Alpinone 3-acetate

	产品编号	CFN89493
	CAS编号	139906-49-3
	分子式 = 分子量	C₁₈H₁₆O₆ = 328.31
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The seeds of Alpinia japonica.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Alpinone 3-acetate	CFN89493	139906-49-3	1mg	QQ客服：3257982914
Alpinone 3-acetate	CFN89493	139906-49-3	5mg	QQ客服：3257982914
Alpinone 3-acetate	CFN89493	139906-49-3	10mg	QQ客服：3257982914
Alpinone 3-acetate	CFN89493	139906-49-3	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Dicle (Turkey)

Stanford University (USA)

MTT Agrifood Research Finland (Finland)

Indian Institute of Science (India)

University of Hertfordshire (United Kingdom)

Rio de Janeiro State University (Brazil)

University of Canterbury (New Zealand)

Instytut Nawozów Sztucznych w Pu?awach (Poland)

University of Maryland School of Medicine (USA)

University of Sao Paulo (Brazil)

University of Cincinnati (USA)

University of Pretoria (South Africa)

Utah State University (USA)

University of Bonn (Germany)

More...

Description:

Alpinone 3-acetate has anti-inflammatory activity, it can inhibit 12-O-tetradecanoyiphorbol 13-acetate-induced inflammation in a mouse model of ear edema.

Targets:

Immunology & Inflammation related

In vivo:

J Nat Med. 2016 Jul;70(3):653-60.

Anti-inflammatory effects of alpinone 3-acetate from Alpinia japonica seeds.[Pubmed: 27137785]

We aimed to investigate the bioactive components of Alpinia japonica as anti-inflammatory compounds using searches of the Alpinia genus, and subsequently demonstrated that Alpinone 3-acetate markedly inhibits 12-O-tetradecanoyiphorbol 13-acetate-induced inflammation in a mouse model of ear edema.
METHODS AND RESULTS:
To assess other bioactivities of Alpinone 3-acetate, we performed translatome analyses and compared them with those of hydrocortisone. Polysome-associated mRNAs were prepared from Alpinone 3-acetate- or hydrocortisone-treated and control cells from 12-O-tetradecanoyiphorbol 13-acetate-induced THP-1-derived macrophages cultured in the presence of Escherichia coli O-111 lipopolysaccharide. Subsequent microarray analysis revealed that Alpinone 3-acetate and hydrocortisone upregulated and downregulated the same 155 and 41 genes, respectively. Moreover, direct comparisons of translationally regulated genes indicated 5 and 10 gene probes that were upregulated and downregulated by Alpinone 3-acetate and hydrocortisone, respectively.
CONCLUSIONS:
In conclusion, assays of 12-O-tetradecanoyiphorbol 13-acetate-induced inflammation ear edema in mice and polysome profiling of Alpinone 3-acetate bioactivities indicated similar medicinal possibilities to those of hydrocortisone.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
短叶松素; Pinobanksin	CFN98917	548-82-3	C₁₅H₁₂O₅ = 272.3	5mg	QQ客服：1413575084
3-O-乙酰短叶松素; 3-O-Acetylpinobanksin	CFN98845	52117-69-8	C₁₇H₁₄O₆ = 314.3	5mg	QQ客服：215959384
Pinobanksin 3-O-propanoate; Pinobanksin 3-O-propanoate	CFN89460	126394-70-5	C₁₈H₁₆O₆ = 328.31	5mg	QQ客服：2159513211
3,7-O-二乙酰基短叶松素; 3,7-O-Diacetylpinobanksin	CFN99051	103553-98-6	C₁₉H₁₆O₇ = 356.3	5mg	QQ客服：2056216494
Pinobanksin 5-methyl ether; Pinobanksin 5-methyl ether	CFN89500	119309-36-3	C₁₆H₁₄O₅ = 286.27	5mg	QQ客服：215959384
Alpinone 3-acetate; Alpinone 3-acetate	CFN89493	139906-49-3	C₁₈H₁₆O₆ = 328.31	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0459 mL	15.2295 mL	30.459 mL	60.918 mL	76.1475 mL
5 mM	0.6092 mL	3.0459 mL	6.0918 mL	12.1836 mL	15.2295 mL
10 mM	0.3046 mL	1.523 mL	3.0459 mL	6.0918 mL	7.6148 mL
50 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.2184 mL	1.523 mL
100 mM	0.0305 mL	0.1523 mL	0.3046 mL	0.6092 mL	0.7615 mL