2-乙酰苯甲酸

2-Acetylbenzoic acid

	产品编号	CFN98978
	CAS编号	577-56-0
	分子式 = 分子量	C₉H₈O₃ = 164.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The herbs of Impatiens balsamina.
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产品名称	产品编号	CAS编号	包装	QQ客服
2-乙酰苯甲酸	CFN98978	577-56-0	10mg	QQ客服：215959384
2-乙酰苯甲酸	CFN98978	577-56-0	20mg	QQ客服：215959384
2-乙酰苯甲酸	CFN98978	577-56-0	50mg	QQ客服：215959384
2-乙酰苯甲酸	CFN98978	577-56-0	100mg	QQ客服：215959384

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Description:

2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potencies of these agents were comparable in inhibiting prostacyclin (PGI2) synthesis.

Targets:

PGE

In vitro:

Prostaglandins Leukot Med. 1982 Jul;9(1):9-23.

Structure-activity studies of aspirin and related compounds on platelet aggregation, arachidonic acid metabolism in platelets and artery, and arterial prostacyclin activity.[Pubmed: 6813878 ]

METHODS AND RESULTS:
A series of benzoic acid derivatives was tested for specificity of action on human platelet function and platelet prostaglandin (PG) synthesis versus prostacyclin (PGI2) production by rat and rabbit aorta rings. None of the agents tested was more specific for one system than the other. ASA was more potent than 2-propionyloxybenzoic acid (2-PBA) in inhibiting platelet function and platelet PG synthesis although the potencies of these agents were comparable in inhibiting PGI2 synthesis. 3-Propionyloxybenzoic acid (3-PBA) caused increased activity in both systems while 2-acetylbenzoic acid (ABA) had only minor effects. A cyclical derivative, 3-methylphthalide (3-MP), inhibited both platelet function and PGI2 synthesis although it did not inhibit cyclo-oxygenase activity, suggesting a novel mechanism of action.
CONCLUSIONS:
Thus only minor changes in the ASA molecule could be effected without significant changes in pharmacological activity. The investigation of novel agents such as 3-MP may lead to a better understanding of arachidonate metabolism in different tissues and possibly to the development of more tissue-specific drugs.

In vivo:

Agents Actions. 1981 May;11(3):281-6.

Relationship of inhibition of prostaglandin synthesis in platelets to anti-aggregatory and anti-inflammatory activity of some benzoic acid derivatives.[Pubmed: 7257955]

The relationships between inhibition of platelet prostaglandin (PG) synthesis and aggregation, and suppression inflammation were investigated with a number of benzoic acid (aspirin-like) chemicals.
METHODS AND RESULTS:
The compounds studied were 2-acetylbenzoic acid (ABA), 3-methylphthalide (3-MP), 3-propionyloxybenzoic acid (3-PBA) and 2-propionyloxybenzoic acid (2-PBA). At 0.5--0.6 mM, 3-MP inhibited the second phase of ADP-induced aggregation in human platelets, and reduced collagen-induced aggregation by 50%. Previous studies have shown 2-PBA to inhibit aggregation at similar concentrations. In contrast, ABA required 10 times higher concentrations, and low concentrations actually potentiated aggregation. Inhibition of PG synthesis from 14C-arachidonic acid (AA) by human platelets was shown for 2-PBA, but not to 3-BPA, or ABA. At high concentration (1 mM), 3-MP showed modest inhibitory activity. Significant inhibition of AA aggregation was produced by ASA (83%), 2-PBA (76%) and 3-MP (69%), an order reflecting their inhibition of PG synthesis, where ABA and 3-PBA did not inhibit AA aggregation. Carrageenin-induced edema of the rat paw was suppressed by 3-MP, ABA and 2-PBA; all being roughly equipotent with aspirin. In contrast, 3-PBA did not suppress edema. Following oral administration of the drugs to rats, PG synthesis from labeled AA by rat platelets showed similar profiles to effects of the drugs on PG synthesis in human platelets.
CONCLUSIONS:
This suggests that biotransformation or species differences are not explanations for the observed differences in activity in the various test systems. The results indicate that, in a related series of chemicals there is not a good correlation between ability to inhibit platelet PG synthesis, anti-aggregatory activity and anti-inflammatory activity. Multiple mechanisms of action, differing sensitivities of various tissue PG synthetases, or unidentified factors could be involved.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
升麻酸F; Cimicifugic acid F	CFN70314	220618-91-7	C₂₁H₂₀O₁₀ = 432.4	5mg	QQ客服：3257982914
升麻酸B; Cimicifugic acid B	CFN70303	205114-66-5	C₂₁H₂₀O₁₁ = 448.4	5mg	QQ客服：2056216494
巴利森苷E; Parishin E	CFN93115	952068-57-4	C₁₉H₂₄O₁₃ = 460.4	20mg	QQ客服：1413575084
巴利森苷G; Parishin G	CFN95324	952283-93-1	C₁₉H₂₄O₁₃ = 460.4	10mg	QQ客服：215959384
巴利森苷B; Parishin B	CFN93113	174972-79-3	C₃₂H₄₀O₁₉ = 728.7	20mg	QQ客服：2056216494
巴利森苷C; Parishin C	CFN93114	174972-80-6	C₃₂H₄₀O₁₉ = 728.7	20mg	QQ客服：1457312923
巴利森苷A; Parishin A	CFN93112	62499-28-9	C₄₅H₅₆O₂₅ = 996.9	20mg	QQ客服：1413575084
1,4-二[4-(葡萄糖氧)苄基]-2-异丁基苹果酸酯; Militarine	CFN90409	58139-23-4	C₃₄H₄₆O₁₇ = 726.73	20mg	QQ客服：215959384
Dactylorhin A; Dactylorhin A	CFN95032	256459-34-4	C₄₀H₅₆O₂₂ = 888.9	20mg	QQ客服：2159513211
Gymnoside III; Gymnoside III	CFN95033	899430-03-6	C₄₂H₅₈O₂₃ = 930.9	10mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.0901 mL	30.4507 mL	60.9013 mL	121.8027 mL	152.2533 mL
5 mM	1.218 mL	6.0901 mL	12.1803 mL	24.3605 mL	30.4507 mL
10 mM	0.609 mL	3.0451 mL	6.0901 mL	12.1803 mL	15.2253 mL
50 mM	0.1218 mL	0.609 mL	1.218 mL	2.4361 mL	3.0451 mL
100 mM	0.0609 mL	0.3045 mL	0.609 mL	1.218 mL	1.5225 mL

2-乙酰苯甲酸

2-Acetylbenzoic acid

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