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  • 10-姜烯酚

    10-Shogaol

    10-姜烯酚
    产品编号 CFN92300
    CAS编号 36752-54-2
    分子式 = 分子量 C21H32O3 = 332.5
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Phenols
    植物来源 The rhizomes of Zingber officinale Rosc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    10-姜烯酚 CFN92300 36752-54-2 10mg QQ客服:2159513211
    10-姜烯酚 CFN92300 36752-54-2 20mg QQ客服:2159513211
    10-姜烯酚 CFN92300 36752-54-2 50mg QQ客服:2159513211
    10-姜烯酚 CFN92300 36752-54-2 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Weizmann Institute of Science (Israel)
  • Universit?t Basel (Switzerland)
  • Universidad de La Salle (Mexico)
  • University of Zurich (Switzerland)
  • Agricultural Research Organization (ARO) (Israel)
  • Texas A&M University (USA)
  • Worcester Polytechnic Institute (USA)
  • Universiti Putra Malaysia(UPM) (Malaysia)
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  • Medizinische Universit?t Wien (Austria)
  • Monash University Malaysia (Malaysia)
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  • Helmholtz Zentrum München (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Genes Genomics.2020, 10.1007
  • Chemistry of Natural Compounds2020, 56,423-426
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • Int J Mol Sci.2019, 20(14):E3538
  • Front Immunol. 2020, 11:62.
  • Front Pharmacol.2021, 12:744624.
  • BMC Plant Biol.2022, 22(1):128.
  • Viruses.2021, 13(11):2118.
  • Molecules.2020, 25(23):5556.
  • J Adv Res.2019, 17:85-94
  • Phytomedicine.2020, 79, 153351
  • Int J Mol Sci.2022, 23(11):6172.
  • Int J Mol Sci.2022, 23(24):16000.
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Drug Des Devel Ther.2020, 14:61-71
  • Appl. Sci.2020, 10(23), 8729
  • Adaptive Medicine 2020, 12(1): 4-10
  • Br J Pharmacol.2016, 173(2):396-410
  • Molecules2022, 27(12):3903.
  • J Nat Med.2017, 71(2):457-462
  • Phytomedicine.2023, 117:154929.
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • J Ethnopharmacol.2022, 291:115159.
  • ...
  • 生物活性
    Description: 10-Shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.8- and 10-Shogaol have similar metabolic profiles to [6]-shogaol and exhibit similar toxicity toward human colon cancer cells.
    Targets: TGF-β/Smad | PDGFR | VEGFR
    In vitro:
    Int J Mol Sci. 2012;13(2):1762-77.
    10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer.[Pubmed: 22408422]

    METHODS AND RESULTS:
    In this work, one of Zingiber officinale components, 10-Shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-Shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group.
    CONCLUSIONS:
    Thus, this study substantiates the target compound, 10-Shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
    J Agric Food Chem. 2014 May 21;62(20):4632-42.
    Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells.[Pubmed: 24786146]
    Shogaols, the major constituents of thermally processed ginger, have been proven to be highly effective anticancer agents.
    METHODS AND RESULTS:
    Our group has identified cysteine-conjugated shogaols (M2, M2', and M2″) as the major metabolites of [6]-, [8]-, and 10-Shogaol in human and found that M2 is a carrier of its parent molecule [6]-shogaol in cancer cells and in mice, while being less toxic to normal colon fibroblast cells. The objectives of this study are to determine whether M2' and M2″ behave in a similar manner to M2, in both metabolism and efficacy as anticancer agents, and to further explore the biological pro-apoptotic mechanisms of the cysteine-conjugated shogaols against human colon cancer cells HCT-116 and HT-29.
    CONCLUSIONS:
    Our results show that [8]- and 10-Shogaol have similar metabolic profiles to [6]-shogaol and exhibit similar toxicity toward human colon cancer cells. A brief screen of the markers attenuated by the proapoptotic activity of M2 revealed similar results for [8]- and 10-Shogaol and their respective cysteine-conjugated metabolites M2' and M2″. This study highlights the cysteine-conjugated metabolites of shogaols as novel dietary colon cancer preventive agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0075 mL 15.0376 mL 30.0752 mL 60.1504 mL 75.188 mL
    5 mM 0.6015 mL 3.0075 mL 6.015 mL 12.0301 mL 15.0376 mL
    10 mM 0.3008 mL 1.5038 mL 3.0075 mL 6.015 mL 7.5188 mL
    50 mM 0.0602 mL 0.3008 mL 0.6015 mL 1.203 mL 1.5038 mL
    100 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6015 mL 0.7519 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1-脱氢-6-姜酮; 1-Dehydro-6-gingerdione CFN92298 76060-35-0 C17H22O4 = 290.4 10mg QQ客服:1413575084
    6-姜烯酚; 6-Shogaol CFN99531 555-66-8 C17H24O3 = 276.37 20mg QQ客服:2056216494
    二乙酰氧基-6-姜二醇; Diacetoxy-6-gingerdiol CFN92375 143615-75-2 C21H32O6 = 380.5 5mg QQ客服:1457312923
    二氢非洲豆蔻醇; Dihydroparadol CFN91532 143111-84-6 C17H28O3 = 280.4 10mg QQ客服:2159513211
    非洲豆蔻醇; Paradol CFN91045 27113-22-0 C17H26O3 = 278.39 10mg QQ客服:1457312923
    (E)-[6]-去氢非洲豆蔻醇; (E)-[6]-Dehydroparadol CFN91531 878006-06-5 C17H24O3 = 276.4 5mg QQ客服:2056216494
    8-姜烯酚; 8-Shogaol CFN92299 36700-45-5 C19H28O3 = 304.4 20mg QQ客服:1413575084
    10-姜烯酚; 10-Shogaol CFN92300 36752-54-2 C21H32O3 = 332.5 20mg QQ客服:2159513211
    6-姜酚; 6-Gingerol CFN99931 23513-14-6 C17H26O4 = 294.4 20mg QQ客服:1457312923
    8-姜酚; 8-Gingerol CFN99131 23513-08-8 C19H30O4 = 322.44 20mg QQ客服:2056216494

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