 C23H23NO6 = 409.43 20mg QQ客服:3257982914
    白屈菜碱; Chelidonine CFN90319 476-32-4 C20H19NO5 = 353.37 20mg QQ客服:1413575084
    二氢白屈菜红碱; Dihydrochelerythrine CFN90127 6880-91-7 C21H19NO4 = 349.38 20mg QQ客服:3257982914
    去甲白屈菜红碱; Norchelerythrine CFN92737 6900-99-8 C20H15NO4 = 333.3 5mg QQ客服:2932563308
    氧基白屈菜季铵碱; Oxychelerythrine CFN97999 28342-33-8 C21H17NO5 = 363.4 5mg QQ客服:3257982914
    德卡林碱; Decarine CFN98909 54354-62-0 C19H13NO4 = 319.3 5mg QQ客服:1413575084
    氯化两面针碱; Nitidine chloride CFN98109 13063-04-2 C21H18ClNO4 = 383.83 20mg QQ客服:2159513211
    血根碱; Sanguinarine CFN98259 2447-54-3 C20H14NO4 = 332.3 20mg QQ客服:3257982914
    二氢血根碱; Dihydrosanguinarine CFN92810 3606-45-9 C20H15NO4 = 333.1 20mg QQ客服:1148253675





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