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  • 5,6,7,3',4'-五甲氧基二氢黄酮

    5,6,7,3',4'-Pentamethoxyflavanone

    5,6,7,3',4'-五甲氧基二氢黄酮
    产品编号 CFN95394
    CAS编号 104193-93-3
    分子式 = 分子量 C20H22O7 = 374.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Gardenia sootepensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5,6,7,3',4'-五甲氧基二氢黄酮 CFN95394 104193-93-3 1mg QQ客服:2159513211
    5,6,7,3',4'-五甲氧基二氢黄酮 CFN95394 104193-93-3 5mg QQ客服:2159513211
    5,6,7,3',4'-五甲氧基二氢黄酮 CFN95394 104193-93-3 10mg QQ客服:2159513211
    5,6,7,3',4'-五甲氧基二氢黄酮 CFN95394 104193-93-3 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Parma (Italy)
  • Nanjing University of Chinese Medicine (China)
  • Medical University of South Carolina (USA)
  • FORTH-IMBB (Greece)
  • Universite Libre de Bruxelles (Belgium)
  • University of Beira Interior (Portugal)
  • University of Leipzig (Germany)
  • University of Fribourg (Switzerland)
  • Universidad Miguel Hernández (Spain)
  • Lund University (Sweden)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Hertfordshire (United Kingdom)
  • Deutsches Krebsforschungszentrum (Germany)
  • Universit?t Basel (Switzerland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Nat Prod.2022, doi: 10.1021
  • Pharmacological Reports2020, 1-9
  • LWT2020, 124:109163
  • Clin Transl Med.2021, 11(5):e392.
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Appl. Sci.2020, 10(5),1713.
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • Phytochemistry Letters2017, 449-455
  • Applied Physics B2021, 127(92).
  • Molecules.2020, 25(17):3783.
  • J Food Sci.2021, 86(9):3810-3823.
  • Toxicol In Vitro.2019, 59:161-178
  • Metabolites.2020, 11(1):E11.
  • Nat Prod Commun.2017, 12(5):771-778
  • Toxicol Mech Methods.2021, 1-12.
  • Antiviral Res.2021, 193:105142.
  • Br J Pharmacol.2018, 175(6):902-923
  • iScience.2020, 23(2):100849.
  • Ind Crops Prod.2015, 67:185-191
  • J Med Food.2016, 19(12):1155-1165
  • J Sci Food Agric.2022, 102(4):1628-1639
  • Academic J of Second Military Medical University2018, 39(11)
  • Exp Parasitol.2018, 194:67-78
  • ...
  • 生物活性
    Description: 5,6,7,3',4'-pentamethoxyflavanone exhibited anti-proliferative activities. 5,6,7,3',4'-Pentamethoxyflavanone inhibit PCSK9 mRNA expression with IC50 values of 21.4. 5,6,7,3',4'-pentamethoxyflavanone could also significantly inhibit NO production.
    In vitro:
    Bioorg Chem . 2020 Jun;99:103869.
    A stilbene dimer and flavonoids from the aerial parts of Chromolaena odorata with proprotein convertase subtilisin/kexin type 9 expression inhibitory activity[Pubmed: 32335358]
    Investigation of components of the chloroform-soluble and ethyl acetate-soluble extracts of the aerial parts of Chromolaena odorata L. selected by PCSK9 mRNA expression monitoring assay in HepG2 cells led to the isolation of a new stilbene dimer, (+)-8b-epi-ampelopsin A (1), and 30 known compounds (2-31). The structures of the isolates were established by interpretation of NMR spectroscopic data and the stereochemistry of the new stilbene (1) was proposed based on ECD and NMR calculations. Among the isolates, 1, 5,6,7,4'-tetramethoxyflavanone (6), 5,6,7,3',4'-pentamethoxyflavanone (7), acacetin (18), and uridine (21) were found to inhibit PCSK9 mRNA expression with IC50 values of 20.6, 21.4, 31.7, 15.0, and 13.7 μM, respectively. Furthermore, the most abundant isolate among the selected compounds, 6, suppressed PCSK9 and low-density lipoprotein receptor protein expression in addition to downregulating the mRNA expression of HNF-1α.
    Nat Prod Res . 2021 Aug 5;1-6.
    Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives[Pubmed: 34353180]
    A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4'-hydroxyflavone (1a), 5,6,7,3',4' -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3',4'-methyl enedioxy flavone (1c), 5,6,7,3'-tetramethoxy-4,5'-methylenedioxyflavone (1e), 5,6,7, 3',4',5'-hextamethoxyflavone (1 g), 5-hydroxy-3,4,2',3',4'-pentamethoxy chal-cone (2 b), 5,4'-dihydroxy-6,7-dimethoxy flavone (cirsimaritin, 3a) and 5-hydroxy-6,7,3', 4'-tetramethoxyflavone (5-demethylsinensetin, 3 b), 3,5,6,7,3',4'-hexamethoxyflavone (3-methoxysinensetin, 4) and 5'-hydroxy-3,6,7,3',4'-pentamethoxyflavone (5) were synthesized. Their anti-proliferative activity in vitro was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2 and SUN-5) by the CTG assay. The results showed that most of the synthetic compounds exhibited moderate to high anti-proliferative activities. In particular, compound 3c possess IC50 (5.30 μM) values below 10 μM against Aspc-1 cells and are worthy of further investigation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6709 mL 13.3547 mL 26.7094 mL 53.4188 mL 66.7735 mL
    5 mM 0.5342 mL 2.6709 mL 5.3419 mL 10.6838 mL 13.3547 mL
    10 mM 0.2671 mL 1.3355 mL 2.6709 mL 5.3419 mL 6.6774 mL
    50 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.0684 mL 1.3355 mL
    100 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.5342 mL 0.6677 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异奥卡宁; Isookanin CFN90850 1036-49-3 C15H12O6 = 288.3 10mg QQ客服:2159513211
    黄诺马苷; Flavanomarein CFN91006 577-38-8 C21H22O11 = 450.4 5mg QQ客服:3257982914
    黄苏木素; Plathymenin CFN96496 492-12-6 C15H12O6 = 288.25 5mg QQ客服:2159513211
    圣草酚; Eriodictyol CFN99719 552-58-9 C15H12O6 = 288.25 20mg QQ客服:215959384
    7-O-甲基圣草酚; 7-O-Methyleriodictyol CFN98833 51857-11-5 C16H14O6 = 302.3 5mg QQ客服:2159513211
    高圣草素; Homoeriodictyol CFN96489 446-71-9 C16H14O6 = 302.28 5mg QQ客服:2159513211
    槲寄生新甙III; Viscumneoside III CFN89421 118985-27-6 C27H32O15 = 596.53 10mg QQ客服:1413575084
    圣草酚 7,3'-二甲醚; Eriodictyol 7,3'-dimethyl ether CFN89533 54352-60-2 C17H16O6 = 316.30 5mg QQ客服:3257982914
    橙皮素; Hesperetin CFN98842 520-33-2 C16H14O6 = 302.3 20mg QQ客服:1148253675
    橙皮素-7-甲醚; Hesperetin-7-methyl ether CFN90876 N/A C17H16O6 = 316.3 10mg QQ客服:215959384

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