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  • 3-氧代-12-烯-28-齐墩果酸

    3-oxo-Olean-12-en-28-oic acid

    3-氧代-12-烯-28-齐墩果酸
    产品编号 CFN92194
    CAS编号 17990-42-0
    分子式 = 分子量 C30H46O3 = 454.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The leaves of Eriobotrya japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-氧代-12-烯-28-齐墩果酸 CFN92194 17990-42-0 10mg QQ客服:3257982914
    3-氧代-12-烯-28-齐墩果酸 CFN92194 17990-42-0 20mg QQ客服:3257982914
    3-氧代-12-烯-28-齐墩果酸 CFN92194 17990-42-0 50mg QQ客服:3257982914
    3-氧代-12-烯-28-齐墩果酸 CFN92194 17990-42-0 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University (Australia)
  • Kyung Hee University (Korea)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • John Innes Centre (United Kingdom)
  • University of Zurich (Switzerland)
  • Nanjing University of Chinese Medicine (China)
  • Universitas Airlangga (Indonesia)
  • Monash University Malaysia (Malaysia)
  • Worcester Polytechnic Institute (USA)
  • Universiti Malaysia Pahang (Malaysia)
  • University of Minnesota (USA)
  • Lund University (Sweden)
  • Universidade da Beira Interior (Germany)
  • Almansora University (Egypt)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Korean J Pain.2021, 34(4):405-416.
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • Molecules.2020, 25(3):734
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Academic J of Second Military Medical University2018, 39(11)
  • Phytochemistry Letters2021, 43:80-87.
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • J Plant Biotechnol.2023, 50:070-075.
  • Phytomedicine.2019, 56:48-56
  • ACS Pharmacol. Transl. Sci.2022, 5,7,479-490
  • J Agric Food Chem.2020, 68(51):15164-15175
  • Anat Rec (Hoboken).2021, 304(2):323-332.
  • Chung Shan Medical University2020, US20200323790A1
  • Analytical sci. & Tech2016, 186-193
  • Phytomedicine.2021, 2(82):153452
  • J.Food Processing & Preservation2022, jfpp.16666
  • Onco Targets Ther.2017, 10:3467-3474
  • Front Microbiol.2021, 12:736780.
  • PLoS One.2017, 12(3):e0173585
  • Anal Sci.2019, 35(12):1317-1325
  • Biosci Rep.2020, 40(8):BSR20201219.
  • ...
  • 生物活性
    Description: 3-oxo-Olean-12-en-28-oic acid and kulinone have cytotoxic effects, with IC50 values of 5.6-21.2 μg/mL.
    In vitro:
    Planta Med., 2011, 77(9):922-8.
    Cytotoxic triterpenoids and steroids from the bark of Melia azedarach.[Pubmed: 21243584]
    Two new triterpenoids (1, 2) and two new steroids (3, 4) along with twelve related known compounds (5-16) were isolated from the bark of Melia azedarach.
    METHODS AND RESULTS:
    The new structures were elucidated by means of spectroscopic methods and molecular modeling studies and found to be 21,24-cycloeupha-7-ene-3 β,16 β,21 α,25-tetrol (1), 3 β-acetoxy-12 β-hydroxy-eupha-7,24-dien-21,16 β-olide (2), 29-hydroperoxy-stigmasta-7,24(28) E-dien-3 β-ol (3), and 24 ξ-hydroperoxy-24-vinyl-lathosterol (4). All isolated compounds were tested for their cytotoxic activity against three human cancer cell lines (A549, H460, HGC27) using the CellTiter Glo™ luminescent cell viability assay.
    CONCLUSIONS:
    Among them, compounds 2- 4, 24 ξ-hydroperoxy-24-vinyl-cholesterol (6), kulinone (7), meliastatin 3 ( 8), 3-oxo-Olean-12-en-28-oic acid (10), and (22 E,24 S)-5 α,8 α-epidioxy-24-methyl-cholesta-6,22-dien-3 β-ol (12) were found to have cytotoxic effects, with IC₅₀ values of 5.6-21.2 μg/mL.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1993 mL 10.9963 mL 21.9925 mL 43.985 mL 54.9813 mL
    5 mM 0.4399 mL 2.1993 mL 4.3985 mL 8.797 mL 10.9963 mL
    10 mM 0.2199 mL 1.0996 mL 2.1993 mL 4.3985 mL 5.4981 mL
    50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0996 mL
    100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-O-咖啡酰基齐墩果酸; 3-O-Caffeoyloleanolic acid CFN96050 97534-10-6 C39H54O6 = 618.9 5mg QQ客服:215959384
    3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid; 3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid CFN95710 469895-08-7 C32H50O5 = 514.8 5mg QQ客服:2056216494
    3-氧代-12-烯-28-齐墩果酸; 3-oxo-Olean-12-en-28-oic acid CFN92194 17990-42-0 C30H46O3 = 454.7 20mg QQ客服:215959384
    3-Keto-齐墩果酸-28-甲酯; 3-Oxo-olean-12-en-28-oic acid methyl ester CFN91814 1721-58-0 C31H48O3 = 468.7 5mg QQ客服:3257982914
    Virgatic acid; Virgatic acid CFN96451 14356-51-5 C30H46O4 = 470.70 5mg QQ客服:1457312923
    刺囊酸; Echinocystic acid CFN98812 510-30-5 C30H48O4 = 472.7 20mg QQ客服:215959384
    3alpha-木通萜酸; 3alpha-Akebonoic acid CFN99067 104777-61-9 C29H44O3 = 440.7 5mg QQ客服:1457312923
    Sebiferenic acid; Sebiferenic acid CFN97523 94390-09-7 C30H48O4 = 472.7 5mg QQ客服:3257982914
    3,4-开环-齐墩果-12-烯-4-醇-3,28-二酸; 3,4-seco-Olean-12-en-4-ol-3,28-dioic acid CFN96849 182249-69-0 C30H48O5 = 488.70 5mg QQ客服:1457312923
    3-氧代-24-去甲齐墩果-12-烯-28-酸 ; Hedragonic acid CFN96602 466-02-4 C29H44O3 = 440.66 5mg QQ客服:3257982914

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